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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 19-44175793-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=44175793&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "19",
"pos": 44175793,
"ref": "C",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "ENST00000337433.10",
"consequences": [
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "c.531C>T",
"hgvs_p": "p.Phe177Phe",
"transcript": "NM_001032373.2",
"protein_id": "NP_001027545.1",
"transcript_support_level": null,
"aa_start": 177,
"aa_end": null,
"aa_length": 803,
"cds_start": 531,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 671,
"cdna_end": null,
"cdna_length": 2563,
"mane_select": "ENST00000337433.10",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "c.531C>T",
"hgvs_p": "p.Phe177Phe",
"transcript": "ENST00000337433.10",
"protein_id": "ENSP00000336719.5",
"transcript_support_level": 1,
"aa_start": 177,
"aa_end": null,
"aa_length": 803,
"cds_start": 531,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 671,
"cdna_end": null,
"cdna_length": 2563,
"mane_select": "NM_001032373.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "c.531C>T",
"hgvs_p": "p.Phe177Phe",
"transcript": "ENST00000454662.6",
"protein_id": "ENSP00000393265.1",
"transcript_support_level": 1,
"aa_start": 177,
"aa_end": null,
"aa_length": 803,
"cds_start": 531,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 711,
"cdna_end": null,
"cdna_length": 2605,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "c.531C>T",
"hgvs_p": "p.Phe177Phe",
"transcript": "ENST00000590089.5",
"protein_id": "ENSP00000465121.1",
"transcript_support_level": 1,
"aa_start": 177,
"aa_end": null,
"aa_length": 803,
"cds_start": 531,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 898,
"cdna_end": null,
"cdna_length": 2788,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "c.*2806C>T",
"hgvs_p": null,
"transcript": "ENST00000588883.5",
"protein_id": "ENSP00000465401.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 89,
"cds_start": -4,
"cds_end": null,
"cds_length": 270,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5972,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "c.531C>T",
"hgvs_p": "p.Phe177Phe",
"transcript": "NM_001032372.2",
"protein_id": "NP_001027544.1",
"transcript_support_level": null,
"aa_start": 177,
"aa_end": null,
"aa_length": 803,
"cds_start": 531,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 775,
"cdna_end": null,
"cdna_length": 2667,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "c.531C>T",
"hgvs_p": "p.Phe177Phe",
"transcript": "NM_001319088.2",
"protein_id": "NP_001306017.1",
"transcript_support_level": null,
"aa_start": 177,
"aa_end": null,
"aa_length": 803,
"cds_start": 531,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 840,
"cdna_end": null,
"cdna_length": 2732,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "c.531C>T",
"hgvs_p": "p.Phe177Phe",
"transcript": "NM_001319089.2",
"protein_id": "NP_001306018.1",
"transcript_support_level": null,
"aa_start": 177,
"aa_end": null,
"aa_length": 803,
"cds_start": 531,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 697,
"cdna_end": null,
"cdna_length": 2589,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "c.531C>T",
"hgvs_p": "p.Phe177Phe",
"transcript": "NM_001319090.2",
"protein_id": "NP_001306019.1",
"transcript_support_level": null,
"aa_start": 177,
"aa_end": null,
"aa_length": 803,
"cds_start": 531,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 717,
"cdna_end": null,
"cdna_length": 2609,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "c.531C>T",
"hgvs_p": "p.Phe177Phe",
"transcript": "NM_001388168.1",
"protein_id": "NP_001375097.1",
"transcript_support_level": null,
"aa_start": 177,
"aa_end": null,
"aa_length": 803,
"cds_start": 531,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 713,
"cdna_end": null,
"cdna_length": 2605,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "c.531C>T",
"hgvs_p": "p.Phe177Phe",
"transcript": "NM_001388169.1",
"protein_id": "NP_001375098.1",
"transcript_support_level": null,
"aa_start": 177,
"aa_end": null,
"aa_length": 803,
"cds_start": 531,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 735,
"cdna_end": null,
"cdna_length": 2627,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "c.531C>T",
"hgvs_p": "p.Phe177Phe",
"transcript": "NM_001388170.1",
"protein_id": "NP_001375099.1",
"transcript_support_level": null,
"aa_start": 177,
"aa_end": null,
"aa_length": 803,
"cds_start": 531,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 849,
"cdna_end": null,
"cdna_length": 2741,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "c.531C>T",
"hgvs_p": "p.Phe177Phe",
"transcript": "NM_001388171.1",
"protein_id": "NP_001375100.1",
"transcript_support_level": null,
"aa_start": 177,
"aa_end": null,
"aa_length": 803,
"cds_start": 531,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 886,
"cdna_end": null,
"cdna_length": 2778,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "c.531C>T",
"hgvs_p": "p.Phe177Phe",
"transcript": "NM_001388172.1",
"protein_id": "NP_001375101.1",
"transcript_support_level": null,
"aa_start": 177,
"aa_end": null,
"aa_length": 803,
"cds_start": 531,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 895,
"cdna_end": null,
"cdna_length": 2787,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "c.531C>T",
"hgvs_p": "p.Phe177Phe",
"transcript": "NM_016444.3",
"protein_id": "NP_057528.2",
"transcript_support_level": null,
"aa_start": 177,
"aa_end": null,
"aa_length": 803,
"cds_start": 531,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 953,
"cdna_end": null,
"cdna_length": 2845,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "c.423C>T",
"hgvs_p": "p.Phe141Phe",
"transcript": "NM_001388178.1",
"protein_id": "NP_001375107.1",
"transcript_support_level": null,
"aa_start": 141,
"aa_end": null,
"aa_length": 767,
"cds_start": 423,
"cds_end": null,
"cds_length": 2304,
"cdna_start": 667,
"cdna_end": null,
"cdna_length": 2559,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "c.531C>T",
"hgvs_p": "p.Phe177Phe",
"transcript": "XM_006723367.4",
"protein_id": "XP_006723430.1",
"transcript_support_level": null,
"aa_start": 177,
"aa_end": null,
"aa_length": 803,
"cds_start": 531,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 875,
"cdna_end": null,
"cdna_length": 2767,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "c.531C>T",
"hgvs_p": "p.Phe177Phe",
"transcript": "XM_006723368.4",
"protein_id": "XP_006723431.1",
"transcript_support_level": null,
"aa_start": 177,
"aa_end": null,
"aa_length": 803,
"cds_start": 531,
"cds_end": null,
"cds_length": 2412,
"cdna_start": 761,
"cdna_end": null,
"cdna_length": 2653,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "F",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "c.531C>T",
"hgvs_p": "p.Phe177Phe",
"transcript": "XM_047439374.1",
"protein_id": "XP_047295330.1",
"transcript_support_level": null,
"aa_start": 177,
"aa_end": null,
"aa_length": 803,
"cds_start": 531,
"cds_end": null,
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"cdna_start": 1124,
"cdna_end": null,
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"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "n.671C>T",
"hgvs_p": null,
"transcript": "XR_002958356.2",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
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"cdna_length": 10563,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "n.671C>T",
"hgvs_p": null,
"transcript": "XR_002958357.2",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 10406,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "n.671C>T",
"hgvs_p": null,
"transcript": "XR_007066992.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 24214,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF226",
"gene_hgnc_id": 13019,
"hgvs_c": "n.671C>T",
"hgvs_p": null,
"transcript": "XR_007066994.1",
"protein_id": null,
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}
],
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}