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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 19-54636626-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=54636626&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "19",
"pos": 54636626,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_001081637.3",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1786G>C",
"hgvs_p": "p.Glu596Gln",
"transcript": "NM_001081637.3",
"protein_id": "NP_001075106.2",
"transcript_support_level": null,
"aa_start": 596,
"aa_end": null,
"aa_length": 652,
"cds_start": 1786,
"cds_end": null,
"cds_length": 1959,
"cdna_start": 1984,
"cdna_end": null,
"cdna_length": 3301,
"mane_select": "ENST00000324602.12",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001081637.3"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1786G>C",
"hgvs_p": "p.Glu596Gln",
"transcript": "ENST00000324602.12",
"protein_id": "ENSP00000315997.7",
"transcript_support_level": 5,
"aa_start": 596,
"aa_end": null,
"aa_length": 652,
"cds_start": 1786,
"cds_end": null,
"cds_length": 1959,
"cdna_start": 1984,
"cdna_end": null,
"cdna_length": 3301,
"mane_select": "NM_001081637.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000324602.12"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1786G>C",
"hgvs_p": "p.Glu596Gln",
"transcript": "ENST00000396315.5",
"protein_id": "ENSP00000379608.1",
"transcript_support_level": 1,
"aa_start": 596,
"aa_end": null,
"aa_length": 652,
"cds_start": 1786,
"cds_end": null,
"cds_length": 1959,
"cdna_start": 1786,
"cdna_end": null,
"cdna_length": 2157,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000396315.5"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1783G>C",
"hgvs_p": "p.Glu595Gln",
"transcript": "ENST00000396327.7",
"protein_id": "ENSP00000379618.3",
"transcript_support_level": 1,
"aa_start": 595,
"aa_end": null,
"aa_length": 651,
"cds_start": 1783,
"cds_end": null,
"cds_length": 1956,
"cdna_start": 2055,
"cdna_end": null,
"cdna_length": 2878,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000396327.7"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1783G>C",
"hgvs_p": "p.Glu595Gln",
"transcript": "ENST00000396332.8",
"protein_id": "ENSP00000379623.4",
"transcript_support_level": 1,
"aa_start": 595,
"aa_end": null,
"aa_length": 651,
"cds_start": 1783,
"cds_end": null,
"cds_length": 1956,
"cdna_start": 1953,
"cdna_end": null,
"cdna_length": 2776,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000396332.8"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1780G>C",
"hgvs_p": "p.Glu594Gln",
"transcript": "ENST00000396331.5",
"protein_id": "ENSP00000379622.1",
"transcript_support_level": 1,
"aa_start": 594,
"aa_end": null,
"aa_length": 650,
"cds_start": 1780,
"cds_end": null,
"cds_length": 1953,
"cdna_start": 2137,
"cdna_end": null,
"cdna_length": 2960,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000396331.5"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1732G>C",
"hgvs_p": "p.Glu578Gln",
"transcript": "ENST00000396317.5",
"protein_id": "ENSP00000379610.1",
"transcript_support_level": 1,
"aa_start": 578,
"aa_end": null,
"aa_length": 634,
"cds_start": 1732,
"cds_end": null,
"cds_length": 1905,
"cdna_start": 1732,
"cdna_end": null,
"cdna_length": 2103,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000396317.5"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1933G>C",
"hgvs_p": "p.Glu645Gln",
"transcript": "ENST00000427581.6",
"protein_id": "ENSP00000395004.2",
"transcript_support_level": 5,
"aa_start": 645,
"aa_end": null,
"aa_length": 701,
"cds_start": 1933,
"cds_end": null,
"cds_length": 2106,
"cdna_start": 2266,
"cdna_end": null,
"cdna_length": 2751,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000427581.6"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1816G>C",
"hgvs_p": "p.Glu606Gln",
"transcript": "ENST00000955136.1",
"protein_id": "ENSP00000625195.1",
"transcript_support_level": null,
"aa_start": 606,
"aa_end": null,
"aa_length": 662,
"cds_start": 1816,
"cds_end": null,
"cds_length": 1989,
"cdna_start": 2146,
"cdna_end": null,
"cdna_length": 3463,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955136.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1813G>C",
"hgvs_p": "p.Glu605Gln",
"transcript": "ENST00000890799.1",
"protein_id": "ENSP00000560858.1",
"transcript_support_level": null,
"aa_start": 605,
"aa_end": null,
"aa_length": 661,
"cds_start": 1813,
"cds_end": null,
"cds_length": 1986,
"cdna_start": 2011,
"cdna_end": null,
"cdna_length": 2863,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890799.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1813G>C",
"hgvs_p": "p.Glu605Gln",
"transcript": "ENST00000955144.1",
"protein_id": "ENSP00000625203.1",
"transcript_support_level": null,
"aa_start": 605,
"aa_end": null,
"aa_length": 661,
"cds_start": 1813,
"cds_end": null,
"cds_length": 1986,
"cdna_start": 2011,
"cdna_end": null,
"cdna_length": 2833,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955144.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1807G>C",
"hgvs_p": "p.Glu603Gln",
"transcript": "ENST00000955134.1",
"protein_id": "ENSP00000625193.1",
"transcript_support_level": null,
"aa_start": 603,
"aa_end": null,
"aa_length": 659,
"cds_start": 1807,
"cds_end": null,
"cds_length": 1980,
"cdna_start": 2172,
"cdna_end": null,
"cdna_length": 3487,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000955134.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1786G>C",
"hgvs_p": "p.Glu596Gln",
"transcript": "NM_001388358.1",
"protein_id": "NP_001375287.1",
"transcript_support_level": null,
"aa_start": 596,
"aa_end": null,
"aa_length": 652,
"cds_start": 1786,
"cds_end": null,
"cds_length": 1959,
"cdna_start": 2333,
"cdna_end": null,
"cdna_length": 3650,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001388358.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1783G>C",
"hgvs_p": "p.Glu595Gln",
"transcript": "NM_001081638.4",
"protein_id": "NP_001075107.2",
"transcript_support_level": null,
"aa_start": 595,
"aa_end": null,
"aa_length": 651,
"cds_start": 1783,
"cds_end": null,
"cds_length": 1956,
"cdna_start": 1981,
"cdna_end": null,
"cdna_length": 2832,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001081638.4"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1783G>C",
"hgvs_p": "p.Glu595Gln",
"transcript": "NM_001081639.4",
"protein_id": "NP_001075108.2",
"transcript_support_level": null,
"aa_start": 595,
"aa_end": null,
"aa_length": 651,
"cds_start": 1783,
"cds_end": null,
"cds_length": 1956,
"cdna_start": 1981,
"cdna_end": null,
"cdna_length": 2832,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001081639.4"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1783G>C",
"hgvs_p": "p.Glu595Gln",
"transcript": "NM_001388355.1",
"protein_id": "NP_001375284.1",
"transcript_support_level": null,
"aa_start": 595,
"aa_end": null,
"aa_length": 651,
"cds_start": 1783,
"cds_end": null,
"cds_length": 1956,
"cdna_start": 2182,
"cdna_end": null,
"cdna_length": 3499,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001388355.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1783G>C",
"hgvs_p": "p.Glu595Gln",
"transcript": "NM_001388356.1",
"protein_id": "NP_001375285.1",
"transcript_support_level": null,
"aa_start": 595,
"aa_end": null,
"aa_length": 651,
"cds_start": 1783,
"cds_end": null,
"cds_length": 1956,
"cdna_start": 2330,
"cdna_end": null,
"cdna_length": 3647,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001388356.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1783G>C",
"hgvs_p": "p.Glu595Gln",
"transcript": "NM_001388357.1",
"protein_id": "NP_001375286.1",
"transcript_support_level": null,
"aa_start": 595,
"aa_end": null,
"aa_length": 651,
"cds_start": 1783,
"cds_end": null,
"cds_length": 1956,
"cdna_start": 2330,
"cdna_end": null,
"cdna_length": 3647,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001388357.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1783G>C",
"hgvs_p": "p.Glu595Gln",
"transcript": "ENST00000890795.1",
"protein_id": "ENSP00000560854.1",
"transcript_support_level": null,
"aa_start": 595,
"aa_end": null,
"aa_length": 651,
"cds_start": 1783,
"cds_end": null,
"cds_length": 1956,
"cdna_start": 2364,
"cdna_end": null,
"cdna_length": 3680,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890795.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1783G>C",
"hgvs_p": "p.Glu595Gln",
"transcript": "ENST00000890796.1",
"protein_id": "ENSP00000560855.1",
"transcript_support_level": null,
"aa_start": 595,
"aa_end": null,
"aa_length": 651,
"cds_start": 1783,
"cds_end": null,
"cds_length": 1956,
"cdna_start": 2169,
"cdna_end": null,
"cdna_length": 3485,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890796.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1783G>C",
"hgvs_p": "p.Glu595Gln",
"transcript": "ENST00000890802.1",
"protein_id": "ENSP00000560861.1",
"transcript_support_level": null,
"aa_start": 595,
"aa_end": null,
"aa_length": 651,
"cds_start": 1783,
"cds_end": null,
"cds_length": 1956,
"cdna_start": 2064,
"cdna_end": null,
"cdna_length": 2606,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890802.1"
},
{
"aa_ref": "E",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LILRB1",
"gene_hgnc_id": 6605,
"hgvs_c": "c.1783G>C",
"hgvs_p": "p.Glu595Gln",
"transcript": "ENST00000890803.1",
"protein_id": "ENSP00000560862.1",
"transcript_support_level": null,
"aa_start": 595,
"aa_end": null,
"aa_length": 651,
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{
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{
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],
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"clinvar_review_status": "",
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"custom_annotations": null
}
],
"message": null
}