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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 19-5022593-T-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=5022593&ref=T&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "19",
"pos": 5022593,
"ref": "T",
"alt": "A",
"effect": "intron_variant",
"transcript": "NM_001411148.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-26+6254T>A",
"hgvs_p": null,
"transcript": "NM_015015.3",
"protein_id": "NP_055830.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1096,
"cds_start": null,
"cds_end": null,
"cds_length": 3291,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000159111.9",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015015.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-26+6254T>A",
"hgvs_p": null,
"transcript": "ENST00000159111.9",
"protein_id": "ENSP00000159111.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1096,
"cds_start": null,
"cds_end": null,
"cds_length": 3291,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_015015.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000159111.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-26+6254T>A",
"hgvs_p": null,
"transcript": "ENST00000536461.6",
"protein_id": "ENSP00000440495.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1130,
"cds_start": null,
"cds_end": null,
"cds_length": 3393,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000536461.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-26+6254T>A",
"hgvs_p": null,
"transcript": "ENST00000381759.8",
"protein_id": "ENSP00000371178.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 448,
"cds_start": null,
"cds_end": null,
"cds_length": 1347,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000381759.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-26+6254T>A",
"hgvs_p": null,
"transcript": "NM_001411148.1",
"protein_id": "NP_001398077.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1130,
"cds_start": null,
"cds_end": null,
"cds_length": 3393,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001411148.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-26+6254T>A",
"hgvs_p": null,
"transcript": "ENST00000611640.4",
"protein_id": "ENSP00000480642.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1130,
"cds_start": null,
"cds_end": null,
"cds_length": 3393,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000611640.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-26+6254T>A",
"hgvs_p": null,
"transcript": "ENST00000938256.1",
"protein_id": "ENSP00000608315.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1127,
"cds_start": null,
"cds_end": null,
"cds_length": 3384,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938256.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-26+6254T>A",
"hgvs_p": null,
"transcript": "ENST00000879848.1",
"protein_id": "ENSP00000549907.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1110,
"cds_start": null,
"cds_end": null,
"cds_length": 3333,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000879848.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-26+6254T>A",
"hgvs_p": null,
"transcript": "ENST00000938254.1",
"protein_id": "ENSP00000608313.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1105,
"cds_start": null,
"cds_end": null,
"cds_length": 3318,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938254.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-26+6254T>A",
"hgvs_p": null,
"transcript": "ENST00000879850.1",
"protein_id": "ENSP00000549909.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1101,
"cds_start": null,
"cds_end": null,
"cds_length": 3306,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000879850.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-26+6254T>A",
"hgvs_p": null,
"transcript": "ENST00000938252.1",
"protein_id": "ENSP00000608311.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1099,
"cds_start": null,
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"cds_length": 3300,
"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938252.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-26+6254T>A",
"hgvs_p": null,
"transcript": "ENST00000938255.1",
"protein_id": "ENSP00000608314.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1096,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000938255.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-331+6254T>A",
"hgvs_p": null,
"transcript": "ENST00000959319.1",
"protein_id": "ENSP00000629378.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 1096,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000959319.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 23,
"intron_rank": 2,
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"gene_symbol": "KDM4B",
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"hgvs_c": "c.-26+6254T>A",
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"transcript": "ENST00000959320.1",
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"biotype": "protein_coding",
"feature": "ENST00000959320.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-26+6254T>A",
"hgvs_p": null,
"transcript": "ENST00000879849.1",
"protein_id": "ENSP00000549908.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000879849.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 22,
"intron_rank": 2,
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"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-26+6254T>A",
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"transcript": "ENST00000938251.1",
"protein_id": "ENSP00000608310.1",
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"biotype": "protein_coding",
"feature": "ENST00000938251.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-26+6254T>A",
"hgvs_p": null,
"transcript": "ENST00000938253.1",
"protein_id": "ENSP00000608312.1",
"transcript_support_level": null,
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"cdna_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000938253.1"
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-26+6254T>A",
"hgvs_p": null,
"transcript": "ENST00000959318.1",
"protein_id": "ENSP00000629377.1",
"transcript_support_level": null,
"aa_start": null,
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"mane_select": null,
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"biotype": "protein_coding",
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},
{
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"strand": true,
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"intron_variant"
],
"exon_rank": null,
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"exon_count": 21,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
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"hgvs_c": "c.-26+6254T>A",
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"feature": "ENST00000879851.1"
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
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"exon_count": 21,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-26+6254T>A",
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"transcript": "ENST00000959317.1",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
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"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-26+6254T>A",
"hgvs_p": null,
"transcript": "ENST00000959316.1",
"protein_id": "ENSP00000629375.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 968,
"cds_start": null,
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"cdna_start": null,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000959316.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "KDM4B",
"gene_hgnc_id": 29136,
"hgvs_c": "c.-26+6254T>A",
"hgvs_p": null,
"transcript": "NM_001370093.1",
"protein_id": "NP_001357022.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": 448,
"cds_start": null,
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"cdna_start": null,
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"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001370093.1"
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
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