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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 19-45815684-CC-GA (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=45815684&ref=CC&alt=GA&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "SYMPK",
          "hgnc_id": 22935,
          "hgvs_c": "c.3700_3701delGGinsTC",
          "hgvs_p": "p.Gly1234Ser",
          "inheritance_mode": "AD",
          "pathogenic_score": 0,
          "score": 0,
          "transcript": "NM_004819.3",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "",
      "acmg_score": 0,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "GA",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": null,
      "bayesdelnoaf_score": null,
      "chr": "19",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": null,
      "computational_score_selected": null,
      "computational_source_selected": null,
      "consequences": [
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1274,
          "aa_ref": "G",
          "aa_start": 1234,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4077,
          "cdna_start": 3803,
          "cds_end": null,
          "cds_length": 3825,
          "cds_start": 3700,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_004819.3",
          "gene_hgnc_id": 22935,
          "gene_symbol": "SYMPK",
          "hgvs_c": "c.3700_3701delGGinsTC",
          "hgvs_p": "p.Gly1234Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000245934.12",
          "protein_coding": true,
          "protein_id": "NP_004810.2",
          "strand": false,
          "transcript": "NM_004819.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1274,
          "aa_ref": "G",
          "aa_start": 1234,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 4077,
          "cdna_start": 3803,
          "cds_end": null,
          "cds_length": 3825,
          "cds_start": 3700,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000245934.12",
          "gene_hgnc_id": 22935,
          "gene_symbol": "SYMPK",
          "hgvs_c": "c.3700_3701delGGinsTC",
          "hgvs_p": "p.Gly1234Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_004819.3",
          "protein_coding": true,
          "protein_id": "ENSP00000245934.7",
          "strand": false,
          "transcript": "ENST00000245934.12",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1295,
          "aa_ref": "G",
          "aa_start": 1255,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4134,
          "cdna_start": 3873,
          "cds_end": null,
          "cds_length": 3888,
          "cds_start": 3763,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000876458.1",
          "gene_hgnc_id": 22935,
          "gene_symbol": "SYMPK",
          "hgvs_c": "c.3763_3764delGGinsTC",
          "hgvs_p": "p.Gly1255Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000546517.1",
          "strand": false,
          "transcript": "ENST00000876458.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1294,
          "aa_ref": "G",
          "aa_start": 1254,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4138,
          "cdna_start": 3877,
          "cds_end": null,
          "cds_length": 3885,
          "cds_start": 3760,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000876454.1",
          "gene_hgnc_id": 22935,
          "gene_symbol": "SYMPK",
          "hgvs_c": "c.3760_3761delGGinsTC",
          "hgvs_p": "p.Gly1254Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000546513.1",
          "strand": false,
          "transcript": "ENST00000876454.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1283,
          "aa_ref": "G",
          "aa_start": 1243,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4145,
          "cdna_start": 3884,
          "cds_end": null,
          "cds_length": 3852,
          "cds_start": 3727,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000876449.1",
          "gene_hgnc_id": 22935,
          "gene_symbol": "SYMPK",
          "hgvs_c": "c.3727_3728delGGinsTC",
          "hgvs_p": "p.Gly1243Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000546508.1",
          "strand": false,
          "transcript": "ENST00000876449.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1283,
          "aa_ref": "G",
          "aa_start": 1243,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4081,
          "cdna_start": 3820,
          "cds_end": null,
          "cds_length": 3852,
          "cds_start": 3727,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000876463.1",
          "gene_hgnc_id": 22935,
          "gene_symbol": "SYMPK",
          "hgvs_c": "c.3727_3728delGGinsTC",
          "hgvs_p": "p.Gly1243Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000546522.1",
          "strand": false,
          "transcript": "ENST00000876463.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1274,
          "aa_ref": "G",
          "aa_start": 1234,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4155,
          "cdna_start": 3881,
          "cds_end": null,
          "cds_length": 3825,
          "cds_start": 3700,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000715464.1",
          "gene_hgnc_id": 22935,
          "gene_symbol": "SYMPK",
          "hgvs_c": "c.3700_3701delGGinsTC",
          "hgvs_p": "p.Gly1234Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000520453.1",
          "strand": false,
          "transcript": "ENST00000715464.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1274,
          "aa_ref": "G",
          "aa_start": 1234,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4090,
          "cdna_start": 3858,
          "cds_end": null,
          "cds_length": 3825,
          "cds_start": 3700,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000876448.1",
          "gene_hgnc_id": 22935,
          "gene_symbol": "SYMPK",
          "hgvs_c": "c.3700_3701delGGinsTC",
          "hgvs_p": "p.Gly1234Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000546507.1",
          "strand": false,
          "transcript": "ENST00000876448.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1274,
          "aa_ref": "G",
          "aa_start": 1234,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4066,
          "cdna_start": 3805,
          "cds_end": null,
          "cds_length": 3825,
          "cds_start": 3700,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000876457.1",
          "gene_hgnc_id": 22935,
          "gene_symbol": "SYMPK",
          "hgvs_c": "c.3700_3701delGGinsTC",
          "hgvs_p": "p.Gly1234Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000546516.1",
          "strand": false,
          "transcript": "ENST00000876457.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1274,
          "aa_ref": "G",
          "aa_start": 1234,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4060,
          "cdna_start": 3799,
          "cds_end": null,
          "cds_length": 3825,
          "cds_start": 3700,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000876459.1",
          "gene_hgnc_id": 22935,
          "gene_symbol": "SYMPK",
          "hgvs_c": "c.3700_3701delGGinsTC",
          "hgvs_p": "p.Gly1234Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000546518.1",
          "strand": false,
          "transcript": "ENST00000876459.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1274,
          "aa_ref": "G",
          "aa_start": 1234,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4162,
          "cdna_start": 3901,
          "cds_end": null,
          "cds_length": 3825,
          "cds_start": 3700,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 28,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000876461.1",
          "gene_hgnc_id": 22935,
          "gene_symbol": "SYMPK",
          "hgvs_c": "c.3700_3701delGGinsTC",
          "hgvs_p": "p.Gly1234Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000546520.1",
          "strand": false,
          "transcript": "ENST00000876461.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1273,
          "aa_ref": "G",
          "aa_start": 1233,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4086,
          "cdna_start": 3825,
          "cds_end": null,
          "cds_length": 3822,
          "cds_start": 3697,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000876450.1",
          "gene_hgnc_id": 22935,
          "gene_symbol": "SYMPK",
          "hgvs_c": "c.3697_3698delGGinsTC",
          "hgvs_p": "p.Gly1233Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000546509.1",
          "strand": false,
          "transcript": "ENST00000876450.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1273,
          "aa_ref": "G",
          "aa_start": 1233,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4054,
          "cdna_start": 3793,
          "cds_end": null,
          "cds_length": 3822,
          "cds_start": 3697,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000876460.1",
          "gene_hgnc_id": 22935,
          "gene_symbol": "SYMPK",
          "hgvs_c": "c.3697_3698delGGinsTC",
          "hgvs_p": "p.Gly1233Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000546519.1",
          "strand": false,
          "transcript": "ENST00000876460.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1272,
          "aa_ref": "G",
          "aa_start": 1232,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4055,
          "cdna_start": 3794,
          "cds_end": null,
          "cds_length": 3819,
          "cds_start": 3694,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000876465.1",
          "gene_hgnc_id": 22935,
          "gene_symbol": "SYMPK",
          "hgvs_c": "c.3694_3695delGGinsTC",
          "hgvs_p": "p.Gly1232Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000546524.1",
          "strand": false,
          "transcript": "ENST00000876465.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1261,
          "aa_ref": "G",
          "aa_start": 1221,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4005,
          "cdna_start": 3764,
          "cds_end": null,
          "cds_length": 3786,
          "cds_start": 3661,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000876466.1",
          "gene_hgnc_id": 22935,
          "gene_symbol": "SYMPK",
          "hgvs_c": "c.3661_3662delGGinsTC",
          "hgvs_p": "p.Gly1221Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000546525.1",
          "strand": false,
          "transcript": "ENST00000876466.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1253,
          "aa_ref": "G",
          "aa_start": 1213,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 4019,
          "cdna_start": 3758,
          "cds_end": null,
          "cds_length": 3762,
          "cds_start": 3637,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 27,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000876453.1",
          "gene_hgnc_id": 22935,
          "gene_symbol": "SYMPK",
          "hgvs_c": "c.3637_3638delGGinsTC",
          "hgvs_p": "p.Gly1213Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000546512.1",
          "strand": false,
          "transcript": "ENST00000876453.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1221,
          "aa_ref": "G",
          "aa_start": 1181,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3917,
          "cdna_start": 3656,
          "cds_end": null,
          "cds_length": 3666,
          "cds_start": 3541,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000876455.1",
          "gene_hgnc_id": 22935,
          "gene_symbol": "SYMPK",
          "hgvs_c": "c.3541_3542delGGinsTC",
          "hgvs_p": "p.Gly1181Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000546514.1",
          "strand": false,
          "transcript": "ENST00000876455.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1215,
          "aa_ref": "G",
          "aa_start": 1175,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3887,
          "cdna_start": 3626,
          "cds_end": null,
          "cds_length": 3648,
          "cds_start": 3523,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000876464.1",
          "gene_hgnc_id": 22935,
          "gene_symbol": "SYMPK",
          "hgvs_c": "c.3523_3524delGGinsTC",
          "hgvs_p": "p.Gly1175Ser",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000546523.1",
          "strand": false,
          "transcript": "ENST00000876464.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "S",
          "aa_end": null,
          "aa_length": 1196,
          "aa_ref": "G",
          "aa_start": 1156,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3827,
          "cdna_start": 3566,
          "cds_end": null,
          "cds_length": 3591,
          "cds_start": 3466,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 26,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000916416.1",
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.