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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 19-56473006-T-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=19&pos=56473006&ref=T&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "19",
"pos": 56473006,
"ref": "T",
"alt": "C",
"effect": "intron_variant",
"transcript": "ENST00000504904.8",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ZNF667",
"gene_hgnc_id": 28854,
"hgvs_c": "c.-548-819A>G",
"hgvs_p": null,
"transcript": "NM_001321356.2",
"protein_id": "NP_001308285.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 610,
"cds_start": -4,
"cds_end": null,
"cds_length": 1833,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4401,
"mane_select": "ENST00000504904.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ZNF667",
"gene_hgnc_id": 28854,
"hgvs_c": "c.-548-819A>G",
"hgvs_p": null,
"transcript": "ENST00000504904.8",
"protein_id": "ENSP00000439402.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 610,
"cds_start": -4,
"cds_end": null,
"cds_length": 1833,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4401,
"mane_select": "NM_001321356.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ZNF667",
"gene_hgnc_id": 28854,
"hgvs_c": "c.-60+4266A>G",
"hgvs_p": null,
"transcript": "ENST00000292069.10",
"protein_id": "ENSP00000292069.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 610,
"cds_start": -4,
"cds_end": null,
"cds_length": 1833,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3832,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ZNF667",
"gene_hgnc_id": 28854,
"hgvs_c": "c.-1367A>G",
"hgvs_p": null,
"transcript": "ENST00000591790.5",
"protein_id": "ENSP00000468550.2",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 127,
"cds_start": -4,
"cds_end": null,
"cds_length": 384,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5250,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ZNF667",
"gene_hgnc_id": 28854,
"hgvs_c": "c.-60+4266A>G",
"hgvs_p": null,
"transcript": "NM_022103.4",
"protein_id": "NP_071386.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 610,
"cds_start": -4,
"cds_end": null,
"cds_length": 1833,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3799,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ZNF667",
"gene_hgnc_id": 28854,
"hgvs_c": "c.-332+4266A>G",
"hgvs_p": null,
"transcript": "NM_001321355.2",
"protein_id": "NP_001308284.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 553,
"cds_start": -4,
"cds_end": null,
"cds_length": 1662,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3900,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ZNF667",
"gene_hgnc_id": 28854,
"hgvs_c": "c.-60+5027A>G",
"hgvs_p": null,
"transcript": "ENST00000587555.5",
"protein_id": "ENSP00000468466.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": 157,
"cds_start": -4,
"cds_end": null,
"cds_length": 475,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 567,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ZNF667",
"gene_hgnc_id": 28854,
"hgvs_c": "c.-60+3903A>G",
"hgvs_p": null,
"transcript": "ENST00000589946.1",
"protein_id": "ENSP00000464708.1",
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": 83,
"cds_start": -4,
"cds_end": null,
"cds_length": 253,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 522,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ZNF667",
"gene_hgnc_id": 28854,
"hgvs_c": "n.1891-822A>G",
"hgvs_p": null,
"transcript": "ENST00000589652.1",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3593,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ZNF667",
"gene_hgnc_id": 28854,
"hgvs_c": "n.-60+4266A>G",
"hgvs_p": null,
"transcript": "ENST00000592189.5",
"protein_id": "ENSP00000467627.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3921,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ZNF667",
"gene_hgnc_id": 28854,
"hgvs_c": "c.-545-822A>G",
"hgvs_p": null,
"transcript": "XM_011527208.3",
"protein_id": "XP_011525510.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 610,
"cds_start": -4,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 5,
"intron_rank": 1,
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"gene_symbol": "ZNF667",
"gene_hgnc_id": 28854,
"hgvs_c": "c.-60+5027A>G",
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"transcript": "XM_024451637.2",
"protein_id": "XP_024307405.1",
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"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 1,
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"gene_symbol": "ZNF667",
"gene_hgnc_id": 28854,
"hgvs_c": "c.-1026-384A>G",
"hgvs_p": null,
"transcript": "XM_024451638.2",
"protein_id": "XP_024307406.1",
"transcript_support_level": null,
"aa_start": null,
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 8,
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"gene_symbol": "ZNF667",
"gene_hgnc_id": 28854,
"hgvs_c": "c.-665-384A>G",
"hgvs_p": null,
"transcript": "XM_024451640.2",
"protein_id": "XP_024307408.1",
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},
{
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],
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"gene_symbol": "ZNF667",
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"hgvs_c": "c.-548-819A>G",
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"transcript": "XM_024451641.2",
"protein_id": "XP_024307409.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ZNF667",
"gene_hgnc_id": 28854,
"hgvs_c": "c.-548-819A>G",
"hgvs_p": null,
"transcript": "XM_024451642.2",
"protein_id": "XP_024307410.1",
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},
{
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],
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"gene_symbol": "ZNF667",
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"hgvs_c": "c.-548-819A>G",
"hgvs_p": null,
"transcript": "XM_024451643.2",
"protein_id": "XP_024307411.1",
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"cds_start": -4,
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 1,
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"gene_symbol": "ZNF667",
"gene_hgnc_id": 28854,
"hgvs_c": "c.-545-822A>G",
"hgvs_p": null,
"transcript": "XM_024451644.2",
"protein_id": "XP_024307412.1",
"transcript_support_level": null,
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ZNF667",
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"hgvs_c": "c.-60+1006A>G",
"hgvs_p": null,
"transcript": "XM_024451645.2",
"protein_id": "XP_024307413.1",
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},
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],
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"gene_symbol": "ZNF667",
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"hgvs_c": "c.-60+4588A>G",
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"transcript": "XM_024451646.2",
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},
{
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"consequences": [
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],
"exon_rank": null,
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"gene_symbol": "ZNF667",
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"hgvs_c": "c.-60+4445A>G",
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"transcript": "XM_024451647.2",
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},
{
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"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ZNF667",
"gene_hgnc_id": 28854,
"hgvs_c": "c.-983-384A>G",
"hgvs_p": null,
"transcript": "XM_047439207.1",
"protein_id": "XP_047295163.1",
"transcript_support_level": null,
"aa_start": null,
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"cds_start": -4,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ZNF667",
"gene_hgnc_id": 28854,
"hgvs_c": "c.-545-822A>G",
"hgvs_p": null,
"transcript": "XM_047439208.1",
"protein_id": "XP_047295164.1",
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"aa_start": null,
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"cdna_start": null,
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"feature": null
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}
],
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}