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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 19-50379010-C-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=50379010&ref=C&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "19",
"pos": 50379010,
"ref": "C",
"alt": "G",
"effect": "synonymous_variant",
"transcript": "NM_007121.7",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "NM_007121.7",
"protein_id": "NP_009052.4",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 460,
"cds_start": 756,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000253727.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_007121.7"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000253727.10",
"protein_id": "ENSP00000253727.4",
"transcript_support_level": 1,
"aa_start": 252,
"aa_end": null,
"aa_length": 460,
"cds_start": 756,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_007121.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000253727.10"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.465C>G",
"hgvs_p": "p.Pro155Pro",
"transcript": "ENST00000411902.6",
"protein_id": "ENSP00000396151.2",
"transcript_support_level": 1,
"aa_start": 155,
"aa_end": null,
"aa_length": 363,
"cds_start": 465,
"cds_end": null,
"cds_length": 1092,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000411902.6"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000967772.1",
"protein_id": "ENSP00000637831.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 489,
"cds_start": 756,
"cds_end": null,
"cds_length": 1470,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000967772.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000593926.5",
"protein_id": "ENSP00000471194.1",
"transcript_support_level": 5,
"aa_start": 252,
"aa_end": null,
"aa_length": 460,
"cds_start": 756,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000593926.5"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000652203.1",
"protein_id": "ENSP00000499121.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 460,
"cds_start": 756,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000652203.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000852422.1",
"protein_id": "ENSP00000522481.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 460,
"cds_start": 756,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000852422.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000852425.1",
"protein_id": "ENSP00000522484.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 460,
"cds_start": 756,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000852425.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000939061.1",
"protein_id": "ENSP00000609120.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 460,
"cds_start": 756,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939061.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000939062.1",
"protein_id": "ENSP00000609121.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 460,
"cds_start": 756,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939062.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000939063.1",
"protein_id": "ENSP00000609122.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 460,
"cds_start": 756,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939063.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000939066.1",
"protein_id": "ENSP00000609125.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 460,
"cds_start": 756,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939066.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000939069.1",
"protein_id": "ENSP00000609128.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 460,
"cds_start": 756,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939069.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000939070.1",
"protein_id": "ENSP00000609129.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 460,
"cds_start": 756,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939070.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000939071.1",
"protein_id": "ENSP00000609130.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 460,
"cds_start": 756,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939071.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000939072.1",
"protein_id": "ENSP00000609131.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 460,
"cds_start": 756,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939072.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000939073.1",
"protein_id": "ENSP00000609132.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 460,
"cds_start": 756,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000939073.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000967767.1",
"protein_id": "ENSP00000637826.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 460,
"cds_start": 756,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000967767.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000967768.1",
"protein_id": "ENSP00000637827.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 460,
"cds_start": 756,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000967768.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000967769.1",
"protein_id": "ENSP00000637828.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 460,
"cds_start": 756,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000967769.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000967770.1",
"protein_id": "ENSP00000637829.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 460,
"cds_start": 756,
"cds_end": null,
"cds_length": 1383,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000967770.1"
},
{
"aa_ref": "P",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NR1H2",
"gene_hgnc_id": 7965,
"hgvs_c": "c.756C>G",
"hgvs_p": "p.Pro252Pro",
"transcript": "ENST00000939065.1",
"protein_id": "ENSP00000609124.1",
"transcript_support_level": null,
"aa_start": 252,
"aa_end": null,
"aa_length": 458,
"cds_start": 756,
"cds_end": null,
"cds_length": 1377,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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