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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 19-35009198-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=35009198&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "19",
"pos": 35009198,
"ref": "C",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_001320036.2",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "NM_020895.5",
"protein_id": "NP_065946.2",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 724,
"cds_start": 88,
"cds_end": null,
"cds_length": 2175,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000317991.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_020895.5"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "ENST00000317991.10",
"protein_id": "ENSP00000441032.1",
"transcript_support_level": 1,
"aa_start": 30,
"aa_end": null,
"aa_length": 724,
"cds_start": 88,
"cds_end": null,
"cds_length": 2175,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_020895.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000317991.10"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.349C>G",
"hgvs_p": "p.Arg117Gly",
"transcript": "ENST00000599564.5",
"protein_id": "ENSP00000470220.1",
"transcript_support_level": 5,
"aa_start": 117,
"aa_end": null,
"aa_length": 807,
"cds_start": 349,
"cds_end": null,
"cds_length": 2424,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000599564.5"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.349C>G",
"hgvs_p": "p.Arg117Gly",
"transcript": "NM_001320036.2",
"protein_id": "NP_001306965.1",
"transcript_support_level": null,
"aa_start": 117,
"aa_end": null,
"aa_length": 806,
"cds_start": 349,
"cds_end": null,
"cds_length": 2421,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001320036.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "ENST00000942874.1",
"protein_id": "ENSP00000612933.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 758,
"cds_start": 88,
"cds_end": null,
"cds_length": 2277,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942874.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "ENST00000940004.1",
"protein_id": "ENSP00000610063.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 733,
"cds_start": 88,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940004.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "ENST00000942865.1",
"protein_id": "ENSP00000612924.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 723,
"cds_start": 88,
"cds_end": null,
"cds_length": 2172,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942865.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "NM_001320034.2",
"protein_id": "NP_001306963.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 720,
"cds_start": 88,
"cds_end": null,
"cds_length": 2163,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001320034.2"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "ENST00000680623.1",
"protein_id": "ENSP00000505404.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 720,
"cds_start": 88,
"cds_end": null,
"cds_length": 2163,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000680623.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "ENST00000942870.1",
"protein_id": "ENSP00000612929.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 719,
"cds_start": 88,
"cds_end": null,
"cds_length": 2160,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942870.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "ENST00000942869.1",
"protein_id": "ENSP00000612928.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 716,
"cds_start": 88,
"cds_end": null,
"cds_length": 2151,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942869.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "NM_001136199.3",
"protein_id": "NP_001129671.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 713,
"cds_start": 88,
"cds_end": null,
"cds_length": 2142,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001136199.3"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "ENST00000411896.6",
"protein_id": "ENSP00000439267.1",
"transcript_support_level": 2,
"aa_start": 30,
"aa_end": null,
"aa_length": 713,
"cds_start": 88,
"cds_end": null,
"cds_length": 2142,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000411896.6"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "ENST00000942873.1",
"protein_id": "ENSP00000612932.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 710,
"cds_start": 88,
"cds_end": null,
"cds_length": 2133,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942873.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "ENST00000940005.1",
"protein_id": "ENSP00000610064.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 703,
"cds_start": 88,
"cds_end": null,
"cds_length": 2112,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940005.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "ENST00000942867.1",
"protein_id": "ENSP00000612926.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 702,
"cds_start": 88,
"cds_end": null,
"cds_length": 2109,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942867.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "ENST00000942871.1",
"protein_id": "ENSP00000612930.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 702,
"cds_start": 88,
"cds_end": null,
"cds_length": 2109,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942871.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "ENST00000942866.1",
"protein_id": "ENSP00000612925.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 698,
"cds_start": 88,
"cds_end": null,
"cds_length": 2097,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942866.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "ENST00000942868.1",
"protein_id": "ENSP00000612927.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 672,
"cds_start": 88,
"cds_end": null,
"cds_length": 2019,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942868.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "ENST00000940006.1",
"protein_id": "ENSP00000610065.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 665,
"cds_start": 88,
"cds_end": null,
"cds_length": 1998,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940006.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "ENST00000942872.1",
"protein_id": "ENSP00000612931.1",
"transcript_support_level": null,
"aa_start": 30,
"aa_end": null,
"aa_length": 526,
"cds_start": 88,
"cds_end": null,
"cds_length": 1581,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942872.1"
},
{
"aa_ref": "R",
"aa_alt": "G",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.88C>G",
"hgvs_p": "p.Arg30Gly",
"transcript": "ENST00000424536.2",
"protein_id": "ENSP00000474401.1",
"transcript_support_level": 2,
"aa_start": 30,
"aa_end": null,
"aa_length": 205,
"cds_start": 88,
"cds_end": null,
"cds_length": 618,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
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"feature": "ENST00000424536.2"
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}
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}