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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 19-14565755-TCC-AGT (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=14565755&ref=TCC&alt=AGT&genome=hg38&allGenes=true"API Response
json
{
"message": null,
"variants": [
{
"acmg_by_gene": [
{
"benign_score": 0,
"criteria": [],
"effects": [
"synonymous_variant"
],
"gene_symbol": "TECR",
"hgnc_id": 4551,
"hgvs_c": "c.856_858delTCCinsAGT",
"hgvs_p": "p.287",
"inheritance_mode": "AR",
"pathogenic_score": 0,
"score": 0,
"transcript": "NM_001321170.1",
"verdict": "Uncertain_significance"
}
],
"acmg_classification": "Uncertain_significance",
"acmg_criteria": "",
"acmg_score": 0,
"allele_count_reference_population": 0,
"alphamissense_prediction": null,
"alphamissense_score": null,
"alt": "AGT",
"apogee2_prediction": null,
"apogee2_score": null,
"bayesdelnoaf_prediction": null,
"bayesdelnoaf_score": null,
"chr": "19",
"clinvar_classification": "",
"clinvar_disease": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
"computational_prediction_selected": null,
"computational_score_selected": null,
"computational_source_selected": null,
"consequences": [
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 308,
"aa_ref": "S",
"aa_start": 271,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1139,
"cdna_start": 914,
"cds_end": null,
"cds_length": 927,
"cds_start": 811,
"consequences": [
"synonymous_variant"
],
"exon_count": 13,
"exon_rank": null,
"exon_rank_end": null,
"feature": "NM_138501.6",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.811_813delTCCinsAGT",
"hgvs_p": "p.272",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "ENST00000215567.10",
"protein_coding": true,
"protein_id": "NP_612510.1",
"strand": true,
"transcript": "NM_138501.6",
"transcript_support_level": null
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 308,
"aa_ref": "S",
"aa_start": 271,
"biotype": "protein_coding",
"canonical": true,
"cdna_end": null,
"cdna_length": 1139,
"cdna_start": 914,
"cds_end": null,
"cds_length": 927,
"cds_start": 811,
"consequences": [
"synonymous_variant"
],
"exon_count": 13,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000215567.10",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.811_813delTCCinsAGT",
"hgvs_p": "p.272",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": "NM_138501.6",
"protein_coding": true,
"protein_id": "ENSP00000215567.4",
"strand": true,
"transcript": "ENST00000215567.10",
"transcript_support_level": 1
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 346,
"aa_ref": "S",
"aa_start": 309,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1188,
"cdna_start": 965,
"cds_end": null,
"cds_length": 1041,
"cds_start": 925,
"consequences": [
"synonymous_variant"
],
"exon_count": 12,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000596073.6",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.925_927delTCCinsAGT",
"hgvs_p": "p.310",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000472697.2",
"strand": true,
"transcript": "ENST00000596073.6",
"transcript_support_level": 1
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 375,
"aa_ref": "S",
"aa_start": 338,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1333,
"cdna_start": 1109,
"cds_end": null,
"cds_length": 1128,
"cds_start": 1012,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000971295.1",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.1012_1014delTCCinsAGT",
"hgvs_p": "p.339",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000641354.1",
"strand": true,
"transcript": "ENST00000971295.1",
"transcript_support_level": null
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 351,
"aa_ref": "S",
"aa_start": 314,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1268,
"cdna_start": 1043,
"cds_end": null,
"cds_length": 1056,
"cds_start": 940,
"consequences": [
"synonymous_variant"
],
"exon_count": 13,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000882755.1",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.940_942delTCCinsAGT",
"hgvs_p": "p.315",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000552814.1",
"strand": true,
"transcript": "ENST00000882755.1",
"transcript_support_level": null
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 341,
"aa_ref": "S",
"aa_start": 304,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1238,
"cdna_start": 1013,
"cds_end": null,
"cds_length": 1026,
"cds_start": 910,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000882754.1",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.910_912delTCCinsAGT",
"hgvs_p": "p.305",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000552813.1",
"strand": true,
"transcript": "ENST00000882754.1",
"transcript_support_level": null
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 340,
"aa_ref": "S",
"aa_start": 303,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1205,
"cdna_start": 980,
"cds_end": null,
"cds_length": 1023,
"cds_start": 907,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000971296.1",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.907_909delTCCinsAGT",
"hgvs_p": "p.304",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000641355.1",
"strand": true,
"transcript": "ENST00000971296.1",
"transcript_support_level": null
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 323,
"aa_ref": "S",
"aa_start": 286,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1240,
"cdna_start": 1015,
"cds_end": null,
"cds_length": 972,
"cds_start": 856,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": null,
"exon_rank_end": null,
"feature": "NM_001321170.1",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.856_858delTCCinsAGT",
"hgvs_p": "p.287",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "NP_001308099.1",
"strand": true,
"transcript": "NM_001321170.1",
"transcript_support_level": null
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 318,
"aa_ref": "S",
"aa_start": 281,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1164,
"cdna_start": 940,
"cds_end": null,
"cds_length": 957,
"cds_start": 841,
"consequences": [
"synonymous_variant"
],
"exon_count": 13,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000971293.1",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.841_843delTCCinsAGT",
"hgvs_p": "p.282",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000641352.1",
"strand": true,
"transcript": "ENST00000971293.1",
"transcript_support_level": null
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 307,
"aa_ref": "S",
"aa_start": 270,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1138,
"cdna_start": 913,
"cds_end": null,
"cds_length": 924,
"cds_start": 808,
"consequences": [
"synonymous_variant"
],
"exon_count": 13,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000882753.1",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.808_810delTCCinsAGT",
"hgvs_p": "p.271",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000552812.1",
"strand": true,
"transcript": "ENST00000882753.1",
"transcript_support_level": null
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 306,
"aa_ref": "S",
"aa_start": 269,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1149,
"cdna_start": 924,
"cds_end": null,
"cds_length": 921,
"cds_start": 805,
"consequences": [
"synonymous_variant"
],
"exon_count": 13,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000882752.1",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.805_807delTCCinsAGT",
"hgvs_p": "p.270",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000552811.1",
"strand": true,
"transcript": "ENST00000882752.1",
"transcript_support_level": null
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 306,
"aa_ref": "S",
"aa_start": 269,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1174,
"cdna_start": 942,
"cds_end": null,
"cds_length": 921,
"cds_start": 805,
"consequences": [
"synonymous_variant"
],
"exon_count": 13,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000913609.1",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.805_807delTCCinsAGT",
"hgvs_p": "p.270",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000583668.1",
"strand": true,
"transcript": "ENST00000913609.1",
"transcript_support_level": null
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 299,
"aa_ref": "S",
"aa_start": 262,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1105,
"cdna_start": 882,
"cds_end": null,
"cds_length": 900,
"cds_start": 784,
"consequences": [
"synonymous_variant"
],
"exon_count": 13,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000971294.1",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.784_786delTCCinsAGT",
"hgvs_p": "p.263",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000641353.1",
"strand": true,
"transcript": "ENST00000971294.1",
"transcript_support_level": null
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 291,
"aa_ref": "S",
"aa_start": 254,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1083,
"cdna_start": 859,
"cds_end": null,
"cds_length": 876,
"cds_start": 760,
"consequences": [
"synonymous_variant"
],
"exon_count": 12,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000882756.1",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.760_762delTCCinsAGT",
"hgvs_p": "p.255",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000552815.1",
"strand": true,
"transcript": "ENST00000882756.1",
"transcript_support_level": null
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 279,
"aa_ref": "S",
"aa_start": 242,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1045,
"cdna_start": 823,
"cds_end": null,
"cds_length": 840,
"cds_start": 724,
"consequences": [
"synonymous_variant"
],
"exon_count": 12,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000882757.1",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.724_726delTCCinsAGT",
"hgvs_p": "p.243",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000552816.1",
"strand": true,
"transcript": "ENST00000882757.1",
"transcript_support_level": null
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 275,
"aa_ref": "S",
"aa_start": 238,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1009,
"cdna_start": 785,
"cds_end": null,
"cds_length": 828,
"cds_start": 712,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000882758.1",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.712_714delTCCinsAGT",
"hgvs_p": "p.239",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000552817.1",
"strand": true,
"transcript": "ENST00000882758.1",
"transcript_support_level": null
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 274,
"aa_ref": "S",
"aa_start": 237,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1051,
"cdna_start": 826,
"cds_end": null,
"cds_length": 825,
"cds_start": 709,
"consequences": [
"synonymous_variant"
],
"exon_count": 11,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000913612.1",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.709_711delTCCinsAGT",
"hgvs_p": "p.238",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000583671.1",
"strand": true,
"transcript": "ENST00000913612.1",
"transcript_support_level": null
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 269,
"aa_ref": "S",
"aa_start": 232,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1042,
"cdna_start": 809,
"cds_end": null,
"cds_length": 810,
"cds_start": 694,
"consequences": [
"synonymous_variant"
],
"exon_count": 12,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000913611.1",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.694_696delTCCinsAGT",
"hgvs_p": "p.233",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000583670.1",
"strand": true,
"transcript": "ENST00000913611.1",
"transcript_support_level": null
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 150,
"aa_ref": "S",
"aa_start": 113,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 559,
"cdna_start": 337,
"cds_end": null,
"cds_length": 453,
"cds_start": 337,
"consequences": [
"synonymous_variant"
],
"exon_count": 6,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000601187.1",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.337_339delTCCinsAGT",
"hgvs_p": "p.114",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000472957.1",
"strand": true,
"transcript": "ENST00000601187.1",
"transcript_support_level": 3
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 62,
"aa_ref": "S",
"aa_start": 25,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 430,
"cdna_start": 205,
"cds_end": null,
"cds_length": 189,
"cds_start": 73,
"consequences": [
"synonymous_variant"
],
"exon_count": 3,
"exon_rank": null,
"exon_rank_end": null,
"feature": "ENST00000913610.1",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.73_75delTCCinsAGT",
"hgvs_p": "p.26",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
"protein_coding": true,
"protein_id": "ENSP00000583669.1",
"strand": true,
"transcript": "ENST00000913610.1",
"transcript_support_level": null
},
{
"aa_alt": "S",
"aa_end": null,
"aa_length": 341,
"aa_ref": "S",
"aa_start": 304,
"biotype": "protein_coding",
"canonical": false,
"cdna_end": null,
"cdna_length": 1272,
"cdna_start": 1047,
"cds_end": null,
"cds_length": 1026,
"cds_start": 910,
"consequences": [
"synonymous_variant"
],
"exon_count": 14,
"exon_rank": null,
"exon_rank_end": null,
"feature": "XM_006722945.3",
"gene_hgnc_id": 4551,
"gene_symbol": "TECR",
"hgvs_c": "c.910_912delTCCinsAGT",
"hgvs_p": "p.305",
"intron_rank": null,
"intron_rank_end": null,
"mane_plus": null,
"mane_select": null,
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