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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-11587381-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=11587381&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 11587381,
"ref": "G",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000381486.7",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GREB1",
"gene_hgnc_id": 24885,
"hgvs_c": "c.1160-1365G>A",
"hgvs_p": null,
"transcript": "NM_014668.4",
"protein_id": "NP_055483.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1949,
"cds_start": -4,
"cds_end": null,
"cds_length": 5850,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8555,
"mane_select": "ENST00000381486.7",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GREB1",
"gene_hgnc_id": 24885,
"hgvs_c": "c.1160-1365G>A",
"hgvs_p": null,
"transcript": "ENST00000381486.7",
"protein_id": "ENSP00000370896.2",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1949,
"cds_start": -4,
"cds_end": null,
"cds_length": 5850,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8555,
"mane_select": "NM_014668.4",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": 8,
"intron_rank_end": null,
"gene_symbol": "GREB1",
"gene_hgnc_id": 24885,
"hgvs_c": "c.1160-1365G>A",
"hgvs_p": null,
"transcript": "ENST00000234142.9",
"protein_id": "ENSP00000234142.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1949,
"cds_start": -4,
"cds_end": null,
"cds_length": 5850,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8444,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GREB1",
"gene_hgnc_id": 24885,
"hgvs_c": "c.1160-1365G>A",
"hgvs_p": null,
"transcript": "ENST00000381483.6",
"protein_id": "ENSP00000370892.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 457,
"cds_start": -4,
"cds_end": null,
"cds_length": 1374,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2347,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_acceptor_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GREB1",
"gene_hgnc_id": 24885,
"hgvs_c": "c.1160-1G>A",
"hgvs_p": null,
"transcript": "ENST00000263834.9",
"protein_id": "ENSP00000263834.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 409,
"cds_start": -4,
"cds_end": null,
"cds_length": 1230,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2448,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GREB1",
"gene_hgnc_id": 24885,
"hgvs_c": "c.1160-1365G>A",
"hgvs_p": null,
"transcript": "NM_033090.3",
"protein_id": "NP_149081.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 457,
"cds_start": -4,
"cds_end": null,
"cds_length": 1374,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2386,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"splice_acceptor_variant",
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GREB1",
"gene_hgnc_id": 24885,
"hgvs_c": "c.1160-1G>A",
"hgvs_p": null,
"transcript": "NM_148903.3",
"protein_id": "NP_683701.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 409,
"cds_start": -4,
"cds_end": null,
"cds_length": 1230,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2472,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GREB1",
"gene_hgnc_id": 24885,
"hgvs_c": "c.1160-1365G>A",
"hgvs_p": null,
"transcript": "XM_005246192.5",
"protein_id": "XP_005246249.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1949,
"cds_start": -4,
"cds_end": null,
"cds_length": 5850,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8487,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GREB1",
"gene_hgnc_id": 24885,
"hgvs_c": "c.1160-1365G>A",
"hgvs_p": null,
"transcript": "XM_024453250.2",
"protein_id": "XP_024309018.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1949,
"cds_start": -4,
"cds_end": null,
"cds_length": 5850,
"cdna_start": null,
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"cdna_length": 8635,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GREB1",
"gene_hgnc_id": 24885,
"hgvs_c": "c.1160-1365G>A",
"hgvs_p": null,
"transcript": "XM_024453251.2",
"protein_id": "XP_024309019.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 33,
"intron_rank": 9,
"intron_rank_end": null,
"gene_symbol": "GREB1",
"gene_hgnc_id": 24885,
"hgvs_c": "c.1160-1365G>A",
"hgvs_p": null,
"transcript": "XM_024453253.2",
"protein_id": "XP_024309021.1",
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"feature": null
},
{
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"consequences": [
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],
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"gene_symbol": "GREB1",
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"hgvs_c": "c.1160-1365G>A",
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},
{
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"intron_rank": 9,
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"gene_symbol": "GREB1",
"gene_hgnc_id": 24885,
"hgvs_c": "c.1160-1365G>A",
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"transcript": "XM_047446460.1",
"protein_id": "XP_047302416.1",
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},
{
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],
"exon_rank": null,
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"gene_symbol": "GREB1",
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"hgvs_c": "c.1160-1365G>A",
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},
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],
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"hgvs_c": "c.1160-1365G>A",
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"transcript": "XM_011510419.4",
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},
{
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"strand": true,
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],
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"gene_symbol": "GREB1",
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"transcript": "XM_047446461.1",
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],
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"gene_symbol": "GREB1",
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"hgvs_c": "c.1160-1365G>A",
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"transcript": "XM_047446462.1",
"protein_id": "XP_047302418.1",
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},
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],
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"gene_symbol": "GREB1",
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"hgvs_c": "c.1160-1365G>A",
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"protein_id": "XP_047302419.1",
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},
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],
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"gene_symbol": "GREB1",
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},
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],
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},
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],
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"gene_symbol": "GREB1",
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"hgvs_c": "c.1160-1365G>A",
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"transcript": "XM_047446467.1",
"protein_id": "XP_047302423.1",
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},
{
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"protein_coding": true,
"strand": true,
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"intron_variant"
],
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"gene_symbol": "GREB1",
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"hgvs_c": "c.1160-1365G>A",
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}