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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 19-18137336-T-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=18137336&ref=T&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 5,
          "criteria": [
            "PM2",
            "BP4_Strong",
            "BP7"
          ],
          "effects": [
            "synonymous_variant"
          ],
          "gene_symbol": "MAST3",
          "hgnc_id": 19036,
          "hgvs_c": "c.2094T>A",
          "hgvs_p": "p.Ala698Ala",
          "inheritance_mode": "AD",
          "pathogenic_score": 2,
          "score": -3,
          "transcript": "NM_001393501.1",
          "verdict": "Likely_benign"
        }
      ],
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "PM2,BP4_Strong,BP7",
      "acmg_score": -3,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "A",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.77,
      "chr": "19",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": -0.7699999809265137,
      "computational_source_selected": "BayesDel_noAF",
      "consequences": [
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1347,
          "aa_ref": "A",
          "aa_start": 690,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6020,
          "cdna_start": 2085,
          "cds_end": null,
          "cds_length": 4044,
          "cds_start": 2070,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 28,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "NM_001393504.1",
          "gene_hgnc_id": 19036,
          "gene_symbol": "MAST3",
          "hgvs_c": "c.2070T>A",
          "hgvs_p": "p.Ala690Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000687212.1",
          "protein_coding": true,
          "protein_id": "NP_001380433.1",
          "strand": true,
          "transcript": "NM_001393504.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1347,
          "aa_ref": "A",
          "aa_start": 690,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 6020,
          "cdna_start": 2085,
          "cds_end": null,
          "cds_length": 4044,
          "cds_start": 2070,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 28,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "ENST00000687212.1",
          "gene_hgnc_id": 19036,
          "gene_symbol": "MAST3",
          "hgvs_c": "c.2070T>A",
          "hgvs_p": "p.Ala690Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_001393504.1",
          "protein_coding": true,
          "protein_id": "ENSP00000509890.1",
          "strand": true,
          "transcript": "ENST00000687212.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1309,
          "aa_ref": "A",
          "aa_start": 661,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5896,
          "cdna_start": 1983,
          "cds_end": null,
          "cds_length": 3930,
          "cds_start": 1983,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 27,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000262811.10",
          "gene_hgnc_id": 19036,
          "gene_symbol": "MAST3",
          "hgvs_c": "c.1983T>A",
          "hgvs_p": "p.Ala661Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000262811.4",
          "strand": true,
          "transcript": "ENST00000262811.10",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1355,
          "aa_ref": "A",
          "aa_start": 698,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6044,
          "cdna_start": 2109,
          "cds_end": null,
          "cds_length": 4068,
          "cds_start": 2094,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 29,
          "exon_rank": 20,
          "exon_rank_end": null,
          "feature": "NM_001393501.1",
          "gene_hgnc_id": 19036,
          "gene_symbol": "MAST3",
          "hgvs_c": "c.2094T>A",
          "hgvs_p": "p.Ala698Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001380430.1",
          "strand": true,
          "transcript": "NM_001393501.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1348,
          "aa_ref": "A",
          "aa_start": 691,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6023,
          "cdna_start": 2088,
          "cds_end": null,
          "cds_length": 4047,
          "cds_start": 2073,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 28,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "NM_001393502.1",
          "gene_hgnc_id": 19036,
          "gene_symbol": "MAST3",
          "hgvs_c": "c.2073T>A",
          "hgvs_p": "p.Ala691Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001380431.1",
          "strand": true,
          "transcript": "NM_001393502.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1347,
          "aa_ref": "A",
          "aa_start": 690,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6149,
          "cdna_start": 2214,
          "cds_end": null,
          "cds_length": 4044,
          "cds_start": 2070,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 28,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "NM_001393503.1",
          "gene_hgnc_id": 19036,
          "gene_symbol": "MAST3",
          "hgvs_c": "c.2070T>A",
          "hgvs_p": "p.Ala690Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001380432.1",
          "strand": true,
          "transcript": "NM_001393503.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1337,
          "aa_ref": "A",
          "aa_start": 689,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6119,
          "cdna_start": 2211,
          "cds_end": null,
          "cds_length": 4014,
          "cds_start": 2067,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 28,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "NM_001393505.1",
          "gene_hgnc_id": 19036,
          "gene_symbol": "MAST3",
          "hgvs_c": "c.2067T>A",
          "hgvs_p": "p.Ala689Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001380434.1",
          "strand": true,
          "transcript": "NM_001393505.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1331,
          "aa_ref": "A",
          "aa_start": 674,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6136,
          "cdna_start": 2201,
          "cds_end": null,
          "cds_length": 3996,
          "cds_start": 2022,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 27,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "NM_001393506.1",
          "gene_hgnc_id": 19036,
          "gene_symbol": "MAST3",
          "hgvs_c": "c.2022T>A",
          "hgvs_p": "p.Ala674Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001380435.1",
          "strand": true,
          "transcript": "NM_001393506.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1331,
          "aa_ref": "A",
          "aa_start": 683,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6101,
          "cdna_start": 2193,
          "cds_end": null,
          "cds_length": 3996,
          "cds_start": 2049,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 27,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "NM_001393507.1",
          "gene_hgnc_id": 19036,
          "gene_symbol": "MAST3",
          "hgvs_c": "c.2049T>A",
          "hgvs_p": "p.Ala683Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001380436.1",
          "strand": true,
          "transcript": "NM_001393507.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1331,
          "aa_ref": "A",
          "aa_start": 683,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6112,
          "cdna_start": 2199,
          "cds_end": null,
          "cds_length": 3996,
          "cds_start": 2049,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 27,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000697701.1",
          "gene_hgnc_id": 19036,
          "gene_symbol": "MAST3",
          "hgvs_c": "c.2049T>A",
          "hgvs_p": "p.Ala683Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000513408.1",
          "strand": true,
          "transcript": "ENST00000697701.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1326,
          "aa_ref": "A",
          "aa_start": 669,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5971,
          "cdna_start": 2034,
          "cds_end": null,
          "cds_length": 3981,
          "cds_start": 2007,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 27,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000893417.1",
          "gene_hgnc_id": 19036,
          "gene_symbol": "MAST3",
          "hgvs_c": "c.2007T>A",
          "hgvs_p": "p.Ala669Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000563476.1",
          "strand": true,
          "transcript": "ENST00000893417.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1325,
          "aa_ref": "A",
          "aa_start": 668,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5954,
          "cdna_start": 2019,
          "cds_end": null,
          "cds_length": 3978,
          "cds_start": 2004,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 28,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "NM_001393508.1",
          "gene_hgnc_id": 19036,
          "gene_symbol": "MAST3",
          "hgvs_c": "c.2004T>A",
          "hgvs_p": "p.Ala668Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001380437.1",
          "strand": true,
          "transcript": "NM_001393508.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1324,
          "aa_ref": "A",
          "aa_start": 667,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5951,
          "cdna_start": 2016,
          "cds_end": null,
          "cds_length": 3975,
          "cds_start": 2001,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 28,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "NM_001393509.1",
          "gene_hgnc_id": 19036,
          "gene_symbol": "MAST3",
          "hgvs_c": "c.2001T>A",
          "hgvs_p": "p.Ala667Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001380438.1",
          "strand": true,
          "transcript": "NM_001393509.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1324,
          "aa_ref": "A",
          "aa_start": 667,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6115,
          "cdna_start": 2180,
          "cds_end": null,
          "cds_length": 3975,
          "cds_start": 2001,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 26,
          "exon_rank": 17,
          "exon_rank_end": null,
          "feature": "NM_001393510.1",
          "gene_hgnc_id": 19036,
          "gene_symbol": "MAST3",
          "hgvs_c": "c.2001T>A",
          "hgvs_p": "p.Ala667Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001380439.1",
          "strand": true,
          "transcript": "NM_001393510.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1323,
          "aa_ref": "A",
          "aa_start": 666,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6112,
          "cdna_start": 2177,
          "cds_end": null,
          "cds_length": 3972,
          "cds_start": 1998,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 26,
          "exon_rank": 17,
          "exon_rank_end": null,
          "feature": "NM_001393511.1",
          "gene_hgnc_id": 19036,
          "gene_symbol": "MAST3",
          "hgvs_c": "c.1998T>A",
          "hgvs_p": "p.Ala666Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001380440.1",
          "strand": true,
          "transcript": "NM_001393511.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1323,
          "aa_ref": "A",
          "aa_start": 667,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5948,
          "cdna_start": 2016,
          "cds_end": null,
          "cds_length": 3972,
          "cds_start": 2001,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 28,
          "exon_rank": 19,
          "exon_rank_end": null,
          "feature": "NM_001393512.1",
          "gene_hgnc_id": 19036,
          "gene_symbol": "MAST3",
          "hgvs_c": "c.2001T>A",
          "hgvs_p": "p.Ala667Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001380441.1",
          "strand": true,
          "transcript": "NM_001393512.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1322,
          "aa_ref": "A",
          "aa_start": 674,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 6109,
          "cdna_start": 2201,
          "cds_end": null,
          "cds_length": 3969,
          "cds_start": 2022,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 27,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "NM_001393513.1",
          "gene_hgnc_id": 19036,
          "gene_symbol": "MAST3",
          "hgvs_c": "c.2022T>A",
          "hgvs_p": "p.Ala674Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001380442.1",
          "strand": true,
          "transcript": "NM_001393513.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1318,
          "aa_ref": "A",
          "aa_start": 661,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5933,
          "cdna_start": 1998,
          "cds_end": null,
          "cds_length": 3957,
          "cds_start": 1983,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 27,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "NM_001393514.1",
          "gene_hgnc_id": 19036,
          "gene_symbol": "MAST3",
          "hgvs_c": "c.1983T>A",
          "hgvs_p": "p.Ala661Ala",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001380443.1",
          "strand": true,
          "transcript": "NM_001393514.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "A",
          "aa_end": null,
          "aa_length": 1318,
          "aa_ref": "A",
          "aa_start": 661,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 5967,
          "cdna_start": 2027,
          "cds_end": null,
          "cds_length": 3957,
          "cds_start": 1983,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 27,
          "exon_rank": 18,
          "exon_rank_end": null,
          "feature": "ENST00000893415.1",
          "gene_hgnc_id": 19036,
          "gene_symbol": "MAST3",
          "hgvs_c": "c.1983T>A",
          "hgvs_p": "p.Ala661Ala",
          "intron_rank": null,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.