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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 19-14478566-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=14478566&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "19",
"pos": 14478566,
"ref": "C",
"alt": "T",
"effect": "splice_region_variant,synonymous_variant",
"transcript": "NM_005716.4",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.852G>A",
"hgvs_p": "p.Ala284Ala",
"transcript": "NM_005716.4",
"protein_id": "NP_005707.1",
"transcript_support_level": null,
"aa_start": 284,
"aa_end": null,
"aa_length": 333,
"cds_start": 852,
"cds_end": null,
"cds_length": 1002,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000393033.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_005716.4"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.852G>A",
"hgvs_p": "p.Ala284Ala",
"transcript": "ENST00000393033.9",
"protein_id": "ENSP00000376753.3",
"transcript_support_level": 1,
"aa_start": 284,
"aa_end": null,
"aa_length": 333,
"cds_start": 852,
"cds_end": null,
"cds_length": 1002,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_005716.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000393033.9"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.852G>A",
"hgvs_p": "p.Ala284Ala",
"transcript": "ENST00000345425.6",
"protein_id": "ENSP00000340698.1",
"transcript_support_level": 1,
"aa_start": 284,
"aa_end": null,
"aa_length": 333,
"cds_start": 852,
"cds_end": null,
"cds_length": 1002,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000345425.6"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.852G>A",
"hgvs_p": "p.Ala284Ala",
"transcript": "NM_202468.3",
"protein_id": "NP_974197.1",
"transcript_support_level": null,
"aa_start": 284,
"aa_end": null,
"aa_length": 333,
"cds_start": 852,
"cds_end": null,
"cds_length": 1002,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_202468.3"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.852G>A",
"hgvs_p": "p.Ala284Ala",
"transcript": "NM_202470.3",
"protein_id": "NP_974199.1",
"transcript_support_level": null,
"aa_start": 284,
"aa_end": null,
"aa_length": 333,
"cds_start": 852,
"cds_end": null,
"cds_length": 1002,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_202470.3"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.852G>A",
"hgvs_p": "p.Ala284Ala",
"transcript": "ENST00000586027.5",
"protein_id": "ENSP00000466747.1",
"transcript_support_level": 2,
"aa_start": 284,
"aa_end": null,
"aa_length": 333,
"cds_start": 852,
"cds_end": null,
"cds_length": 1002,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000586027.5"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.852G>A",
"hgvs_p": "p.Ala284Ala",
"transcript": "ENST00000885918.1",
"protein_id": "ENSP00000555977.1",
"transcript_support_level": null,
"aa_start": 284,
"aa_end": null,
"aa_length": 333,
"cds_start": 852,
"cds_end": null,
"cds_length": 1002,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885918.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.852G>A",
"hgvs_p": "p.Ala284Ala",
"transcript": "ENST00000885920.1",
"protein_id": "ENSP00000555979.1",
"transcript_support_level": null,
"aa_start": 284,
"aa_end": null,
"aa_length": 333,
"cds_start": 852,
"cds_end": null,
"cds_length": 1002,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885920.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.852G>A",
"hgvs_p": "p.Ala284Ala",
"transcript": "ENST00000885921.1",
"protein_id": "ENSP00000555980.1",
"transcript_support_level": null,
"aa_start": 284,
"aa_end": null,
"aa_length": 333,
"cds_start": 852,
"cds_end": null,
"cds_length": 1002,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885921.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.852G>A",
"hgvs_p": "p.Ala284Ala",
"transcript": "ENST00000885922.1",
"protein_id": "ENSP00000555981.1",
"transcript_support_level": null,
"aa_start": 284,
"aa_end": null,
"aa_length": 333,
"cds_start": 852,
"cds_end": null,
"cds_length": 1002,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885922.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.852G>A",
"hgvs_p": "p.Ala284Ala",
"transcript": "ENST00000931330.1",
"protein_id": "ENSP00000601389.1",
"transcript_support_level": null,
"aa_start": 284,
"aa_end": null,
"aa_length": 333,
"cds_start": 852,
"cds_end": null,
"cds_length": 1002,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931330.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.852G>A",
"hgvs_p": "p.Ala284Ala",
"transcript": "ENST00000931332.1",
"protein_id": "ENSP00000601391.1",
"transcript_support_level": null,
"aa_start": 284,
"aa_end": null,
"aa_length": 333,
"cds_start": 852,
"cds_end": null,
"cds_length": 1002,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931332.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.852G>A",
"hgvs_p": "p.Ala284Ala",
"transcript": "ENST00000952382.1",
"protein_id": "ENSP00000622441.1",
"transcript_support_level": null,
"aa_start": 284,
"aa_end": null,
"aa_length": 333,
"cds_start": 852,
"cds_end": null,
"cds_length": 1002,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000952382.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.852G>A",
"hgvs_p": "p.Ala284Ala",
"transcript": "ENST00000952383.1",
"protein_id": "ENSP00000622442.1",
"transcript_support_level": null,
"aa_start": 284,
"aa_end": null,
"aa_length": 333,
"cds_start": 852,
"cds_end": null,
"cds_length": 1002,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000952383.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.852G>A",
"hgvs_p": "p.Ala284Ala",
"transcript": "ENST00000952385.1",
"protein_id": "ENSP00000622444.1",
"transcript_support_level": null,
"aa_start": 284,
"aa_end": null,
"aa_length": 333,
"cds_start": 852,
"cds_end": null,
"cds_length": 1002,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000952385.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.852G>A",
"hgvs_p": "p.Ala284Ala",
"transcript": "ENST00000952386.1",
"protein_id": "ENSP00000622445.1",
"transcript_support_level": null,
"aa_start": 284,
"aa_end": null,
"aa_length": 333,
"cds_start": 852,
"cds_end": null,
"cds_length": 1002,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000952386.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.843G>A",
"hgvs_p": "p.Ala281Ala",
"transcript": "ENST00000885919.1",
"protein_id": "ENSP00000555978.1",
"transcript_support_level": null,
"aa_start": 281,
"aa_end": null,
"aa_length": 330,
"cds_start": 843,
"cds_end": null,
"cds_length": 993,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000885919.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.831G>A",
"hgvs_p": "p.Ala277Ala",
"transcript": "ENST00000931331.1",
"protein_id": "ENSP00000601390.1",
"transcript_support_level": null,
"aa_start": 277,
"aa_end": null,
"aa_length": 326,
"cds_start": 831,
"cds_end": null,
"cds_length": 981,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931331.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.831G>A",
"hgvs_p": "p.Ala277Ala",
"transcript": "ENST00000952384.1",
"protein_id": "ENSP00000622443.1",
"transcript_support_level": null,
"aa_start": 277,
"aa_end": null,
"aa_length": 326,
"cds_start": 831,
"cds_end": null,
"cds_length": 981,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000952384.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.561G>A",
"hgvs_p": "p.Ala187Ala",
"transcript": "NM_202469.3",
"protein_id": "NP_974198.1",
"transcript_support_level": null,
"aa_start": 187,
"aa_end": null,
"aa_length": 236,
"cds_start": 561,
"cds_end": null,
"cds_length": 711,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_202469.3"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GIPC1",
"gene_hgnc_id": 1226,
"hgvs_c": "c.561G>A",
"hgvs_p": "p.Ala187Ala",
"transcript": "NM_202494.3",
"protein_id": "NP_974223.1",
"transcript_support_level": null,
"aa_start": 187,
"aa_end": null,
"aa_length": 236,
"cds_start": 561,
"cds_end": null,
"cds_length": 711,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_202494.3"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
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{
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}
],
"message": null
}