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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-121367762-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=121367762&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 121367762,
"ref": "G",
"alt": "T",
"effect": "synonymous_variant",
"transcript": "NM_001395891.1",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 36,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3775C>A",
"hgvs_p": "p.Arg1259Arg",
"transcript": "NM_001395891.1",
"protein_id": "NP_001382820.1",
"transcript_support_level": null,
"aa_start": 1259,
"aa_end": null,
"aa_length": 1559,
"cds_start": 3775,
"cds_end": null,
"cds_length": 4680,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000696935.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001395891.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 36,
"exon_rank_end": null,
"exon_count": 41,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3775C>A",
"hgvs_p": "p.Arg1259Arg",
"transcript": "ENST00000696935.1",
"protein_id": "ENSP00000512981.1",
"transcript_support_level": null,
"aa_start": 1259,
"aa_end": null,
"aa_length": 1559,
"cds_start": 3775,
"cds_end": null,
"cds_length": 4680,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001395891.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000696935.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 35,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3712C>A",
"hgvs_p": "p.Arg1238Arg",
"transcript": "NM_015282.3",
"protein_id": "NP_056097.1",
"transcript_support_level": null,
"aa_start": 1238,
"aa_end": null,
"aa_length": 1538,
"cds_start": 3712,
"cds_end": null,
"cds_length": 4617,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_015282.3"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 35,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3712C>A",
"hgvs_p": "p.Arg1238Arg",
"transcript": "ENST00000263710.8",
"protein_id": "ENSP00000263710.4",
"transcript_support_level": 5,
"aa_start": 1238,
"aa_end": null,
"aa_length": 1538,
"cds_start": 3712,
"cds_end": null,
"cds_length": 4617,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000263710.8"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 35,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3655C>A",
"hgvs_p": "p.Arg1219Arg",
"transcript": "ENST00000961911.1",
"protein_id": "ENSP00000631970.1",
"transcript_support_level": null,
"aa_start": 1219,
"aa_end": null,
"aa_length": 1519,
"cds_start": 3655,
"cds_end": null,
"cds_length": 4560,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961911.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 34,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3631C>A",
"hgvs_p": "p.Arg1211Arg",
"transcript": "ENST00000961907.1",
"protein_id": "ENSP00000631966.1",
"transcript_support_level": null,
"aa_start": 1211,
"aa_end": null,
"aa_length": 1511,
"cds_start": 3631,
"cds_end": null,
"cds_length": 4536,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961907.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 34,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3631C>A",
"hgvs_p": "p.Arg1211Arg",
"transcript": "ENST00000961936.1",
"protein_id": "ENSP00000631995.1",
"transcript_support_level": null,
"aa_start": 1211,
"aa_end": null,
"aa_length": 1511,
"cds_start": 3631,
"cds_end": null,
"cds_length": 4536,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961936.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 34,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3616C>A",
"hgvs_p": "p.Arg1206Arg",
"transcript": "NM_001378003.1",
"protein_id": "NP_001364932.1",
"transcript_support_level": null,
"aa_start": 1206,
"aa_end": null,
"aa_length": 1506,
"cds_start": 3616,
"cds_end": null,
"cds_length": 4521,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001378003.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 34,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3610C>A",
"hgvs_p": "p.Arg1204Arg",
"transcript": "ENST00000961923.1",
"protein_id": "ENSP00000631982.1",
"transcript_support_level": null,
"aa_start": 1204,
"aa_end": null,
"aa_length": 1504,
"cds_start": 3610,
"cds_end": null,
"cds_length": 4515,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961923.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 34,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3607C>A",
"hgvs_p": "p.Arg1203Arg",
"transcript": "ENST00000961917.1",
"protein_id": "ENSP00000631976.1",
"transcript_support_level": null,
"aa_start": 1203,
"aa_end": null,
"aa_length": 1503,
"cds_start": 3607,
"cds_end": null,
"cds_length": 4512,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961917.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 33,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3607C>A",
"hgvs_p": "p.Arg1203Arg",
"transcript": "ENST00000961925.1",
"protein_id": "ENSP00000631984.1",
"transcript_support_level": null,
"aa_start": 1203,
"aa_end": null,
"aa_length": 1503,
"cds_start": 3607,
"cds_end": null,
"cds_length": 4512,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961925.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 34,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3607C>A",
"hgvs_p": "p.Arg1203Arg",
"transcript": "ENST00000961930.1",
"protein_id": "ENSP00000631989.1",
"transcript_support_level": null,
"aa_start": 1203,
"aa_end": null,
"aa_length": 1503,
"cds_start": 3607,
"cds_end": null,
"cds_length": 4512,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961930.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 33,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3583C>A",
"hgvs_p": "p.Arg1195Arg",
"transcript": "ENST00000877408.1",
"protein_id": "ENSP00000547467.1",
"transcript_support_level": null,
"aa_start": 1195,
"aa_end": null,
"aa_length": 1495,
"cds_start": 3583,
"cds_end": null,
"cds_length": 4488,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000877408.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 33,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3580C>A",
"hgvs_p": "p.Arg1194Arg",
"transcript": "ENST00000961920.1",
"protein_id": "ENSP00000631979.1",
"transcript_support_level": null,
"aa_start": 1194,
"aa_end": null,
"aa_length": 1494,
"cds_start": 3580,
"cds_end": null,
"cds_length": 4485,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961920.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 35,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3580C>A",
"hgvs_p": "p.Arg1194Arg",
"transcript": "ENST00000961932.1",
"protein_id": "ENSP00000631991.1",
"transcript_support_level": null,
"aa_start": 1194,
"aa_end": null,
"aa_length": 1494,
"cds_start": 3580,
"cds_end": null,
"cds_length": 4485,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961932.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 32,
"exon_rank_end": null,
"exon_count": 37,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3559C>A",
"hgvs_p": "p.Arg1187Arg",
"transcript": "ENST00000961928.1",
"protein_id": "ENSP00000631987.1",
"transcript_support_level": null,
"aa_start": 1187,
"aa_end": null,
"aa_length": 1487,
"cds_start": 3559,
"cds_end": null,
"cds_length": 4464,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961928.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 34,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3556C>A",
"hgvs_p": "p.Arg1186Arg",
"transcript": "ENST00000961919.1",
"protein_id": "ENSP00000631978.1",
"transcript_support_level": null,
"aa_start": 1186,
"aa_end": null,
"aa_length": 1486,
"cds_start": 3556,
"cds_end": null,
"cds_length": 4461,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961919.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 34,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3553C>A",
"hgvs_p": "p.Arg1185Arg",
"transcript": "ENST00000961910.1",
"protein_id": "ENSP00000631969.1",
"transcript_support_level": null,
"aa_start": 1185,
"aa_end": null,
"aa_length": 1485,
"cds_start": 3553,
"cds_end": null,
"cds_length": 4458,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961910.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 34,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3553C>A",
"hgvs_p": "p.Arg1185Arg",
"transcript": "ENST00000961926.1",
"protein_id": "ENSP00000631985.1",
"transcript_support_level": null,
"aa_start": 1185,
"aa_end": null,
"aa_length": 1485,
"cds_start": 3553,
"cds_end": null,
"cds_length": 4458,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961926.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 34,
"exon_rank_end": null,
"exon_count": 39,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3550C>A",
"hgvs_p": "p.Arg1184Arg",
"transcript": "ENST00000961915.1",
"protein_id": "ENSP00000631974.1",
"transcript_support_level": null,
"aa_start": 1184,
"aa_end": null,
"aa_length": 1484,
"cds_start": 3550,
"cds_end": null,
"cds_length": 4455,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961915.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 33,
"exon_rank_end": null,
"exon_count": 38,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3544C>A",
"hgvs_p": "p.Arg1182Arg",
"transcript": "ENST00000961927.1",
"protein_id": "ENSP00000631986.1",
"transcript_support_level": null,
"aa_start": 1182,
"aa_end": null,
"aa_length": 1482,
"cds_start": 3544,
"cds_end": null,
"cds_length": 4449,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000961927.1"
},
{
"aa_ref": "R",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 35,
"exon_rank_end": null,
"exon_count": 40,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CLASP1",
"gene_hgnc_id": 17088,
"hgvs_c": "c.3535C>A",
"hgvs_p": "p.Arg1179Arg",
"transcript": "NM_001142273.2",
"protein_id": "NP_001135745.1",
"transcript_support_level": null,
"aa_start": 1179,
"aa_end": null,
"aa_length": 1479,
"cds_start": 3535,
"cds_end": null,
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}
],
"message": null
}