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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-169636123-G-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=169636123&ref=G&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 169636123,
"ref": "G",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_004792.3",
"consequences": [
{
"aa_ref": "R",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1049G>C",
"hgvs_p": "p.Arg350Thr",
"transcript": "NM_004792.3",
"protein_id": "NP_004783.2",
"transcript_support_level": null,
"aa_start": 350,
"aa_end": null,
"aa_length": 754,
"cds_start": 1049,
"cds_end": null,
"cds_length": 2265,
"cdna_start": 1258,
"cdna_end": null,
"cdna_length": 6357,
"mane_select": "ENST00000260970.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_004792.3"
},
{
"aa_ref": "R",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1049G>C",
"hgvs_p": "p.Arg350Thr",
"transcript": "ENST00000260970.8",
"protein_id": "ENSP00000260970.3",
"transcript_support_level": 1,
"aa_start": 350,
"aa_end": null,
"aa_length": 754,
"cds_start": 1049,
"cds_end": null,
"cds_length": 2265,
"cdna_start": 1258,
"cdna_end": null,
"cdna_length": 6357,
"mane_select": "NM_004792.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000260970.8"
},
{
"aa_ref": "R",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1049G>C",
"hgvs_p": "p.Arg350Thr",
"transcript": "ENST00000433207.6",
"protein_id": "ENSP00000408683.2",
"transcript_support_level": 1,
"aa_start": 350,
"aa_end": null,
"aa_length": 754,
"cds_start": 1049,
"cds_end": null,
"cds_length": 2265,
"cdna_start": 1267,
"cdna_end": null,
"cdna_length": 2776,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000433207.6"
},
{
"aa_ref": "R",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1049G>C",
"hgvs_p": "p.Arg350Thr",
"transcript": "ENST00000448752.7",
"protein_id": "ENSP00000407083.2",
"transcript_support_level": 1,
"aa_start": 350,
"aa_end": null,
"aa_length": 754,
"cds_start": 1049,
"cds_end": null,
"cds_length": 2265,
"cdna_start": 1207,
"cdna_end": null,
"cdna_length": 2861,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000448752.7"
},
{
"aa_ref": "R",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1004G>C",
"hgvs_p": "p.Arg335Thr",
"transcript": "ENST00000409714.7",
"protein_id": "ENSP00000386245.3",
"transcript_support_level": 1,
"aa_start": 335,
"aa_end": null,
"aa_length": 739,
"cds_start": 1004,
"cds_end": null,
"cds_length": 2220,
"cdna_start": 1211,
"cdna_end": null,
"cdna_length": 2615,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000409714.7"
},
{
"aa_ref": "R",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1049G>C",
"hgvs_p": "p.Arg350Thr",
"transcript": "ENST00000676756.1",
"protein_id": "ENSP00000503525.1",
"transcript_support_level": null,
"aa_start": 350,
"aa_end": null,
"aa_length": 754,
"cds_start": 1049,
"cds_end": null,
"cds_length": 2265,
"cdna_start": 1184,
"cdna_end": null,
"cdna_length": 6283,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000676756.1"
},
{
"aa_ref": "R",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1049G>C",
"hgvs_p": "p.Arg350Thr",
"transcript": "ENST00000678499.1",
"protein_id": "ENSP00000503136.1",
"transcript_support_level": null,
"aa_start": 350,
"aa_end": null,
"aa_length": 754,
"cds_start": 1049,
"cds_end": null,
"cds_length": 2265,
"cdna_start": 1371,
"cdna_end": null,
"cdna_length": 6453,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000678499.1"
},
{
"aa_ref": "R",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1049G>C",
"hgvs_p": "p.Arg350Thr",
"transcript": "ENST00000679107.1",
"protein_id": "ENSP00000502997.1",
"transcript_support_level": null,
"aa_start": 350,
"aa_end": null,
"aa_length": 754,
"cds_start": 1049,
"cds_end": null,
"cds_length": 2265,
"cdna_start": 1397,
"cdna_end": null,
"cdna_length": 6479,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000679107.1"
},
{
"aa_ref": "R",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1049G>C",
"hgvs_p": "p.Arg350Thr",
"transcript": "ENST00000935437.1",
"protein_id": "ENSP00000605496.1",
"transcript_support_level": null,
"aa_start": 350,
"aa_end": null,
"aa_length": 754,
"cds_start": 1049,
"cds_end": null,
"cds_length": 2265,
"cdna_start": 1324,
"cdna_end": null,
"cdna_length": 6417,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935437.1"
},
{
"aa_ref": "R",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1049G>C",
"hgvs_p": "p.Arg350Thr",
"transcript": "ENST00000951877.1",
"protein_id": "ENSP00000621936.1",
"transcript_support_level": null,
"aa_start": 350,
"aa_end": null,
"aa_length": 754,
"cds_start": 1049,
"cds_end": null,
"cds_length": 2265,
"cdna_start": 1746,
"cdna_end": null,
"cdna_length": 6839,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951877.1"
},
{
"aa_ref": "R",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1046G>C",
"hgvs_p": "p.Arg349Thr",
"transcript": "ENST00000935439.1",
"protein_id": "ENSP00000605498.1",
"transcript_support_level": null,
"aa_start": 349,
"aa_end": null,
"aa_length": 753,
"cds_start": 1046,
"cds_end": null,
"cds_length": 2262,
"cdna_start": 1264,
"cdna_end": null,
"cdna_length": 2706,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935439.1"
},
{
"aa_ref": "R",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1040G>C",
"hgvs_p": "p.Arg347Thr",
"transcript": "ENST00000678088.1",
"protein_id": "ENSP00000504661.1",
"transcript_support_level": null,
"aa_start": 347,
"aa_end": null,
"aa_length": 751,
"cds_start": 1040,
"cds_end": null,
"cds_length": 2256,
"cdna_start": 1258,
"cdna_end": null,
"cdna_length": 6341,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000678088.1"
},
{
"aa_ref": "R",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1040G>C",
"hgvs_p": "p.Arg347Thr",
"transcript": "ENST00000935438.1",
"protein_id": "ENSP00000605497.1",
"transcript_support_level": null,
"aa_start": 347,
"aa_end": null,
"aa_length": 751,
"cds_start": 1040,
"cds_end": null,
"cds_length": 2256,
"cdna_start": 1415,
"cdna_end": null,
"cdna_length": 6513,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935438.1"
},
{
"aa_ref": "R",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1040G>C",
"hgvs_p": "p.Arg347Thr",
"transcript": "ENST00000951878.1",
"protein_id": "ENSP00000621937.1",
"transcript_support_level": null,
"aa_start": 347,
"aa_end": null,
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"cds_start": 1040,
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"cdna_start": 1254,
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"cdna_length": 2691,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951878.1"
},
{
"aa_ref": "R",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1004G>C",
"hgvs_p": "p.Arg335Thr",
"transcript": "ENST00000951879.1",
"protein_id": "ENSP00000621938.1",
"transcript_support_level": null,
"aa_start": 335,
"aa_end": null,
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"cds_start": 1004,
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"cdna_start": 1173,
"cdna_end": null,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000951879.1"
},
{
"aa_ref": "R",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
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"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1049G>C",
"hgvs_p": "p.Arg350Thr",
"transcript": "ENST00000678638.1",
"protein_id": "ENSP00000504607.1",
"transcript_support_level": null,
"aa_start": 350,
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"aa_length": 732,
"cds_start": 1049,
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"cdna_start": 1218,
"cdna_end": null,
"cdna_length": 2661,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000678638.1"
},
{
"aa_ref": "R",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1049G>C",
"hgvs_p": "p.Arg350Thr",
"transcript": "ENST00000898369.1",
"protein_id": "ENSP00000568428.1",
"transcript_support_level": null,
"aa_start": 350,
"aa_end": null,
"aa_length": 732,
"cds_start": 1049,
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"cds_length": 2199,
"cdna_start": 1218,
"cdna_end": null,
"cdna_length": 2587,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898369.1"
},
{
"aa_ref": "R",
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1049G>C",
"hgvs_p": "p.Arg350Thr",
"transcript": "ENST00000935436.1",
"protein_id": "ENSP00000605495.1",
"transcript_support_level": null,
"aa_start": 350,
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"cdna_start": 1242,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000935436.1"
},
{
"aa_ref": "R",
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"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
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"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1049G>C",
"hgvs_p": "p.Arg350Thr",
"transcript": "ENST00000951876.1",
"protein_id": "ENSP00000621935.1",
"transcript_support_level": null,
"aa_start": 350,
"aa_end": null,
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"cds_start": 1049,
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"cdna_start": 1263,
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"mane_select": null,
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"biotype": "protein_coding",
"feature": "ENST00000951876.1"
},
{
"aa_ref": "R",
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"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.974G>C",
"hgvs_p": "p.Arg325Thr",
"transcript": "ENST00000935440.1",
"protein_id": "ENSP00000605499.1",
"transcript_support_level": null,
"aa_start": 325,
"aa_end": null,
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"cds_start": 974,
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"cdna_start": 1181,
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"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935440.1"
},
{
"aa_ref": "R",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 12,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.881G>C",
"hgvs_p": "p.Arg294Thr",
"transcript": "ENST00000935441.1",
"protein_id": "ENSP00000605500.1",
"transcript_support_level": null,
"aa_start": 294,
"aa_end": null,
"aa_length": 698,
"cds_start": 881,
"cds_end": null,
"cds_length": 2097,
"cdna_start": 1084,
"cdna_end": null,
"cdna_length": 2519,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935441.1"
},
{
"aa_ref": "R",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.824G>C",
"hgvs_p": "p.Arg275Thr",
"transcript": "ENST00000676508.1",
"protein_id": "ENSP00000503889.1",
"transcript_support_level": null,
"aa_start": 275,
"aa_end": null,
"aa_length": 679,
"cds_start": 824,
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}