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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 19-2102191-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=2102191&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "19",
      "pos": 2102191,
      "ref": "C",
      "alt": "T",
      "effect": "synonymous_variant",
      "transcript": "NM_001261826.3",
      "consequences": [
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "c.3630G>A",
          "hgvs_p": "p.Ala1210Ala",
          "transcript": "NM_001261826.3",
          "protein_id": "NP_001248755.1",
          "transcript_support_level": null,
          "aa_start": 1210,
          "aa_end": null,
          "aa_length": 1215,
          "cds_start": 3630,
          "cds_end": null,
          "cds_length": 3648,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000643116.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001261826.3"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "c.3630G>A",
          "hgvs_p": "p.Ala1210Ala",
          "transcript": "ENST00000643116.3",
          "protein_id": "ENSP00000495274.2",
          "transcript_support_level": null,
          "aa_start": 1210,
          "aa_end": null,
          "aa_length": 1215,
          "cds_start": 3630,
          "cds_end": null,
          "cds_length": 3648,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_001261826.3",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000643116.3"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 30,
          "exon_rank_end": null,
          "exon_count": 30,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "c.3444G>A",
          "hgvs_p": "p.Ala1148Ala",
          "transcript": "ENST00000345016.9",
          "protein_id": "ENSP00000344055.4",
          "transcript_support_level": 1,
          "aa_start": 1148,
          "aa_end": null,
          "aa_length": 1153,
          "cds_start": 3444,
          "cds_end": null,
          "cds_length": 3462,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000345016.9"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "n.867G>A",
          "hgvs_p": null,
          "transcript": "ENST00000591650.1",
          "protein_id": null,
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000591650.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "c.3711G>A",
          "hgvs_p": "p.Ala1237Ala",
          "transcript": "ENST00000920155.1",
          "protein_id": "ENSP00000590214.1",
          "transcript_support_level": null,
          "aa_start": 1237,
          "aa_end": null,
          "aa_length": 1242,
          "cds_start": 3711,
          "cds_end": null,
          "cds_length": 3729,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000920155.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "c.3636G>A",
          "hgvs_p": "p.Ala1212Ala",
          "transcript": "ENST00000920151.1",
          "protein_id": "ENSP00000590210.1",
          "transcript_support_level": null,
          "aa_start": 1212,
          "aa_end": null,
          "aa_length": 1217,
          "cds_start": 3636,
          "cds_end": null,
          "cds_length": 3654,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000920151.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 33,
          "exon_rank_end": null,
          "exon_count": 33,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "c.3630G>A",
          "hgvs_p": "p.Ala1210Ala",
          "transcript": "ENST00000964681.1",
          "protein_id": "ENSP00000634740.1",
          "transcript_support_level": null,
          "aa_start": 1210,
          "aa_end": null,
          "aa_length": 1215,
          "cds_start": 3630,
          "cds_end": null,
          "cds_length": 3648,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000964681.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "c.3603G>A",
          "hgvs_p": "p.Ala1201Ala",
          "transcript": "ENST00000920160.1",
          "protein_id": "ENSP00000590219.1",
          "transcript_support_level": null,
          "aa_start": 1201,
          "aa_end": null,
          "aa_length": 1206,
          "cds_start": 3603,
          "cds_end": null,
          "cds_length": 3621,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000920160.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "c.3594G>A",
          "hgvs_p": "p.Ala1198Ala",
          "transcript": "NM_001374799.1",
          "protein_id": "NP_001361728.1",
          "transcript_support_level": null,
          "aa_start": 1198,
          "aa_end": null,
          "aa_length": 1203,
          "cds_start": 3594,
          "cds_end": null,
          "cds_length": 3612,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001374799.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "c.3594G>A",
          "hgvs_p": "p.Ala1198Ala",
          "transcript": "ENST00000700387.1",
          "protein_id": "ENSP00000514969.1",
          "transcript_support_level": null,
          "aa_start": 1198,
          "aa_end": null,
          "aa_length": 1203,
          "cds_start": 3594,
          "cds_end": null,
          "cds_length": 3612,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000700387.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "c.3588G>A",
          "hgvs_p": "p.Ala1196Ala",
          "transcript": "ENST00000920154.1",
          "protein_id": "ENSP00000590213.1",
          "transcript_support_level": null,
          "aa_start": 1196,
          "aa_end": null,
          "aa_length": 1201,
          "cds_start": 3588,
          "cds_end": null,
          "cds_length": 3606,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000920154.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "c.3582G>A",
          "hgvs_p": "p.Ala1194Ala",
          "transcript": "ENST00000873634.1",
          "protein_id": "ENSP00000543693.1",
          "transcript_support_level": null,
          "aa_start": 1194,
          "aa_end": null,
          "aa_length": 1199,
          "cds_start": 3582,
          "cds_end": null,
          "cds_length": 3600,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000873634.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "c.3564G>A",
          "hgvs_p": "p.Ala1188Ala",
          "transcript": "ENST00000873633.1",
          "protein_id": "ENSP00000543692.1",
          "transcript_support_level": null,
          "aa_start": 1188,
          "aa_end": null,
          "aa_length": 1193,
          "cds_start": 3564,
          "cds_end": null,
          "cds_length": 3582,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000873633.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "c.3561G>A",
          "hgvs_p": "p.Ala1187Ala",
          "transcript": "ENST00000920159.1",
          "protein_id": "ENSP00000590218.1",
          "transcript_support_level": null,
          "aa_start": 1187,
          "aa_end": null,
          "aa_length": 1192,
          "cds_start": 3561,
          "cds_end": null,
          "cds_length": 3579,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000920159.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 32,
          "exon_rank_end": null,
          "exon_count": 32,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "c.3552G>A",
          "hgvs_p": "p.Ala1184Ala",
          "transcript": "ENST00000920152.1",
          "protein_id": "ENSP00000590211.1",
          "transcript_support_level": null,
          "aa_start": 1184,
          "aa_end": null,
          "aa_length": 1189,
          "cds_start": 3552,
          "cds_end": null,
          "cds_length": 3570,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000920152.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 31,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "c.3522G>A",
          "hgvs_p": "p.Ala1174Ala",
          "transcript": "ENST00000873635.1",
          "protein_id": "ENSP00000543694.1",
          "transcript_support_level": null,
          "aa_start": 1174,
          "aa_end": null,
          "aa_length": 1179,
          "cds_start": 3522,
          "cds_end": null,
          "cds_length": 3540,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000873635.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 31,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "c.3522G>A",
          "hgvs_p": "p.Ala1174Ala",
          "transcript": "ENST00000920156.1",
          "protein_id": "ENSP00000590215.1",
          "transcript_support_level": null,
          "aa_start": 1174,
          "aa_end": null,
          "aa_length": 1179,
          "cds_start": 3522,
          "cds_end": null,
          "cds_length": 3540,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000920156.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 31,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "c.3513G>A",
          "hgvs_p": "p.Ala1171Ala",
          "transcript": "ENST00000920153.1",
          "protein_id": "ENSP00000590212.1",
          "transcript_support_level": null,
          "aa_start": 1171,
          "aa_end": null,
          "aa_length": 1176,
          "cds_start": 3513,
          "cds_end": null,
          "cds_length": 3531,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000920153.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 31,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "c.3501G>A",
          "hgvs_p": "p.Ala1167Ala",
          "transcript": "ENST00000920158.1",
          "protein_id": "ENSP00000590217.1",
          "transcript_support_level": null,
          "aa_start": 1167,
          "aa_end": null,
          "aa_length": 1172,
          "cds_start": 3501,
          "cds_end": null,
          "cds_length": 3519,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000920158.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "A",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_rank": 31,
          "exon_rank_end": null,
          "exon_count": 31,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "AP3D1",
          "gene_hgnc_id": 568,
          "hgvs_c": "c.3486G>A",
          "hgvs_p": "p.Ala1162Ala",
          "transcript": "ENST00000920150.1",
          "protein_id": "ENSP00000590209.1",
          "transcript_support_level": null,
          "aa_start": 1162,
          "aa_end": null,
          "aa_length": 1167,
          "cds_start": 3486,
          "cds_end": null,
          "cds_length": 3504,
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        {
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          "protein_id": "ENSP00000466267.1",
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      ],
      "gene_symbol": "AP3D1",
      "gene_hgnc_id": 568,
      "dbsnp": "rs761320538",
      "frequency_reference_population": 0.000004105124,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 6,
      "gnomad_exomes_af": 0.00000410512,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": 6,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": -0.6899999976158142,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "BayesDel_noAF",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": null,
      "revel_prediction": null,
      "alphamissense_score": null,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.69,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": -0.059,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -5,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "PM2,BP4_Strong,BP6_Moderate,BP7",
      "acmg_by_gene": [
        {
          "score": -5,
          "benign_score": 7,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Strong",
            "BP6_Moderate",
            "BP7"
          ],
          "verdict": "Likely_benign",
          "transcript": "NM_001261826.3",
          "gene_symbol": "AP3D1",
          "hgnc_id": 568,
          "effects": [
            "synonymous_variant"
          ],
          "inheritance_mode": "Unknown,AR",
          "hgvs_c": "c.3630G>A",
          "hgvs_p": "p.Ala1210Ala"
        }
      ],
      "clinvar_disease": "not provided",
      "clinvar_classification": "Likely benign",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "LB:1",
      "phenotype_combined": "not provided",
      "pathogenicity_classification_combined": "Likely benign",
      "custom_annotations": null
    }
  ],
  "message": null
}