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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-159213245-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=159213245&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 159213245,
"ref": "A",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000263635.8",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "TANC1",
"gene_hgnc_id": 29364,
"hgvs_c": "c.3245-4252A>G",
"hgvs_p": null,
"transcript": "NM_033394.3",
"protein_id": "NP_203752.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1861,
"cds_start": -4,
"cds_end": null,
"cds_length": 5586,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7501,
"mane_select": "ENST00000263635.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "TANC1",
"gene_hgnc_id": 29364,
"hgvs_c": "c.3245-4252A>G",
"hgvs_p": null,
"transcript": "ENST00000263635.8",
"protein_id": "ENSP00000263635.6",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 1861,
"cds_start": -4,
"cds_end": null,
"cds_length": 5586,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7501,
"mane_select": "NM_033394.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "TANC1",
"gene_hgnc_id": 29364,
"hgvs_c": "c.3224-4252A>G",
"hgvs_p": null,
"transcript": "NM_001350064.2",
"protein_id": "NP_001336993.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1854,
"cds_start": -4,
"cds_end": null,
"cds_length": 5565,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7480,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 28,
"intron_rank": 20,
"intron_rank_end": null,
"gene_symbol": "TANC1",
"gene_hgnc_id": 29364,
"hgvs_c": "c.3224-4252A>G",
"hgvs_p": null,
"transcript": "NM_001350065.2",
"protein_id": "NP_001336994.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1854,
"cds_start": -4,
"cds_end": null,
"cds_length": 5565,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7649,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": 17,
"intron_rank_end": null,
"gene_symbol": "TANC1",
"gene_hgnc_id": 29364,
"hgvs_c": "c.2876-4252A>G",
"hgvs_p": null,
"transcript": "NM_001350063.2",
"protein_id": "NP_001336992.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1738,
"cds_start": -4,
"cds_end": null,
"cds_length": 5217,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7132,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 16,
"intron_rank_end": null,
"gene_symbol": "TANC1",
"gene_hgnc_id": 29364,
"hgvs_c": "c.2642-4252A>G",
"hgvs_p": null,
"transcript": "NM_001350062.2",
"protein_id": "NP_001336991.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1660,
"cds_start": -4,
"cds_end": null,
"cds_length": 4983,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6898,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 27,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "TANC1",
"gene_hgnc_id": 29364,
"hgvs_c": "c.3221-4252A>G",
"hgvs_p": null,
"transcript": "NM_001145909.2",
"protein_id": "NP_001139381.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1390,
"cds_start": -4,
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"cds_length": 4173,
"cdna_start": null,
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"cdna_length": 7482,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "TANC1",
"gene_hgnc_id": 29364,
"hgvs_c": "n.37-4252A>G",
"hgvs_p": null,
"transcript": "ENST00000470074.1",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4351,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "TANC1",
"gene_hgnc_id": 29364,
"hgvs_c": "c.3329-4252A>G",
"hgvs_p": null,
"transcript": "XM_047446107.1",
"protein_id": "XP_047302063.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1889,
"cds_start": -4,
"cds_end": null,
"cds_length": 5670,
"cdna_start": null,
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"cdna_length": 7651,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 29,
"intron_rank": 21,
"intron_rank_end": null,
"gene_symbol": "TANC1",
"gene_hgnc_id": 29364,
"hgvs_c": "c.3326-4252A>G",
"hgvs_p": null,
"transcript": "XM_017005141.2",
"protein_id": "XP_016860630.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1888,
"cds_start": -4,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 25,
"intron_rank": 17,
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"gene_symbol": "TANC1",
"gene_hgnc_id": 29364,
"hgvs_c": "c.3311-4252A>G",
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"transcript": "XM_017005143.3",
"protein_id": "XP_016860632.1",
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},
{
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"consequences": [
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],
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},
{
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],
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"gene_symbol": "TANC1",
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},
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],
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"gene_symbol": "TANC1",
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"hgvs_c": "c.3299-4252A>G",
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},
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],
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},
{
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],
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"gene_symbol": "TANC1",
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"gene_symbol": "TANC1",
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"hgvs_c": "c.3272-4252A>G",
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},
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],
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"gene_symbol": "TANC1",
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"hgvs_c": "c.3254-4252A>G",
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"transcript": "XM_047446114.1",
"protein_id": "XP_047302070.1",
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],
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"gene_symbol": "TANC1",
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],
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],
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},
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"consequences": [
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],
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"gene_symbol": "TANC1",
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"hgvs_c": "c.3224-4252A>G",
"hgvs_p": null,
"transcript": "XM_047446117.1",
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},
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"consequences": [
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],
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"gene_symbol": "TANC1",
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"hgvs_c": "c.3224-4252A>G",
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