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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 19-35513144-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=35513144&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "19",
"pos": 35513144,
"ref": "T",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_033317.5",
"consequences": [
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "NM_033317.5",
"protein_id": "NP_201574.4",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 476,
"cds_start": 332,
"cds_end": null,
"cds_length": 1431,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000339686.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_033317.5"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "ENST00000339686.8",
"protein_id": "ENSP00000342012.3",
"transcript_support_level": 1,
"aa_start": 111,
"aa_end": null,
"aa_length": 476,
"cds_start": 332,
"cds_end": null,
"cds_length": 1431,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_033317.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000339686.8"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "ENST00000419602.5",
"protein_id": "ENSP00000391036.1",
"transcript_support_level": 1,
"aa_start": 111,
"aa_end": null,
"aa_length": 465,
"cds_start": 332,
"cds_end": null,
"cds_length": 1398,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000419602.5"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "ENST00000429837.5",
"protein_id": "ENSP00000405503.1",
"transcript_support_level": 1,
"aa_start": 111,
"aa_end": null,
"aa_length": 449,
"cds_start": 332,
"cds_end": null,
"cds_length": 1350,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000429837.5"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "ENST00000447113.6",
"protein_id": "ENSP00000394908.2",
"transcript_support_level": 1,
"aa_start": 111,
"aa_end": null,
"aa_length": 436,
"cds_start": 332,
"cds_end": null,
"cds_length": 1311,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000447113.6"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "ENST00000424570.6",
"protein_id": "ENSP00000388404.2",
"transcript_support_level": 1,
"aa_start": 111,
"aa_end": null,
"aa_length": 398,
"cds_start": 332,
"cds_end": null,
"cds_length": 1197,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000424570.6"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "ENST00000418261.5",
"protein_id": "ENSP00000414743.1",
"transcript_support_level": 1,
"aa_start": 111,
"aa_end": null,
"aa_length": 386,
"cds_start": 332,
"cds_end": null,
"cds_length": 1161,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000418261.5"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "ENST00000451297.6",
"protein_id": "ENSP00000409513.2",
"transcript_support_level": 1,
"aa_start": 111,
"aa_end": null,
"aa_length": 369,
"cds_start": 332,
"cds_end": null,
"cds_length": 1110,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000451297.6"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "ENST00000875014.1",
"protein_id": "ENSP00000545073.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 476,
"cds_start": 332,
"cds_end": null,
"cds_length": 1431,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000875014.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "NM_001126056.3",
"protein_id": "NP_001119528.3",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 465,
"cds_start": 332,
"cds_end": null,
"cds_length": 1398,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001126056.3"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "ENST00000933306.1",
"protein_id": "ENSP00000603365.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 457,
"cds_start": 332,
"cds_end": null,
"cds_length": 1374,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000933306.1"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "NM_001190347.2",
"protein_id": "NP_001177276.2",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 449,
"cds_start": 332,
"cds_end": null,
"cds_length": 1350,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001190347.2"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "NM_001190348.2",
"protein_id": "NP_001177277.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 436,
"cds_start": 332,
"cds_end": null,
"cds_length": 1311,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001190348.2"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "NM_001126057.3",
"protein_id": "NP_001119529.2",
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"aa_end": null,
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"cds_start": 332,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001126057.3"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "NM_001126058.3",
"protein_id": "NP_001119530.2",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 386,
"cds_start": 332,
"cds_end": null,
"cds_length": 1161,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001126058.3"
},
{
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"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
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"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "NM_001190349.2",
"protein_id": "NP_001177278.1",
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"cds_start": 332,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001190349.2"
},
{
"aa_ref": "H",
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "XM_047439685.1",
"protein_id": "XP_047295641.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 540,
"cds_start": 332,
"cds_end": null,
"cds_length": 1623,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047439685.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "XM_011527495.3",
"protein_id": "XP_011525797.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 538,
"cds_start": 332,
"cds_end": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011527495.3"
},
{
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"protein_coding": true,
"strand": false,
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],
"exon_rank": 1,
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"exon_count": 21,
"intron_rank": null,
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"gene_symbol": "DMKN",
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"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "XM_011527497.3",
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"biotype": "protein_coding",
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
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"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DMKN",
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"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "XM_011527498.3",
"protein_id": "XP_011525800.1",
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"biotype": "protein_coding",
"feature": "XM_011527498.3"
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
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"intron_rank": null,
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"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "XM_011527500.3",
"protein_id": "XP_011525802.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 520,
"cds_start": 332,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011527500.3"
},
{
"aa_ref": "H",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DMKN",
"gene_hgnc_id": 25063,
"hgvs_c": "c.332A>G",
"hgvs_p": "p.His111Arg",
"transcript": "XM_011527501.3",
"protein_id": "XP_011525803.1",
"transcript_support_level": null,
"aa_start": 111,
"aa_end": null,
"aa_length": 518,
"cds_start": 332,
"cds_end": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011527501.3"
},
{
"aa_ref": "H",
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
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}
],
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}