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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 19-49908421-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=49908421&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "19",
      "pos": 49908421,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "NM_012346.5",
      "consequences": [
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP62",
          "gene_hgnc_id": 8066,
          "hgvs_c": "c.1387G>A",
          "hgvs_p": "p.Ala463Thr",
          "transcript": "NM_016553.5",
          "protein_id": "NP_057637.2",
          "transcript_support_level": null,
          "aa_start": 463,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 1387,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000352066.8",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_016553.5"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP62",
          "gene_hgnc_id": 8066,
          "hgvs_c": "c.1387G>A",
          "hgvs_p": "p.Ala463Thr",
          "transcript": "ENST00000352066.8",
          "protein_id": "ENSP00000305503.3",
          "transcript_support_level": 1,
          "aa_start": 463,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 1387,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_016553.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000352066.8"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP62",
          "gene_hgnc_id": 8066,
          "hgvs_c": "c.1387G>A",
          "hgvs_p": "p.Ala463Thr",
          "transcript": "ENST00000422090.2",
          "protein_id": "ENSP00000407331.1",
          "transcript_support_level": 1,
          "aa_start": 463,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 1387,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000422090.2"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP62",
          "gene_hgnc_id": 8066,
          "hgvs_c": "c.1387G>A",
          "hgvs_p": "p.Ala463Thr",
          "transcript": "ENST00000597029.6",
          "protein_id": "ENSP00000473192.1",
          "transcript_support_level": 1,
          "aa_start": 463,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 1387,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000597029.6"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP62",
          "gene_hgnc_id": 8066,
          "hgvs_c": "c.1159G>A",
          "hgvs_p": "p.Ala387Thr",
          "transcript": "ENST00000597723.5",
          "protein_id": "ENSP00000469283.1",
          "transcript_support_level": 1,
          "aa_start": 387,
          "aa_end": null,
          "aa_length": 446,
          "cds_start": 1159,
          "cds_end": null,
          "cds_length": 1341,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000597723.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "IL4I1",
          "gene_hgnc_id": 19094,
          "hgvs_c": "c.-227-4100G>A",
          "hgvs_p": null,
          "transcript": "ENST00000341114.7",
          "protein_id": "ENSP00000342557.2",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 589,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1770,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000341114.7"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "IL4I1",
          "gene_hgnc_id": 19094,
          "hgvs_c": "c.-285-4100G>A",
          "hgvs_p": null,
          "transcript": "ENST00000595948.5",
          "protein_id": "ENSP00000472474.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 589,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1770,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000595948.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 11,
          "intron_rank": 2,
          "intron_rank_end": null,
          "gene_symbol": "IL4I1",
          "gene_hgnc_id": 19094,
          "hgvs_c": "n.-227-4100G>A",
          "hgvs_p": null,
          "transcript": "ENST00000601717.5",
          "protein_id": "ENSP00000469467.1",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000601717.5"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP62",
          "gene_hgnc_id": 8066,
          "hgvs_c": "c.1387G>A",
          "hgvs_p": "p.Ala463Thr",
          "transcript": "NM_001193357.2",
          "protein_id": "NP_001180286.1",
          "transcript_support_level": null,
          "aa_start": 463,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 1387,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001193357.2"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP62",
          "gene_hgnc_id": 8066,
          "hgvs_c": "c.1387G>A",
          "hgvs_p": "p.Ala463Thr",
          "transcript": "NM_012346.5",
          "protein_id": "NP_036478.2",
          "transcript_support_level": null,
          "aa_start": 463,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 1387,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_012346.5"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP62",
          "gene_hgnc_id": 8066,
          "hgvs_c": "c.1387G>A",
          "hgvs_p": "p.Ala463Thr",
          "transcript": "NM_153718.4",
          "protein_id": "NP_714940.1",
          "transcript_support_level": null,
          "aa_start": 463,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 1387,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_153718.4"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP62",
          "gene_hgnc_id": 8066,
          "hgvs_c": "c.1387G>A",
          "hgvs_p": "p.Ala463Thr",
          "transcript": "NM_153719.4",
          "protein_id": "NP_714941.1",
          "transcript_support_level": null,
          "aa_start": 463,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 1387,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_153719.4"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP62",
          "gene_hgnc_id": 8066,
          "hgvs_c": "c.1387G>A",
          "hgvs_p": "p.Ala463Thr",
          "transcript": "ENST00000596217.1",
          "protein_id": "ENSP00000471191.1",
          "transcript_support_level": 2,
          "aa_start": 463,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 1387,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000596217.1"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP62",
          "gene_hgnc_id": 8066,
          "hgvs_c": "c.1387G>A",
          "hgvs_p": "p.Ala463Thr",
          "transcript": "ENST00000596437.6",
          "protein_id": "ENSP00000468842.2",
          "transcript_support_level": 4,
          "aa_start": 463,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 1387,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000596437.6"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP62",
          "gene_hgnc_id": 8066,
          "hgvs_c": "c.1387G>A",
          "hgvs_p": "p.Ala463Thr",
          "transcript": "ENST00000598301.2",
          "protein_id": "ENSP00000515009.1",
          "transcript_support_level": 4,
          "aa_start": 463,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 1387,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000598301.2"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP62",
          "gene_hgnc_id": 8066,
          "hgvs_c": "c.1387G>A",
          "hgvs_p": "p.Ala463Thr",
          "transcript": "ENST00000599560.6",
          "protein_id": "ENSP00000515013.1",
          "transcript_support_level": 2,
          "aa_start": 463,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 1387,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000599560.6"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP62",
          "gene_hgnc_id": 8066,
          "hgvs_c": "c.1387G>A",
          "hgvs_p": "p.Ala463Thr",
          "transcript": "ENST00000599788.2",
          "protein_id": "ENSP00000468884.2",
          "transcript_support_level": 4,
          "aa_start": 463,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 1387,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000599788.2"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 4,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP62",
          "gene_hgnc_id": 8066,
          "hgvs_c": "c.1387G>A",
          "hgvs_p": "p.Ala463Thr",
          "transcript": "ENST00000600583.6",
          "protein_id": "ENSP00000515011.1",
          "transcript_support_level": 4,
          "aa_start": 463,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 1387,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000600583.6"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 3,
          "exon_rank_end": null,
          "exon_count": 3,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP62",
          "gene_hgnc_id": 8066,
          "hgvs_c": "c.1387G>A",
          "hgvs_p": "p.Ala463Thr",
          "transcript": "ENST00000600935.2",
          "protein_id": "ENSP00000468839.2",
          "transcript_support_level": 4,
          "aa_start": 463,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 1387,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000600935.2"
        },
        {
          "aa_ref": "A",
          "aa_alt": "T",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 2,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "NUP62",
          "gene_hgnc_id": 8066,
          "hgvs_c": "c.1387G>A",
          "hgvs_p": "p.Ala463Thr",
          "transcript": "ENST00000700473.1",
          "protein_id": "ENSP00000515006.1",
          "transcript_support_level": null,
          "aa_start": 463,
          "aa_end": null,
          "aa_length": 522,
          "cds_start": 1387,
          "cds_end": null,
          "cds_length": 1569,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
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      "gnomad_exomes_af": 6.84121e-7,
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      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
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      "revel_prediction": "Benign",
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            "BP4_Moderate"
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          "verdict": "Uncertain_significance",
          "transcript": "NM_012346.5",
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          "score": 0,
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            "BP4_Moderate"
          ],
          "verdict": "Uncertain_significance",
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          "effects": [
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      "clinvar_disease": "not provided",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not provided",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
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  ],
  "message": null
}