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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-165874215-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=165874215&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 165874215,
"ref": "A",
"alt": "G",
"effect": "3_prime_UTR_variant",
"transcript": "NM_024753.5",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TTC21B",
"gene_hgnc_id": 25660,
"hgvs_c": "c.*540T>C",
"hgvs_p": null,
"transcript": "NM_024753.5",
"protein_id": "NP_079029.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1316,
"cds_start": -4,
"cds_end": null,
"cds_length": 3951,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5415,
"mane_select": "ENST00000243344.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 29,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TTC21B",
"gene_hgnc_id": 25660,
"hgvs_c": "c.*540T>C",
"hgvs_p": null,
"transcript": "ENST00000243344.8",
"protein_id": "ENSP00000243344.7",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1316,
"cds_start": -4,
"cds_end": null,
"cds_length": 3951,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5415,
"mane_select": "NM_024753.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TTC21B",
"gene_hgnc_id": 25660,
"hgvs_c": "n.*540T>C",
"hgvs_p": null,
"transcript": "ENST00000679356.1",
"protein_id": "ENSP00000506245.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8329,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TTC21B",
"gene_hgnc_id": 25660,
"hgvs_c": "n.*540T>C",
"hgvs_p": null,
"transcript": "ENST00000679676.1",
"protein_id": "ENSP00000505492.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8223,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TTC21B",
"gene_hgnc_id": 25660,
"hgvs_c": "n.*540T>C",
"hgvs_p": null,
"transcript": "ENST00000679967.1",
"protein_id": "ENSP00000506607.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8323,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TTC21B",
"gene_hgnc_id": 25660,
"hgvs_c": "n.*3533T>C",
"hgvs_p": null,
"transcript": "ENST00000680327.1",
"protein_id": "ENSP00000506639.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8344,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TTC21B",
"gene_hgnc_id": 25660,
"hgvs_c": "n.*3743T>C",
"hgvs_p": null,
"transcript": "ENST00000680690.1",
"protein_id": "ENSP00000506121.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8408,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TTC21B",
"gene_hgnc_id": 25660,
"hgvs_c": "n.*540T>C",
"hgvs_p": null,
"transcript": "ENST00000680888.1",
"protein_id": "ENSP00000506276.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8367,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TTC21B",
"gene_hgnc_id": 25660,
"hgvs_c": "n.995T>C",
"hgvs_p": null,
"transcript": "ENST00000680904.1",
"protein_id": null,
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4730,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TTC21B",
"gene_hgnc_id": 25660,
"hgvs_c": "n.*3763T>C",
"hgvs_p": null,
"transcript": "ENST00000680947.1",
"protein_id": "ENSP00000506496.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 8188,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TTC21B",
"gene_hgnc_id": 25660,
"hgvs_c": "n.*4281T>C",
"hgvs_p": null,
"transcript": "ENST00000681024.1",
"protein_id": "ENSP00000506449.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
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"gene_symbol": "TTC21B",
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"hgvs_c": "n.*4222T>C",
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"transcript": "ENST00000681083.1",
"protein_id": "ENSP00000506095.1",
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"aa_start": null,
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"cds_start": -4,
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"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 24,
"exon_rank_end": null,
"exon_count": 26,
"intron_rank": null,
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"gene_symbol": "TTC21B",
"gene_hgnc_id": 25660,
"hgvs_c": "n.4369T>C",
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"transcript": "ENST00000681167.1",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": 30,
"exon_rank_end": null,
"exon_count": 32,
"intron_rank": null,
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"gene_symbol": "TTC21B",
"gene_hgnc_id": 25660,
"hgvs_c": "n.*7751T>C",
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"transcript": "ENST00000681502.1",
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},
{
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"protein_coding": false,
"strand": false,
"consequences": [
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],
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"exon_count": 29,
"intron_rank": null,
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"gene_symbol": "TTC21B",
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"hgvs_c": "n.*1301T>C",
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"transcript": "ENST00000681819.1",
"protein_id": "ENSP00000505673.1",
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"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
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"gene_symbol": "TTC21B",
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"hgvs_c": "n.*540T>C",
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"transcript": "ENST00000679356.1",
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},
{
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],
"exon_rank": 28,
"exon_rank_end": null,
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"intron_rank": null,
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"gene_symbol": "TTC21B",
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"hgvs_c": "n.*540T>C",
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"transcript": "ENST00000679676.1",
"protein_id": "ENSP00000505492.1",
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"feature": null
},
{
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"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
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"gene_symbol": "TTC21B",
"gene_hgnc_id": 25660,
"hgvs_c": "n.*540T>C",
"hgvs_p": null,
"transcript": "ENST00000679967.1",
"protein_id": "ENSP00000506607.1",
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"mane_select": null,
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"feature": null
},
{
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"protein_coding": false,
"strand": false,
"consequences": [
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],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
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"gene_symbol": "TTC21B",
"gene_hgnc_id": 25660,
"hgvs_c": "n.*3533T>C",
"hgvs_p": null,
"transcript": "ENST00000680327.1",
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},
{
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],
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"intron_rank": null,
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"gene_symbol": "TTC21B",
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"hgvs_c": "n.*3743T>C",
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},
{
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"strand": false,
"consequences": [
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],
"exon_rank": 29,
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"intron_rank": null,
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"gene_symbol": "TTC21B",
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 28,
"exon_rank_end": null,
"exon_count": 30,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TTC21B",
"gene_hgnc_id": 25660,
"hgvs_c": "n.*3763T>C",
"hgvs_p": null,
"transcript": "ENST00000680947.1",
"protein_id": "ENSP00000506496.1",
"transcript_support_level": null,
"aa_start": null,
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"aa_length": null,
"cds_start": -4,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"3_prime_UTR_variant"
],
"exon_rank": 29,
"exon_rank_end": null,
"exon_count": 31,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "TTC21B",
"gene_hgnc_id": 25660,
"hgvs_c": "n.*4281T>C",
"hgvs_p": null,
"transcript": "ENST00000681024.1",
"protein_id": "ENSP00000506449.1",
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}
],
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}