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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 19-35015825-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=35015825&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "19",
"pos": 35015825,
"ref": "G",
"alt": "C",
"effect": "splice_acceptor_variant,intron_variant",
"transcript": "NM_001320036.2",
"consequences": [
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.1071G>C",
"hgvs_p": "p.Ala357Ala",
"transcript": "NM_020895.5",
"protein_id": "NP_065946.2",
"transcript_support_level": null,
"aa_start": 357,
"aa_end": null,
"aa_length": 724,
"cds_start": 1071,
"cds_end": null,
"cds_length": 2175,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000317991.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_020895.5"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.1071G>C",
"hgvs_p": "p.Ala357Ala",
"transcript": "ENST00000317991.10",
"protein_id": "ENSP00000441032.1",
"transcript_support_level": 1,
"aa_start": 357,
"aa_end": null,
"aa_length": 724,
"cds_start": 1071,
"cds_end": null,
"cds_length": 2175,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_020895.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000317991.10"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "n.857G>C",
"hgvs_p": null,
"transcript": "ENST00000598118.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000598118.1"
},
{
"aa_ref": "R",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant",
"splice_region_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.608G>C",
"hgvs_p": "p.Arg203Pro",
"transcript": "ENST00000942872.1",
"protein_id": "ENSP00000612931.1",
"transcript_support_level": null,
"aa_start": 203,
"aa_end": null,
"aa_length": 526,
"cds_start": 608,
"cds_end": null,
"cds_length": 1581,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942872.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.1332G>C",
"hgvs_p": "p.Ala444Ala",
"transcript": "ENST00000599564.5",
"protein_id": "ENSP00000470220.1",
"transcript_support_level": 5,
"aa_start": 444,
"aa_end": null,
"aa_length": 807,
"cds_start": 1332,
"cds_end": null,
"cds_length": 2424,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000599564.5"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.1071G>C",
"hgvs_p": "p.Ala357Ala",
"transcript": "ENST00000942874.1",
"protein_id": "ENSP00000612933.1",
"transcript_support_level": null,
"aa_start": 357,
"aa_end": null,
"aa_length": 758,
"cds_start": 1071,
"cds_end": null,
"cds_length": 2277,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942874.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.1050G>C",
"hgvs_p": "p.Ala350Ala",
"transcript": "ENST00000940004.1",
"protein_id": "ENSP00000610063.1",
"transcript_support_level": null,
"aa_start": 350,
"aa_end": null,
"aa_length": 733,
"cds_start": 1050,
"cds_end": null,
"cds_length": 2202,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940004.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.1071G>C",
"hgvs_p": "p.Ala357Ala",
"transcript": "ENST00000942865.1",
"protein_id": "ENSP00000612924.1",
"transcript_support_level": null,
"aa_start": 357,
"aa_end": null,
"aa_length": 723,
"cds_start": 1071,
"cds_end": null,
"cds_length": 2172,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942865.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.1071G>C",
"hgvs_p": "p.Ala357Ala",
"transcript": "NM_001320034.2",
"protein_id": "NP_001306963.1",
"transcript_support_level": null,
"aa_start": 357,
"aa_end": null,
"aa_length": 720,
"cds_start": 1071,
"cds_end": null,
"cds_length": 2163,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001320034.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.1071G>C",
"hgvs_p": "p.Ala357Ala",
"transcript": "ENST00000680623.1",
"protein_id": "ENSP00000505404.1",
"transcript_support_level": null,
"aa_start": 357,
"aa_end": null,
"aa_length": 720,
"cds_start": 1071,
"cds_end": null,
"cds_length": 2163,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000680623.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.1068G>C",
"hgvs_p": "p.Ala356Ala",
"transcript": "ENST00000942870.1",
"protein_id": "ENSP00000612929.1",
"transcript_support_level": null,
"aa_start": 356,
"aa_end": null,
"aa_length": 719,
"cds_start": 1068,
"cds_end": null,
"cds_length": 2160,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942870.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.1059G>C",
"hgvs_p": "p.Ala353Ala",
"transcript": "ENST00000942869.1",
"protein_id": "ENSP00000612928.1",
"transcript_support_level": null,
"aa_start": 353,
"aa_end": null,
"aa_length": 716,
"cds_start": 1059,
"cds_end": null,
"cds_length": 2151,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942869.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.1050G>C",
"hgvs_p": "p.Ala350Ala",
"transcript": "NM_001136199.3",
"protein_id": "NP_001129671.1",
"transcript_support_level": null,
"aa_start": 350,
"aa_end": null,
"aa_length": 713,
"cds_start": 1050,
"cds_end": null,
"cds_length": 2142,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001136199.3"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.1050G>C",
"hgvs_p": "p.Ala350Ala",
"transcript": "ENST00000411896.6",
"protein_id": "ENSP00000439267.1",
"transcript_support_level": 2,
"aa_start": 350,
"aa_end": null,
"aa_length": 713,
"cds_start": 1050,
"cds_end": null,
"cds_length": 2142,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000411896.6"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.1041G>C",
"hgvs_p": "p.Thr347Thr",
"transcript": "ENST00000942873.1",
"protein_id": "ENSP00000612932.1",
"transcript_support_level": null,
"aa_start": 347,
"aa_end": null,
"aa_length": 710,
"cds_start": 1041,
"cds_end": null,
"cds_length": 2133,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942873.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.1020G>C",
"hgvs_p": "p.Thr340Thr",
"transcript": "ENST00000940005.1",
"protein_id": "ENSP00000610064.1",
"transcript_support_level": null,
"aa_start": 340,
"aa_end": null,
"aa_length": 703,
"cds_start": 1020,
"cds_end": null,
"cds_length": 2112,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000940005.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.1071G>C",
"hgvs_p": "p.Ala357Ala",
"transcript": "ENST00000942867.1",
"protein_id": "ENSP00000612926.1",
"transcript_support_level": null,
"aa_start": 357,
"aa_end": null,
"aa_length": 702,
"cds_start": 1071,
"cds_end": null,
"cds_length": 2109,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942867.1"
},
{
"aa_ref": "T",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.1017G>C",
"hgvs_p": "p.Thr339Thr",
"transcript": "ENST00000942871.1",
"protein_id": "ENSP00000612930.1",
"transcript_support_level": null,
"aa_start": 339,
"aa_end": null,
"aa_length": 702,
"cds_start": 1017,
"cds_end": null,
"cds_length": 2109,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942871.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.1071G>C",
"hgvs_p": "p.Ala357Ala",
"transcript": "ENST00000942866.1",
"protein_id": "ENSP00000612925.1",
"transcript_support_level": null,
"aa_start": 357,
"aa_end": null,
"aa_length": 698,
"cds_start": 1071,
"cds_end": null,
"cds_length": 2097,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942866.1"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.369G>C",
"hgvs_p": "p.Ala123Ala",
"transcript": "NM_001320035.2",
"protein_id": "NP_001306964.1",
"transcript_support_level": null,
"aa_start": 123,
"aa_end": null,
"aa_length": 486,
"cds_start": 369,
"cds_end": null,
"cds_length": 1461,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001320035.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "GRAMD1A",
"gene_hgnc_id": 29305,
"hgvs_c": "c.1332G>C",
"hgvs_p": "p.Ala444Ala",
"transcript": "XM_011527153.2",
"protein_id": "XP_011525455.1",
"transcript_support_level": null,
"aa_start": 444,
"aa_end": null,
"aa_length": 811,
"cds_start": 1332,
"cds_end": null,
"cds_length": 2436,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011527153.2"
},
{
"aa_ref": "A",
"aa_alt": "A",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_region_variant",
"synonymous_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 19,
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{
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"PM2"
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{
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],
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}
],
"message": null
}