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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 19-49010016-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=49010016&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 11,
          "criteria": [
            "BP4_Moderate",
            "BP7",
            "BA1"
          ],
          "effects": [
            "synonymous_variant"
          ],
          "gene_symbol": "RUVBL2",
          "hgnc_id": 10475,
          "hgvs_c": "c.613C>T",
          "hgvs_p": "p.Leu205Leu",
          "inheritance_mode": "AD",
          "pathogenic_score": 0,
          "score": -11,
          "transcript": "NM_006666.3",
          "verdict": "Benign"
        },
        {
          "benign_score": 10,
          "criteria": [
            "BP4_Moderate",
            "BA1"
          ],
          "effects": [
            "downstream_gene_variant"
          ],
          "gene_symbol": "MIR6798",
          "hgnc_id": 50013,
          "hgvs_c": "n.*44C>T",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 0,
          "score": -10,
          "transcript": "NR_106856.1",
          "verdict": "Benign"
        }
      ],
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Moderate,BP7,BA1",
      "acmg_score": -11,
      "allele_count_reference_population": 752813,
      "alphamissense_prediction": null,
      "alphamissense_score": 0.1029,
      "alt": "T",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": "Benign",
      "bayesdelnoaf_score": -0.37,
      "chr": "19",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": "Benign",
      "computational_score_selected": -0.3700000047683716,
      "computational_source_selected": "BayesDel_noAF",
      "consequences": [
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 463,
          "aa_ref": "L",
          "aa_start": 205,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1545,
          "cdna_start": 638,
          "cds_end": null,
          "cds_length": 1392,
          "cds_start": 613,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 15,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "NM_006666.3",
          "gene_hgnc_id": 10475,
          "gene_symbol": "RUVBL2",
          "hgvs_c": "c.613C>T",
          "hgvs_p": "p.Leu205Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000595090.6",
          "protein_coding": true,
          "protein_id": "NP_006657.1",
          "strand": true,
          "transcript": "NM_006666.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 463,
          "aa_ref": "L",
          "aa_start": 205,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 1545,
          "cdna_start": 638,
          "cds_end": null,
          "cds_length": 1392,
          "cds_start": 613,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 15,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000595090.6",
          "gene_hgnc_id": 10475,
          "gene_symbol": "RUVBL2",
          "hgvs_c": "c.613C>T",
          "hgvs_p": "p.Leu205Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_006666.3",
          "protein_coding": true,
          "protein_id": "ENSP00000473172.1",
          "strand": true,
          "transcript": "ENST00000595090.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "nonsense_mediated_decay",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1478,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "non_coding_transcript_exon_variant"
          ],
          "exon_count": 15,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000221413.10",
          "gene_hgnc_id": 10475,
          "gene_symbol": "RUVBL2",
          "hgvs_c": "n.602C>T",
          "hgvs_p": null,
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": "ENSP00000221413.6",
          "strand": true,
          "transcript": "ENST00000221413.10",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 470,
          "aa_ref": "L",
          "aa_start": 212,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1509,
          "cdna_start": 647,
          "cds_end": null,
          "cds_length": 1413,
          "cds_start": 634,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 15,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000888169.1",
          "gene_hgnc_id": 10475,
          "gene_symbol": "RUVBL2",
          "hgvs_c": "c.634C>T",
          "hgvs_p": "p.Leu212Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000558228.1",
          "strand": true,
          "transcript": "ENST00000888169.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 462,
          "aa_ref": "L",
          "aa_start": 204,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1554,
          "cdna_start": 635,
          "cds_end": null,
          "cds_length": 1389,
          "cds_start": 610,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 15,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000888165.1",
          "gene_hgnc_id": 10475,
          "gene_symbol": "RUVBL2",
          "hgvs_c": "c.610C>T",
          "hgvs_p": "p.Leu204Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000558224.1",
          "strand": true,
          "transcript": "ENST00000888165.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 462,
          "aa_ref": "L",
          "aa_start": 205,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1507,
          "cdna_start": 647,
          "cds_end": null,
          "cds_length": 1389,
          "cds_start": 613,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 15,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000888166.1",
          "gene_hgnc_id": 10475,
          "gene_symbol": "RUVBL2",
          "hgvs_c": "c.613C>T",
          "hgvs_p": "p.Leu205Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000558225.1",
          "strand": true,
          "transcript": "ENST00000888166.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 461,
          "aa_ref": "L",
          "aa_start": 205,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1551,
          "cdna_start": 650,
          "cds_end": null,
          "cds_length": 1386,
          "cds_start": 613,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 15,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000940726.1",
          "gene_hgnc_id": 10475,
          "gene_symbol": "RUVBL2",
          "hgvs_c": "c.613C>T",
          "hgvs_p": "p.Leu205Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000610785.1",
          "strand": true,
          "transcript": "ENST00000940726.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 460,
          "aa_ref": "L",
          "aa_start": 202,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1495,
          "cdna_start": 632,
          "cds_end": null,
          "cds_length": 1383,
          "cds_start": 604,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 15,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000940727.1",
          "gene_hgnc_id": 10475,
          "gene_symbol": "RUVBL2",
          "hgvs_c": "c.604C>T",
          "hgvs_p": "p.Leu202Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000610786.1",
          "strand": true,
          "transcript": "ENST00000940727.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 458,
          "aa_ref": "L",
          "aa_start": 205,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1470,
          "cdna_start": 623,
          "cds_end": null,
          "cds_length": 1377,
          "cds_start": 613,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 15,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000888170.1",
          "gene_hgnc_id": 10475,
          "gene_symbol": "RUVBL2",
          "hgvs_c": "c.613C>T",
          "hgvs_p": "p.Leu205Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000558229.1",
          "strand": true,
          "transcript": "ENST00000888170.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 448,
          "aa_ref": "L",
          "aa_start": 205,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1453,
          "cdna_start": 636,
          "cds_end": null,
          "cds_length": 1347,
          "cds_start": 613,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 15,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000888168.1",
          "gene_hgnc_id": 10475,
          "gene_symbol": "RUVBL2",
          "hgvs_c": "c.613C>T",
          "hgvs_p": "p.Leu205Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000558227.1",
          "strand": true,
          "transcript": "ENST00000888168.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 429,
          "aa_ref": "L",
          "aa_start": 171,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1615,
          "cdna_start": 708,
          "cds_end": null,
          "cds_length": 1290,
          "cds_start": 511,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 15,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "NM_001321190.2",
          "gene_hgnc_id": 10475,
          "gene_symbol": "RUVBL2",
          "hgvs_c": "c.511C>T",
          "hgvs_p": "p.Leu171Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001308119.1",
          "strand": true,
          "transcript": "NM_001321190.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 418,
          "aa_ref": "L",
          "aa_start": 160,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1988,
          "cdna_start": 1056,
          "cds_end": null,
          "cds_length": 1257,
          "cds_start": 478,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 15,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "NM_001321191.1",
          "gene_hgnc_id": 10475,
          "gene_symbol": "RUVBL2",
          "hgvs_c": "c.478C>T",
          "hgvs_p": "p.Leu160Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001308120.1",
          "strand": true,
          "transcript": "NM_001321191.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 405,
          "aa_ref": "L",
          "aa_start": 147,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1330,
          "cdna_start": 467,
          "cds_end": null,
          "cds_length": 1218,
          "cds_start": 439,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 13,
          "exon_rank": 6,
          "exon_rank_end": null,
          "feature": "ENST00000888167.1",
          "gene_hgnc_id": 10475,
          "gene_symbol": "RUVBL2",
          "hgvs_c": "c.439C>T",
          "hgvs_p": "p.Leu147Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000558226.1",
          "strand": true,
          "transcript": "ENST00000888167.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 354,
          "aa_ref": "L",
          "aa_start": 160,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1641,
          "cdna_start": 942,
          "cds_end": null,
          "cds_length": 1065,
          "cds_start": 478,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 14,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000601968.5",
          "gene_hgnc_id": 10475,
          "gene_symbol": "RUVBL2",
          "hgvs_c": "c.478C>T",
          "hgvs_p": "p.Leu160Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000471524.1",
          "strand": true,
          "transcript": "ENST00000601968.5",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 354,
          "aa_ref": "L",
          "aa_start": 160,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1065,
          "cdna_start": 478,
          "cds_end": null,
          "cds_length": 1065,
          "cds_start": 478,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 10,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000627972.1",
          "gene_hgnc_id": 10475,
          "gene_symbol": "RUVBL2",
          "hgvs_c": "c.478C>T",
          "hgvs_p": "p.Leu160Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000486242.1",
          "strand": true,
          "transcript": "ENST00000627972.1",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 350,
          "aa_ref": "L",
          "aa_start": 92,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 1148,
          "cdna_start": 281,
          "cds_end": null,
          "cds_length": 1053,
          "cds_start": 274,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 12,
          "exon_rank": 5,
          "exon_rank_end": null,
          "feature": "ENST00000940729.1",
          "gene_hgnc_id": 10475,
          "gene_symbol": "RUVBL2",
          "hgvs_c": "c.274C>T",
          "hgvs_p": "p.Leu92Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000610788.1",
          "strand": true,
          "transcript": "ENST00000940729.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 278,
          "aa_ref": "L",
          "aa_start": 205,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 937,
          "cdna_start": 632,
          "cds_end": null,
          "cds_length": 837,
          "cds_start": 613,
          "consequences": [
            "synonymous_variant"
          ],
          "exon_count": 11,
          "exon_rank": 8,
          "exon_rank_end": null,
          "feature": "ENST00000940728.1",
          "gene_hgnc_id": 10475,
          "gene_symbol": "RUVBL2",
          "hgvs_c": "c.613C>T",
          "hgvs_p": "p.Leu205Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000610787.1",
          "strand": true,
          "transcript": "ENST00000940728.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": 221,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 835,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": 666,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 8,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000940725.1",
          "gene_hgnc_id": 10475,
          "gene_symbol": "RUVBL2",
          "hgvs_c": "c.395+2869C>T",
          "hgvs_p": null,
          "intron_rank": 5,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000610784.1",
          "strand": true,
          "transcript": "ENST00000940725.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "retained_intron",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 959,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.