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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 19-34177389-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=34177389&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "19",
"pos": 34177389,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000544216.8",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LSM14A",
"gene_hgnc_id": 24489,
"hgvs_c": "c.121+4626T>C",
"hgvs_p": null,
"transcript": "NM_015578.4",
"protein_id": "NP_056393.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 463,
"cds_start": -4,
"cds_end": null,
"cds_length": 1392,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3431,
"mane_select": "ENST00000544216.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LSM14A",
"gene_hgnc_id": 24489,
"hgvs_c": "c.121+4626T>C",
"hgvs_p": null,
"transcript": "ENST00000544216.8",
"protein_id": "ENSP00000446271.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 463,
"cds_start": -4,
"cds_end": null,
"cds_length": 1392,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3431,
"mane_select": "NM_015578.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LSM14A",
"gene_hgnc_id": 24489,
"hgvs_c": "c.121+4626T>C",
"hgvs_p": null,
"transcript": "ENST00000433627.9",
"protein_id": "ENSP00000413964.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 463,
"cds_start": -4,
"cds_end": null,
"cds_length": 1392,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3424,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LSM14A",
"gene_hgnc_id": 24489,
"hgvs_c": "c.121+4626T>C",
"hgvs_p": null,
"transcript": "NM_001384420.1",
"protein_id": "NP_001371349.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 468,
"cds_start": -4,
"cds_end": null,
"cds_length": 1407,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3427,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LSM14A",
"gene_hgnc_id": 24489,
"hgvs_c": "c.121+4626T>C",
"hgvs_p": null,
"transcript": "NM_001114093.3",
"protein_id": "NP_001107565.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 463,
"cds_start": -4,
"cds_end": null,
"cds_length": 1392,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3488,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LSM14A",
"gene_hgnc_id": 24489,
"hgvs_c": "c.121+4626T>C",
"hgvs_p": null,
"transcript": "NM_001384421.1",
"protein_id": "NP_001371350.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 461,
"cds_start": -4,
"cds_end": null,
"cds_length": 1386,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3425,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LSM14A",
"gene_hgnc_id": 24489,
"hgvs_c": "c.121+4626T>C",
"hgvs_p": null,
"transcript": "NM_001384422.1",
"protein_id": "NP_001371351.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 452,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 3398,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LSM14A",
"gene_hgnc_id": 24489,
"hgvs_c": "c.121+4626T>C",
"hgvs_p": null,
"transcript": "NM_001384423.1",
"protein_id": "NP_001371352.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 422,
"cds_start": -4,
"cds_end": null,
"cds_length": 1269,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3365,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "LSM14A",
"gene_hgnc_id": 24489,
"hgvs_c": "c.121+4626T>C",
"hgvs_p": null,
"transcript": "ENST00000540746.6",
"protein_id": "ENSP00000446451.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 422,
"cds_start": -4,
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"cds_length": 1269,
"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 9,
"intron_rank": 1,
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"gene_symbol": "LSM14A",
"gene_hgnc_id": 24489,
"hgvs_c": "c.121+4626T>C",
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"transcript": "NM_001384424.1",
"protein_id": "NP_001371353.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"intron_rank": 1,
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"gene_symbol": "LSM14A",
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"hgvs_c": "c.121+4626T>C",
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"transcript": "NM_001384425.1",
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},
{
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],
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},
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],
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"gene_symbol": "LSM14A",
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},
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"gene_symbol": "LSM14A",
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},
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],
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"gene_symbol": "LSM14A",
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},
{
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],
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"gene_symbol": "LSM14A",
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"hgvs_c": "c.-303+4626T>C",
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],
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"gene_symbol": "LSM14A",
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},
{
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],
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"gene_symbol": "LSM14A",
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"hgvs_c": "c.106+4626T>C",
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