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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 19-49556714-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=49556714&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "19",
"pos": 49556714,
"ref": "A",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_001363649.3",
"consequences": [
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.560T>C",
"hgvs_p": "p.Met187Thr",
"transcript": "NM_001270960.2",
"protein_id": "NP_001257889.1",
"transcript_support_level": null,
"aa_start": 187,
"aa_end": null,
"aa_length": 301,
"cds_start": 560,
"cds_end": null,
"cds_length": 906,
"cdna_start": 603,
"cdna_end": null,
"cdna_length": 1232,
"mane_select": "ENST00000596358.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001270960.2"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.560T>C",
"hgvs_p": "p.Met187Thr",
"transcript": "ENST00000596358.6",
"protein_id": "ENSP00000470034.1",
"transcript_support_level": 1,
"aa_start": 187,
"aa_end": null,
"aa_length": 301,
"cds_start": 560,
"cds_end": null,
"cds_length": 906,
"cdna_start": 603,
"cdna_end": null,
"cdna_length": 1232,
"mane_select": "NM_001270960.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000596358.6"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.560T>C",
"hgvs_p": "p.Met187Thr",
"transcript": "ENST00000874168.1",
"protein_id": "ENSP00000544227.1",
"transcript_support_level": null,
"aa_start": 187,
"aa_end": null,
"aa_length": 310,
"cds_start": 560,
"cds_end": null,
"cds_length": 933,
"cdna_start": 617,
"cdna_end": null,
"cdna_length": 1028,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000874168.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.569T>C",
"hgvs_p": "p.Met190Thr",
"transcript": "NM_001363649.3",
"protein_id": "NP_001350578.1",
"transcript_support_level": null,
"aa_start": 190,
"aa_end": null,
"aa_length": 304,
"cds_start": 569,
"cds_end": null,
"cds_length": 915,
"cdna_start": 731,
"cdna_end": null,
"cdna_length": 1117,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001363649.3"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.569T>C",
"hgvs_p": "p.Met190Thr",
"transcript": "NM_001439222.1",
"protein_id": "NP_001426151.1",
"transcript_support_level": null,
"aa_start": 190,
"aa_end": null,
"aa_length": 304,
"cds_start": 569,
"cds_end": null,
"cds_length": 915,
"cdna_start": 612,
"cdna_end": null,
"cdna_length": 998,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439222.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.569T>C",
"hgvs_p": "p.Met190Thr",
"transcript": "NM_001439223.1",
"protein_id": "NP_001426152.1",
"transcript_support_level": null,
"aa_start": 190,
"aa_end": null,
"aa_length": 304,
"cds_start": 569,
"cds_end": null,
"cds_length": 915,
"cdna_start": 1986,
"cdna_end": null,
"cdna_length": 2372,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439223.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.569T>C",
"hgvs_p": "p.Met190Thr",
"transcript": "ENST00000339093.7",
"protein_id": "ENSP00000343497.3",
"transcript_support_level": 5,
"aa_start": 190,
"aa_end": null,
"aa_length": 304,
"cds_start": 569,
"cds_end": null,
"cds_length": 915,
"cdna_start": 614,
"cdna_end": null,
"cdna_length": 1000,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000339093.7"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.569T>C",
"hgvs_p": "p.Met190Thr",
"transcript": "ENST00000874162.1",
"protein_id": "ENSP00000544221.1",
"transcript_support_level": null,
"aa_start": 190,
"aa_end": null,
"aa_length": 304,
"cds_start": 569,
"cds_end": null,
"cds_length": 915,
"cdna_start": 851,
"cdna_end": null,
"cdna_length": 1234,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000874162.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.569T>C",
"hgvs_p": "p.Met190Thr",
"transcript": "ENST00000874167.1",
"protein_id": "ENSP00000544226.1",
"transcript_support_level": null,
"aa_start": 190,
"aa_end": null,
"aa_length": 304,
"cds_start": 569,
"cds_end": null,
"cds_length": 915,
"cdna_start": 752,
"cdna_end": null,
"cdna_length": 1136,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000874167.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.569T>C",
"hgvs_p": "p.Met190Thr",
"transcript": "ENST00000874171.1",
"protein_id": "ENSP00000544230.1",
"transcript_support_level": null,
"aa_start": 190,
"aa_end": null,
"aa_length": 304,
"cds_start": 569,
"cds_end": null,
"cds_length": 915,
"cdna_start": 745,
"cdna_end": null,
"cdna_length": 1129,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000874171.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.569T>C",
"hgvs_p": "p.Met190Thr",
"transcript": "ENST00000874172.1",
"protein_id": "ENSP00000544231.1",
"transcript_support_level": null,
"aa_start": 190,
"aa_end": null,
"aa_length": 304,
"cds_start": 569,
"cds_end": null,
"cds_length": 915,
"cdna_start": 710,
"cdna_end": null,
"cdna_length": 1094,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000874172.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.569T>C",
"hgvs_p": "p.Met190Thr",
"transcript": "ENST00000917074.1",
"protein_id": "ENSP00000587133.1",
"transcript_support_level": null,
"aa_start": 190,
"aa_end": null,
"aa_length": 304,
"cds_start": 569,
"cds_end": null,
"cds_length": 915,
"cdna_start": 657,
"cdna_end": null,
"cdna_length": 1043,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000917074.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.569T>C",
"hgvs_p": "p.Met190Thr",
"transcript": "ENST00000917075.1",
"protein_id": "ENSP00000587134.1",
"transcript_support_level": null,
"aa_start": 190,
"aa_end": null,
"aa_length": 304,
"cds_start": 569,
"cds_end": null,
"cds_length": 915,
"cdna_start": 637,
"cdna_end": null,
"cdna_length": 1023,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000917075.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.569T>C",
"hgvs_p": "p.Met190Thr",
"transcript": "ENST00000917076.1",
"protein_id": "ENSP00000587135.1",
"transcript_support_level": null,
"aa_start": 190,
"aa_end": null,
"aa_length": 304,
"cds_start": 569,
"cds_end": null,
"cds_length": 915,
"cdna_start": 750,
"cdna_end": null,
"cdna_length": 1136,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000917076.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.569T>C",
"hgvs_p": "p.Met190Thr",
"transcript": "ENST00000917077.1",
"protein_id": "ENSP00000587136.1",
"transcript_support_level": null,
"aa_start": 190,
"aa_end": null,
"aa_length": 304,
"cds_start": 569,
"cds_end": null,
"cds_length": 915,
"cdna_start": 862,
"cdna_end": null,
"cdna_length": 1248,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000917077.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.560T>C",
"hgvs_p": "p.Met187Thr",
"transcript": "NM_001439224.1",
"protein_id": "NP_001426153.1",
"transcript_support_level": null,
"aa_start": 187,
"aa_end": null,
"aa_length": 301,
"cds_start": 560,
"cds_end": null,
"cds_length": 906,
"cdna_start": 1977,
"cdna_end": null,
"cdna_length": 2363,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001439224.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.560T>C",
"hgvs_p": "p.Met187Thr",
"transcript": "NM_015953.6",
"protein_id": "NP_057037.1",
"transcript_support_level": null,
"aa_start": 187,
"aa_end": null,
"aa_length": 301,
"cds_start": 560,
"cds_end": null,
"cds_length": 906,
"cdna_start": 722,
"cdna_end": null,
"cdna_length": 1108,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015953.6"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.560T>C",
"hgvs_p": "p.Met187Thr",
"transcript": "ENST00000874163.1",
"protein_id": "ENSP00000544222.1",
"transcript_support_level": null,
"aa_start": 187,
"aa_end": null,
"aa_length": 301,
"cds_start": 560,
"cds_end": null,
"cds_length": 906,
"cdna_start": 652,
"cdna_end": null,
"cdna_length": 1038,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000874163.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.560T>C",
"hgvs_p": "p.Met187Thr",
"transcript": "ENST00000874164.1",
"protein_id": "ENSP00000544223.1",
"transcript_support_level": null,
"aa_start": 187,
"aa_end": null,
"aa_length": 301,
"cds_start": 560,
"cds_end": null,
"cds_length": 906,
"cdna_start": 758,
"cdna_end": null,
"cdna_length": 1144,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000874164.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.560T>C",
"hgvs_p": "p.Met187Thr",
"transcript": "ENST00000874165.1",
"protein_id": "ENSP00000544224.1",
"transcript_support_level": null,
"aa_start": 187,
"aa_end": null,
"aa_length": 301,
"cds_start": 560,
"cds_end": null,
"cds_length": 906,
"cdna_start": 743,
"cdna_end": null,
"cdna_length": 1131,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000874165.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.560T>C",
"hgvs_p": "p.Met187Thr",
"transcript": "ENST00000874166.1",
"protein_id": "ENSP00000544225.1",
"transcript_support_level": null,
"aa_start": 187,
"aa_end": null,
"aa_length": 301,
"cds_start": 560,
"cds_end": null,
"cds_length": 906,
"cdna_start": 758,
"cdna_end": null,
"cdna_length": 1144,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000874166.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NOSIP",
"gene_hgnc_id": 17946,
"hgvs_c": "c.560T>C",
"hgvs_p": "p.Met187Thr",
"transcript": "ENST00000874169.1",
"protein_id": "ENSP00000544228.1",
"transcript_support_level": null,
"aa_start": 187,
"aa_end": null,
"aa_length": 301,
"cds_start": 560,
"cds_end": null,
"cds_length": 906,
"cdna_start": 730,
"cdna_end": null,
"cdna_length": 1116,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000874169.1"
},
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}
],
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}