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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 19-51965037-TGA-GGG (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=51965037&ref=TGA&alt=GGG&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "ZNF350",
          "hgnc_id": 16656,
          "hgvs_c": "c.1414_1416delTCAinsCCC",
          "hgvs_p": "p.Ser472Pro",
          "inheritance_mode": "AR",
          "pathogenic_score": 0,
          "score": 0,
          "transcript": "NM_021632.4",
          "verdict": "Uncertain_significance"
        },
        {
          "benign_score": 0,
          "criteria": [],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "ZNF350-AS1",
          "hgnc_id": 48598,
          "hgvs_c": "n.125-11354_125-11352delTGAinsGGG",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 0,
          "score": 0,
          "transcript": "ENST00000595010.5",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "",
      "acmg_score": 0,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "GGG",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": null,
      "bayesdelnoaf_score": null,
      "chr": "19",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": null,
      "computational_score_selected": null,
      "computational_source_selected": null,
      "consequences": [
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 532,
          "aa_ref": "S",
          "aa_start": 472,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2355,
          "cdna_start": 1658,
          "cds_end": null,
          "cds_length": 1599,
          "cds_start": 1414,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_021632.4",
          "gene_hgnc_id": 16656,
          "gene_symbol": "ZNF350",
          "hgvs_c": "c.1414_1416delTCAinsCCC",
          "hgvs_p": "p.Ser472Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000243644.9",
          "protein_coding": true,
          "protein_id": "NP_067645.3",
          "strand": false,
          "transcript": "NM_021632.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 532,
          "aa_ref": "S",
          "aa_start": 472,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 2355,
          "cdna_start": 1658,
          "cds_end": null,
          "cds_length": 1599,
          "cds_start": 1414,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000243644.9",
          "gene_hgnc_id": 16656,
          "gene_symbol": "ZNF350",
          "hgvs_c": "c.1414_1416delTCAinsCCC",
          "hgvs_p": "p.Ser472Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_021632.4",
          "protein_coding": true,
          "protein_id": "ENSP00000243644.3",
          "strand": false,
          "transcript": "ENST00000243644.9",
          "transcript_support_level": 1
        },
        {
          "aa_alt": null,
          "aa_end": null,
          "aa_length": null,
          "aa_ref": null,
          "aa_start": null,
          "biotype": "pseudogene",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 755,
          "cdna_start": null,
          "cds_end": null,
          "cds_length": null,
          "cds_start": null,
          "consequences": [
            "intron_variant"
          ],
          "exon_count": 3,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000595010.5",
          "gene_hgnc_id": 48598,
          "gene_symbol": "ZNF350-AS1",
          "hgvs_c": "n.125-11354_125-11352delTGAinsGGG",
          "hgvs_p": null,
          "intron_rank": 1,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": false,
          "protein_id": null,
          "strand": true,
          "transcript": "ENST00000595010.5",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 555,
          "aa_ref": "S",
          "aa_start": 495,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2432,
          "cdna_start": 1735,
          "cds_end": null,
          "cds_length": 1668,
          "cds_start": 1483,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 6,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000853589.1",
          "gene_hgnc_id": 16656,
          "gene_symbol": "ZNF350",
          "hgvs_c": "c.1483_1485delTCAinsCCC",
          "hgvs_p": "p.Ser495Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000523648.1",
          "strand": false,
          "transcript": "ENST00000853589.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 532,
          "aa_ref": "S",
          "aa_start": 472,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2615,
          "cdna_start": 1920,
          "cds_end": null,
          "cds_length": 1599,
          "cds_start": 1414,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 6,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000853590.1",
          "gene_hgnc_id": 16656,
          "gene_symbol": "ZNF350",
          "hgvs_c": "c.1414_1416delTCAinsCCC",
          "hgvs_p": "p.Ser472Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000523649.1",
          "strand": false,
          "transcript": "ENST00000853590.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 532,
          "aa_ref": "S",
          "aa_start": 472,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2411,
          "cdna_start": 1721,
          "cds_end": null,
          "cds_length": 1599,
          "cds_start": 1414,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 6,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000853591.1",
          "gene_hgnc_id": 16656,
          "gene_symbol": "ZNF350",
          "hgvs_c": "c.1414_1416delTCAinsCCC",
          "hgvs_p": "p.Ser472Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000523650.1",
          "strand": false,
          "transcript": "ENST00000853591.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 532,
          "aa_ref": "S",
          "aa_start": 472,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2430,
          "cdna_start": 1740,
          "cds_end": null,
          "cds_length": 1599,
          "cds_start": 1414,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 6,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000853592.1",
          "gene_hgnc_id": 16656,
          "gene_symbol": "ZNF350",
          "hgvs_c": "c.1414_1416delTCAinsCCC",
          "hgvs_p": "p.Ser472Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000523651.1",
          "strand": false,
          "transcript": "ENST00000853592.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 532,
          "aa_ref": "S",
          "aa_start": 472,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2317,
          "cdna_start": 1622,
          "cds_end": null,
          "cds_length": 1599,
          "cds_start": 1414,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 5,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000853593.1",
          "gene_hgnc_id": 16656,
          "gene_symbol": "ZNF350",
          "hgvs_c": "c.1414_1416delTCAinsCCC",
          "hgvs_p": "p.Ser472Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000523652.1",
          "strand": false,
          "transcript": "ENST00000853593.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 532,
          "aa_ref": "S",
          "aa_start": 472,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2465,
          "cdna_start": 1772,
          "cds_end": null,
          "cds_length": 1599,
          "cds_start": 1414,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000934229.1",
          "gene_hgnc_id": 16656,
          "gene_symbol": "ZNF350",
          "hgvs_c": "c.1414_1416delTCAinsCCC",
          "hgvs_p": "p.Ser472Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000604288.1",
          "strand": false,
          "transcript": "ENST00000934229.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 532,
          "aa_ref": "S",
          "aa_start": 472,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2409,
          "cdna_start": 1715,
          "cds_end": null,
          "cds_length": 1599,
          "cds_start": 1414,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 6,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000934230.1",
          "gene_hgnc_id": 16656,
          "gene_symbol": "ZNF350",
          "hgvs_c": "c.1414_1416delTCAinsCCC",
          "hgvs_p": "p.Ser472Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000604289.1",
          "strand": false,
          "transcript": "ENST00000934230.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 532,
          "aa_ref": "S",
          "aa_start": 472,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2395,
          "cdna_start": 1705,
          "cds_end": null,
          "cds_length": 1599,
          "cds_start": 1414,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 6,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000970659.1",
          "gene_hgnc_id": 16656,
          "gene_symbol": "ZNF350",
          "hgvs_c": "c.1414_1416delTCAinsCCC",
          "hgvs_p": "p.Ser472Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000640718.1",
          "strand": false,
          "transcript": "ENST00000970659.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 532,
          "aa_ref": "S",
          "aa_start": 472,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2446,
          "cdna_start": 1749,
          "cds_end": null,
          "cds_length": 1599,
          "cds_start": 1414,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 6,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000970660.1",
          "gene_hgnc_id": 16656,
          "gene_symbol": "ZNF350",
          "hgvs_c": "c.1414_1416delTCAinsCCC",
          "hgvs_p": "p.Ser472Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000640719.1",
          "strand": false,
          "transcript": "ENST00000970660.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 532,
          "aa_ref": "S",
          "aa_start": 472,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2369,
          "cdna_start": 2048,
          "cds_end": null,
          "cds_length": 1599,
          "cds_start": 1414,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000970661.1",
          "gene_hgnc_id": 16656,
          "gene_symbol": "ZNF350",
          "hgvs_c": "c.1414_1416delTCAinsCCC",
          "hgvs_p": "p.Ser472Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000640720.1",
          "strand": false,
          "transcript": "ENST00000970661.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 532,
          "aa_ref": "S",
          "aa_start": 472,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 3461,
          "cdna_start": 2485,
          "cds_end": null,
          "cds_length": 1599,
          "cds_start": 1414,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 4,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000970662.1",
          "gene_hgnc_id": 16656,
          "gene_symbol": "ZNF350",
          "hgvs_c": "c.1414_1416delTCAinsCCC",
          "hgvs_p": "p.Ser472Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000640721.1",
          "strand": false,
          "transcript": "ENST00000970662.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 574,
          "aa_ref": "S",
          "aa_start": 514,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2481,
          "cdna_start": 1784,
          "cds_end": null,
          "cds_length": 1725,
          "cds_start": 1540,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 6,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "XM_017027094.2",
          "gene_hgnc_id": 16656,
          "gene_symbol": "ZNF350",
          "hgvs_c": "c.1540_1542delTCAinsCCC",
          "hgvs_p": "p.Ser514Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_016882583.1",
          "strand": false,
          "transcript": "XM_017027094.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 574,
          "aa_ref": "S",
          "aa_start": 514,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2516,
          "cdna_start": 1819,
          "cds_end": null,
          "cds_length": 1725,
          "cds_start": 1540,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 6,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "XM_017027096.2",
          "gene_hgnc_id": 16656,
          "gene_symbol": "ZNF350",
          "hgvs_c": "c.1540_1542delTCAinsCCC",
          "hgvs_p": "p.Ser514Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_016882585.1",
          "strand": false,
          "transcript": "XM_017027096.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 574,
          "aa_ref": "S",
          "aa_start": 514,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2729,
          "cdna_start": 2032,
          "cds_end": null,
          "cds_length": 1725,
          "cds_start": 1540,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 7,
          "exon_rank": null,
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          "feature": "XM_047439182.1",
          "gene_hgnc_id": 16656,
          "gene_symbol": "ZNF350",
          "hgvs_c": "c.1540_1542delTCAinsCCC",
          "hgvs_p": "p.Ser514Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047295138.1",
          "strand": false,
          "transcript": "XM_047439182.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 574,
          "aa_ref": "S",
          "aa_start": 514,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2772,
          "cdna_start": 2075,
          "cds_end": null,
          "cds_length": 1725,
          "cds_start": 1540,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 8,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "XM_047439183.1",
          "gene_hgnc_id": 16656,
          "gene_symbol": "ZNF350",
          "hgvs_c": "c.1540_1542delTCAinsCCC",
          "hgvs_p": "p.Ser514Pro",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "XP_047295139.1",
          "strand": false,
          "transcript": "XM_047439183.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "P",
          "aa_end": null,
          "aa_length": 532,
          "aa_ref": "S",
          "aa_start": 472,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 2603,
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      "mitotip_prediction": null,
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      "pathogenicity_classification_combined": null,
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      "phylop100way_prediction": "Benign",
      "phylop100way_score": 0.863,
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      "transcript": "NM_021632.4"
    }
  ]
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.