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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 19-3526130-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=3526130&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "19",
"pos": 3526130,
"ref": "A",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_001136198.1",
"consequences": [
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "NM_016263.4",
"protein_id": "NP_057347.2",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 493,
"cds_start": 206,
"cds_end": null,
"cds_length": 1482,
"cdna_start": 404,
"cdna_end": null,
"cdna_length": 5178,
"mane_select": "ENST00000441788.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_016263.4"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000441788.7",
"protein_id": "ENSP00000410369.1",
"transcript_support_level": 1,
"aa_start": 69,
"aa_end": null,
"aa_length": 493,
"cds_start": 206,
"cds_end": null,
"cds_length": 1482,
"cdna_start": 404,
"cdna_end": null,
"cdna_length": 5178,
"mane_select": "NM_016263.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000441788.7"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000395095.7",
"protein_id": "ENSP00000378529.2",
"transcript_support_level": 1,
"aa_start": 69,
"aa_end": null,
"aa_length": 496,
"cds_start": 206,
"cds_end": null,
"cds_length": 1491,
"cdna_start": 206,
"cdna_end": null,
"cdna_length": 1491,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000395095.7"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000313639.8",
"protein_id": "ENSP00000321800.7",
"transcript_support_level": 1,
"aa_start": 69,
"aa_end": null,
"aa_length": 404,
"cds_start": 206,
"cds_end": null,
"cds_length": 1215,
"cdna_start": 206,
"cdna_end": null,
"cdna_length": 1215,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000313639.8"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000928283.1",
"protein_id": "ENSP00000598342.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 536,
"cds_start": 206,
"cds_end": null,
"cds_length": 1611,
"cdna_start": 419,
"cdna_end": null,
"cdna_length": 3180,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000928283.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000876601.1",
"protein_id": "ENSP00000546660.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 533,
"cds_start": 206,
"cds_end": null,
"cds_length": 1602,
"cdna_start": 398,
"cdna_end": null,
"cdna_length": 3151,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876601.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000876599.1",
"protein_id": "ENSP00000546658.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 515,
"cds_start": 206,
"cds_end": null,
"cds_length": 1548,
"cdna_start": 417,
"cdna_end": null,
"cdna_length": 3117,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876599.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "NM_001136198.1",
"protein_id": "NP_001129670.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 496,
"cds_start": 206,
"cds_end": null,
"cds_length": 1491,
"cdna_start": 240,
"cdna_end": null,
"cdna_length": 3446,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001136198.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000652521.1",
"protein_id": "ENSP00000498659.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 493,
"cds_start": 206,
"cds_end": null,
"cds_length": 1482,
"cdna_start": 1061,
"cdna_end": null,
"cdna_length": 3503,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000652521.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000876600.1",
"protein_id": "ENSP00000546659.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 493,
"cds_start": 206,
"cds_end": null,
"cds_length": 1482,
"cdna_start": 484,
"cdna_end": null,
"cdna_length": 3118,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876600.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000876604.1",
"protein_id": "ENSP00000546663.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 493,
"cds_start": 206,
"cds_end": null,
"cds_length": 1482,
"cdna_start": 522,
"cdna_end": null,
"cdna_length": 1966,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876604.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000876605.1",
"protein_id": "ENSP00000546664.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 493,
"cds_start": 206,
"cds_end": null,
"cds_length": 1482,
"cdna_start": 995,
"cdna_end": null,
"cdna_length": 3622,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876605.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000928282.1",
"protein_id": "ENSP00000598341.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 493,
"cds_start": 206,
"cds_end": null,
"cds_length": 1482,
"cdna_start": 548,
"cdna_end": null,
"cdna_length": 5316,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000928282.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000928284.1",
"protein_id": "ENSP00000598343.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 493,
"cds_start": 206,
"cds_end": null,
"cds_length": 1482,
"cdna_start": 636,
"cdna_end": null,
"cdna_length": 2082,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000928284.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000928286.1",
"protein_id": "ENSP00000598345.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 493,
"cds_start": 206,
"cds_end": null,
"cds_length": 1482,
"cdna_start": 1004,
"cdna_end": null,
"cdna_length": 3631,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000928286.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000951911.1",
"protein_id": "ENSP00000621970.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 493,
"cds_start": 206,
"cds_end": null,
"cds_length": 1482,
"cdna_start": 535,
"cdna_end": null,
"cdna_length": 3731,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951911.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000951912.1",
"protein_id": "ENSP00000621971.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 493,
"cds_start": 206,
"cds_end": null,
"cds_length": 1482,
"cdna_start": 472,
"cdna_end": null,
"cdna_length": 3104,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951912.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000951913.1",
"protein_id": "ENSP00000621972.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 493,
"cds_start": 206,
"cds_end": null,
"cds_length": 1482,
"cdna_start": 377,
"cdna_end": null,
"cdna_length": 2540,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951913.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000876603.1",
"protein_id": "ENSP00000546662.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 475,
"cds_start": 206,
"cds_end": null,
"cds_length": 1428,
"cdna_start": 404,
"cdna_end": null,
"cdna_length": 1796,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876603.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000876598.1",
"protein_id": "ENSP00000546657.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 472,
"cds_start": 206,
"cds_end": null,
"cds_length": 1419,
"cdna_start": 438,
"cdna_end": null,
"cdna_length": 3563,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876598.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000876602.1",
"protein_id": "ENSP00000546661.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 472,
"cds_start": 206,
"cds_end": null,
"cds_length": 1419,
"cdna_start": 552,
"cdna_end": null,
"cdna_length": 3115,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876602.1"
},
{
"aa_ref": "K",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "FZR1",
"gene_hgnc_id": 24824,
"hgvs_c": "c.206A>G",
"hgvs_p": "p.Lys69Arg",
"transcript": "ENST00000928285.1",
"protein_id": "ENSP00000598344.1",
"transcript_support_level": null,
"aa_start": 69,
"aa_end": null,
"aa_length": 415,
"cds_start": 206,
"cds_end": null,
"cds_length": 1248,
"cdna_start": 398,
"cdna_end": null,
"cdna_length": 1611,
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}
],
"message": null
}