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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 19-36712784-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=36712784&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "19",
      "pos": 36712784,
      "ref": "G",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "NM_001387759.1",
      "consequences": [
        {
          "aa_ref": "C",
          "aa_alt": "Y",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.140G>A",
          "hgvs_p": "p.Cys47Tyr",
          "transcript": "NM_001322917.1",
          "protein_id": "NP_001309846.1",
          "transcript_support_level": null,
          "aa_start": 47,
          "aa_end": null,
          "aa_length": 647,
          "cds_start": 140,
          "cds_end": null,
          "cds_length": 1944,
          "cdna_start": 330,
          "cdna_end": null,
          "cdna_length": 2802,
          "mane_select": "ENST00000682579.1",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001322917.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "Y",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.140G>A",
          "hgvs_p": "p.Cys47Tyr",
          "transcript": "ENST00000682579.1",
          "protein_id": "ENSP00000507048.1",
          "transcript_support_level": null,
          "aa_start": 47,
          "aa_end": null,
          "aa_length": 647,
          "cds_start": 140,
          "cds_end": null,
          "cds_length": 1944,
          "cdna_start": 330,
          "cdna_end": null,
          "cdna_length": 2802,
          "mane_select": "NM_001322917.1",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000682579.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "Y",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.47G>A",
          "hgvs_p": "p.Cys16Tyr",
          "transcript": "ENST00000360729.8",
          "protein_id": "ENSP00000353957.3",
          "transcript_support_level": 1,
          "aa_start": 16,
          "aa_end": null,
          "aa_length": 616,
          "cds_start": 47,
          "cds_end": null,
          "cds_length": 1851,
          "cdna_start": 229,
          "cdna_end": null,
          "cdna_length": 2691,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000360729.8"
        },
        {
          "aa_ref": "C",
          "aa_alt": "Y",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.47G>A",
          "hgvs_p": "p.Cys16Tyr",
          "transcript": "ENST00000585696.5",
          "protein_id": "ENSP00000467379.1",
          "transcript_support_level": 1,
          "aa_start": 16,
          "aa_end": null,
          "aa_length": 616,
          "cds_start": 47,
          "cds_end": null,
          "cds_length": 1851,
          "cdna_start": 1277,
          "cdna_end": null,
          "cdna_length": 3734,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000585696.5"
        },
        {
          "aa_ref": "C",
          "aa_alt": "Y",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.209G>A",
          "hgvs_p": "p.Cys70Tyr",
          "transcript": "NM_001387759.1",
          "protein_id": "NP_001374688.1",
          "transcript_support_level": null,
          "aa_start": 70,
          "aa_end": null,
          "aa_length": 670,
          "cds_start": 209,
          "cds_end": null,
          "cds_length": 2013,
          "cdna_start": 451,
          "cdna_end": null,
          "cdna_length": 2923,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001387759.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "Y",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 7,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.209G>A",
          "hgvs_p": "p.Cys70Tyr",
          "transcript": "ENST00000910221.1",
          "protein_id": "ENSP00000580280.1",
          "transcript_support_level": null,
          "aa_start": 70,
          "aa_end": null,
          "aa_length": 670,
          "cds_start": 209,
          "cds_end": null,
          "cds_length": 2013,
          "cdna_start": 499,
          "cdna_end": null,
          "cdna_length": 2959,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000910221.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "Y",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.209G>A",
          "hgvs_p": "p.Cys70Tyr",
          "transcript": "ENST00000915758.1",
          "protein_id": "ENSP00000585817.1",
          "transcript_support_level": null,
          "aa_start": 70,
          "aa_end": null,
          "aa_length": 670,
          "cds_start": 209,
          "cds_end": null,
          "cds_length": 2013,
          "cdna_start": 397,
          "cdna_end": null,
          "cdna_length": 2857,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000915758.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "Y",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.140G>A",
          "hgvs_p": "p.Cys47Tyr",
          "transcript": "NM_001300979.2",
          "protein_id": "NP_001287908.1",
          "transcript_support_level": null,
          "aa_start": 47,
          "aa_end": null,
          "aa_length": 647,
          "cds_start": 140,
          "cds_end": null,
          "cds_length": 1944,
          "cdna_start": 378,
          "cdna_end": null,
          "cdna_length": 2850,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001300979.2"
        },
        {
          "aa_ref": "C",
          "aa_alt": "Y",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.140G>A",
          "hgvs_p": "p.Cys47Tyr",
          "transcript": "NM_001322913.1",
          "protein_id": "NP_001309842.1",
          "transcript_support_level": null,
          "aa_start": 47,
          "aa_end": null,
          "aa_length": 647,
          "cds_start": 140,
          "cds_end": null,
          "cds_length": 1944,
          "cdna_start": 382,
          "cdna_end": null,
          "cdna_length": 2854,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001322913.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "Y",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.140G>A",
          "hgvs_p": "p.Cys47Tyr",
          "transcript": "NM_001322914.1",
          "protein_id": "NP_001309843.1",
          "transcript_support_level": null,
          "aa_start": 47,
          "aa_end": null,
          "aa_length": 647,
          "cds_start": 140,
          "cds_end": null,
          "cds_length": 1944,
          "cdna_start": 554,
          "cdna_end": null,
          "cdna_length": 3026,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001322914.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "Y",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.140G>A",
          "hgvs_p": "p.Cys47Tyr",
          "transcript": "NM_001322915.1",
          "protein_id": "NP_001309844.1",
          "transcript_support_level": null,
          "aa_start": 47,
          "aa_end": null,
          "aa_length": 647,
          "cds_start": 140,
          "cds_end": null,
          "cds_length": 1944,
          "cdna_start": 450,
          "cdna_end": null,
          "cdna_length": 2922,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001322915.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "Y",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.140G>A",
          "hgvs_p": "p.Cys47Tyr",
          "transcript": "NM_001322916.1",
          "protein_id": "NP_001309845.1",
          "transcript_support_level": null,
          "aa_start": 47,
          "aa_end": null,
          "aa_length": 647,
          "cds_start": 140,
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          "cds_length": 1944,
          "cdna_start": 326,
          "cdna_end": null,
          "cdna_length": 2798,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001322916.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "Y",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
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          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.140G>A",
          "hgvs_p": "p.Cys47Tyr",
          "transcript": "NM_001322918.1",
          "protein_id": "NP_001309847.1",
          "transcript_support_level": null,
          "aa_start": 47,
          "aa_end": null,
          "aa_length": 647,
          "cds_start": 140,
          "cds_end": null,
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          "cdna_start": 454,
          "cdna_end": null,
          "cdna_length": 2926,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "NM_001322918.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "Y",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.140G>A",
          "hgvs_p": "p.Cys47Tyr",
          "transcript": "NM_001322919.1",
          "protein_id": "NP_001309848.1",
          "transcript_support_level": null,
          "aa_start": 47,
          "aa_end": null,
          "aa_length": 647,
          "cds_start": 140,
          "cds_end": null,
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          "cdna_start": 550,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "NM_001322919.1"
        },
        {
          "aa_ref": "C",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
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          "intron_rank": null,
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          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.140G>A",
          "hgvs_p": "p.Cys47Tyr",
          "transcript": "NM_001322920.1",
          "protein_id": "NP_001309849.1",
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          "cds_start": 140,
          "cds_end": null,
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          "cdna_start": 502,
          "cdna_end": null,
          "cdna_length": 2974,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "NM_001322920.1"
        },
        {
          "aa_ref": "C",
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          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
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          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.140G>A",
          "hgvs_p": "p.Cys47Tyr",
          "transcript": "NM_001387760.1",
          "protein_id": "NP_001374689.1",
          "transcript_support_level": null,
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          "aa_end": null,
          "aa_length": 647,
          "cds_start": 140,
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          "cdna_start": 501,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "NM_001387760.1"
        },
        {
          "aa_ref": "C",
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          "protein_coding": true,
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          ],
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          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
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          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.140G>A",
          "hgvs_p": "p.Cys47Tyr",
          "transcript": "NM_001387761.1",
          "protein_id": "NP_001374690.1",
          "transcript_support_level": null,
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        },
        {
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          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.140G>A",
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          "transcript": "NM_001387762.1",
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        },
        {
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          ],
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          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.140G>A",
          "hgvs_p": "p.Cys47Tyr",
          "transcript": "NM_001387763.1",
          "protein_id": "NP_001374692.1",
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          "cdna_length": 2753,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "NM_001387763.1"
        },
        {
          "aa_ref": "C",
          "aa_alt": "Y",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "ZNF567",
          "gene_hgnc_id": 28696,
          "hgvs_c": "c.140G>A",
          "hgvs_p": "p.Cys47Tyr",
          "transcript": "NM_001387764.1",
          "protein_id": "NP_001374693.1",
          "transcript_support_level": null,
          "aa_start": 47,
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          "cds_start": 140,
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          "cdna_start": 335,
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          "cdna_length": 2807,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "NM_001387764.1"
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      "clinvar_classification": "Uncertain significance",
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      "clinvar_submissions_summary": "US:1",
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      "custom_annotations": null
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  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.