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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 19-37091027-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=37091027&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "19",
"pos": 37091027,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_001329515.3",
"consequences": [
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "NM_144689.5",
"protein_id": "NP_653290.2",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 688,
"cds_start": 42,
"cds_end": null,
"cds_length": 2067,
"cdna_start": 304,
"cdna_end": null,
"cdna_length": 3639,
"mane_select": "ENST00000337995.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_144689.5"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "ENST00000337995.4",
"protein_id": "ENSP00000338770.2",
"transcript_support_level": 1,
"aa_start": 14,
"aa_end": null,
"aa_length": 688,
"cds_start": 42,
"cds_end": null,
"cds_length": 2067,
"cdna_start": 304,
"cdna_end": null,
"cdna_length": 3639,
"mane_select": "NM_144689.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000337995.4"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "NM_001329515.3",
"protein_id": "NP_001316444.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 704,
"cds_start": 42,
"cds_end": null,
"cds_length": 2115,
"cdna_start": 304,
"cdna_end": null,
"cdna_length": 2452,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001329515.3"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "ENST00000876809.1",
"protein_id": "ENSP00000546868.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 688,
"cds_start": 42,
"cds_end": null,
"cds_length": 2067,
"cdna_start": 499,
"cdna_end": null,
"cdna_length": 3785,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876809.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "ENST00000876810.1",
"protein_id": "ENSP00000546869.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 688,
"cds_start": 42,
"cds_end": null,
"cds_length": 2067,
"cdna_start": 317,
"cdna_end": null,
"cdna_length": 2989,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876810.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "ENST00000876811.1",
"protein_id": "ENSP00000546870.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 688,
"cds_start": 42,
"cds_end": null,
"cds_length": 2067,
"cdna_start": 571,
"cdna_end": null,
"cdna_length": 3298,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000876811.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "ENST00000960579.1",
"protein_id": "ENSP00000630638.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 688,
"cds_start": 42,
"cds_end": null,
"cds_length": 2067,
"cdna_start": 459,
"cdna_end": null,
"cdna_length": 3748,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960579.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "ENST00000960580.1",
"protein_id": "ENSP00000630639.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 688,
"cds_start": 42,
"cds_end": null,
"cds_length": 2067,
"cdna_start": 524,
"cdna_end": null,
"cdna_length": 3815,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000960580.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "NM_001329516.3",
"protein_id": "NP_001316445.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 648,
"cds_start": 42,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 260,
"cdna_end": null,
"cdna_length": 2301,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001329516.3"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "NM_001329522.3",
"protein_id": "NP_001316451.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 536,
"cds_start": 42,
"cds_end": null,
"cds_length": 1611,
"cdna_start": 304,
"cdna_end": null,
"cdna_length": 1948,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001329522.3"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "ENST00000304239.11",
"protein_id": "ENSP00000306102.7",
"transcript_support_level": 2,
"aa_start": 14,
"aa_end": null,
"aa_length": 536,
"cds_start": 42,
"cds_end": null,
"cds_length": 1611,
"cdna_start": 302,
"cdna_end": null,
"cdna_length": 1945,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000304239.11"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "ENST00000589245.5",
"protein_id": "ENSP00000467772.1",
"transcript_support_level": 4,
"aa_start": 14,
"aa_end": null,
"aa_length": 162,
"cds_start": 42,
"cds_end": null,
"cds_length": 490,
"cdna_start": 247,
"cdna_end": null,
"cdna_length": 695,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000589245.5"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "ENST00000587029.5",
"protein_id": "ENSP00000466057.1",
"transcript_support_level": 4,
"aa_start": 14,
"aa_end": null,
"aa_length": 87,
"cds_start": 42,
"cds_end": null,
"cds_length": 264,
"cdna_start": 390,
"cdna_end": null,
"cdna_length": 612,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000587029.5"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "XM_011526503.3",
"protein_id": "XP_011524805.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 688,
"cds_start": 42,
"cds_end": null,
"cds_length": 2067,
"cdna_start": 347,
"cdna_end": null,
"cdna_length": 3682,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011526503.3"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "XM_011526504.3",
"protein_id": "XP_011524806.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 688,
"cds_start": 42,
"cds_end": null,
"cds_length": 2067,
"cdna_start": 471,
"cdna_end": null,
"cdna_length": 3806,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011526504.3"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "XM_047438229.1",
"protein_id": "XP_047294185.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 688,
"cds_start": 42,
"cds_end": null,
"cds_length": 2067,
"cdna_start": 548,
"cdna_end": null,
"cdna_length": 3883,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047438229.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "XM_047438230.1",
"protein_id": "XP_047294186.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 688,
"cds_start": 42,
"cds_end": null,
"cds_length": 2067,
"cdna_start": 380,
"cdna_end": null,
"cdna_length": 3715,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047438230.1"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "XM_006723038.4",
"protein_id": "XP_006723101.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 648,
"cds_start": 42,
"cds_end": null,
"cds_length": 1947,
"cdna_start": 515,
"cdna_end": null,
"cdna_length": 2556,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_006723038.4"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "XM_011526511.3",
"protein_id": "XP_011524813.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 480,
"cds_start": 42,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 515,
"cdna_end": null,
"cdna_length": 2052,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_011526511.3"
},
{
"aa_ref": "D",
"aa_alt": "D",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.42C>T",
"hgvs_p": "p.Asp14Asp",
"transcript": "XM_047438232.1",
"protein_id": "XP_047294188.1",
"transcript_support_level": null,
"aa_start": 14,
"aa_end": null,
"aa_length": 480,
"cds_start": 42,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 471,
"cdna_end": null,
"cdna_length": 2008,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047438232.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.-257C>T",
"hgvs_p": null,
"transcript": "NM_001329517.1",
"protein_id": "NP_001316446.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 617,
"cds_start": null,
"cds_end": null,
"cds_length": 1854,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3934,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001329517.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF420",
"gene_hgnc_id": 20649,
"hgvs_c": "c.-257C>T",
"hgvs_p": null,
"transcript": "NM_001329519.1",
"protein_id": "NP_001316448.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 617,
"cds_start": null,
"cds_end": null,
"cds_length": 1854,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3890,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001329519.1"
},
{
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}
],
"message": null
}