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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-169636927-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=169636927&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 169636927,
"ref": "A",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_004792.3",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1669A>C",
"hgvs_p": "p.Ser557Arg",
"transcript": "NM_004792.3",
"protein_id": "NP_004783.2",
"transcript_support_level": null,
"aa_start": 557,
"aa_end": null,
"aa_length": 754,
"cds_start": 1669,
"cds_end": null,
"cds_length": 2265,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000260970.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_004792.3"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1669A>C",
"hgvs_p": "p.Ser557Arg",
"transcript": "ENST00000260970.8",
"protein_id": "ENSP00000260970.3",
"transcript_support_level": 1,
"aa_start": 557,
"aa_end": null,
"aa_length": 754,
"cds_start": 1669,
"cds_end": null,
"cds_length": 2265,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_004792.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000260970.8"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1669A>C",
"hgvs_p": "p.Ser557Arg",
"transcript": "ENST00000433207.6",
"protein_id": "ENSP00000408683.2",
"transcript_support_level": 1,
"aa_start": 557,
"aa_end": null,
"aa_length": 754,
"cds_start": 1669,
"cds_end": null,
"cds_length": 2265,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000433207.6"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1669A>C",
"hgvs_p": "p.Ser557Arg",
"transcript": "ENST00000448752.7",
"protein_id": "ENSP00000407083.2",
"transcript_support_level": 1,
"aa_start": 557,
"aa_end": null,
"aa_length": 754,
"cds_start": 1669,
"cds_end": null,
"cds_length": 2265,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000448752.7"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1624A>C",
"hgvs_p": "p.Ser542Arg",
"transcript": "ENST00000409714.7",
"protein_id": "ENSP00000386245.3",
"transcript_support_level": 1,
"aa_start": 542,
"aa_end": null,
"aa_length": 739,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2220,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000409714.7"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1669A>C",
"hgvs_p": "p.Ser557Arg",
"transcript": "ENST00000676756.1",
"protein_id": "ENSP00000503525.1",
"transcript_support_level": null,
"aa_start": 557,
"aa_end": null,
"aa_length": 754,
"cds_start": 1669,
"cds_end": null,
"cds_length": 2265,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000676756.1"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1669A>C",
"hgvs_p": "p.Ser557Arg",
"transcript": "ENST00000678499.1",
"protein_id": "ENSP00000503136.1",
"transcript_support_level": null,
"aa_start": 557,
"aa_end": null,
"aa_length": 754,
"cds_start": 1669,
"cds_end": null,
"cds_length": 2265,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000678499.1"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1669A>C",
"hgvs_p": "p.Ser557Arg",
"transcript": "ENST00000679107.1",
"protein_id": "ENSP00000502997.1",
"transcript_support_level": null,
"aa_start": 557,
"aa_end": null,
"aa_length": 754,
"cds_start": 1669,
"cds_end": null,
"cds_length": 2265,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000679107.1"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1669A>C",
"hgvs_p": "p.Ser557Arg",
"transcript": "ENST00000935437.1",
"protein_id": "ENSP00000605496.1",
"transcript_support_level": null,
"aa_start": 557,
"aa_end": null,
"aa_length": 754,
"cds_start": 1669,
"cds_end": null,
"cds_length": 2265,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935437.1"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1669A>C",
"hgvs_p": "p.Ser557Arg",
"transcript": "ENST00000951877.1",
"protein_id": "ENSP00000621936.1",
"transcript_support_level": null,
"aa_start": 557,
"aa_end": null,
"aa_length": 754,
"cds_start": 1669,
"cds_end": null,
"cds_length": 2265,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951877.1"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1666A>C",
"hgvs_p": "p.Ser556Arg",
"transcript": "ENST00000935439.1",
"protein_id": "ENSP00000605498.1",
"transcript_support_level": null,
"aa_start": 556,
"aa_end": null,
"aa_length": 753,
"cds_start": 1666,
"cds_end": null,
"cds_length": 2262,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935439.1"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1660A>C",
"hgvs_p": "p.Ser554Arg",
"transcript": "ENST00000678088.1",
"protein_id": "ENSP00000504661.1",
"transcript_support_level": null,
"aa_start": 554,
"aa_end": null,
"aa_length": 751,
"cds_start": 1660,
"cds_end": null,
"cds_length": 2256,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000678088.1"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1660A>C",
"hgvs_p": "p.Ser554Arg",
"transcript": "ENST00000935438.1",
"protein_id": "ENSP00000605497.1",
"transcript_support_level": null,
"aa_start": 554,
"aa_end": null,
"aa_length": 751,
"cds_start": 1660,
"cds_end": null,
"cds_length": 2256,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935438.1"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1660A>C",
"hgvs_p": "p.Ser554Arg",
"transcript": "ENST00000951878.1",
"protein_id": "ENSP00000621937.1",
"transcript_support_level": null,
"aa_start": 554,
"aa_end": null,
"aa_length": 751,
"cds_start": 1660,
"cds_end": null,
"cds_length": 2256,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951878.1"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1624A>C",
"hgvs_p": "p.Ser542Arg",
"transcript": "ENST00000951879.1",
"protein_id": "ENSP00000621938.1",
"transcript_support_level": null,
"aa_start": 542,
"aa_end": null,
"aa_length": 739,
"cds_start": 1624,
"cds_end": null,
"cds_length": 2220,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951879.1"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1603A>C",
"hgvs_p": "p.Ser535Arg",
"transcript": "ENST00000678638.1",
"protein_id": "ENSP00000504607.1",
"transcript_support_level": null,
"aa_start": 535,
"aa_end": null,
"aa_length": 732,
"cds_start": 1603,
"cds_end": null,
"cds_length": 2199,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000678638.1"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1603A>C",
"hgvs_p": "p.Ser535Arg",
"transcript": "ENST00000898369.1",
"protein_id": "ENSP00000568428.1",
"transcript_support_level": null,
"aa_start": 535,
"aa_end": null,
"aa_length": 732,
"cds_start": 1603,
"cds_end": null,
"cds_length": 2199,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000898369.1"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1603A>C",
"hgvs_p": "p.Ser535Arg",
"transcript": "ENST00000935436.1",
"protein_id": "ENSP00000605495.1",
"transcript_support_level": null,
"aa_start": 535,
"aa_end": null,
"aa_length": 732,
"cds_start": 1603,
"cds_end": null,
"cds_length": 2199,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935436.1"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1603A>C",
"hgvs_p": "p.Ser535Arg",
"transcript": "ENST00000951876.1",
"protein_id": "ENSP00000621935.1",
"transcript_support_level": null,
"aa_start": 535,
"aa_end": null,
"aa_length": 732,
"cds_start": 1603,
"cds_end": null,
"cds_length": 2199,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951876.1"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1594A>C",
"hgvs_p": "p.Ser532Arg",
"transcript": "ENST00000935440.1",
"protein_id": "ENSP00000605499.1",
"transcript_support_level": null,
"aa_start": 532,
"aa_end": null,
"aa_length": 729,
"cds_start": 1594,
"cds_end": null,
"cds_length": 2190,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935440.1"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1501A>C",
"hgvs_p": "p.Ser501Arg",
"transcript": "ENST00000935441.1",
"protein_id": "ENSP00000605500.1",
"transcript_support_level": null,
"aa_start": 501,
"aa_end": null,
"aa_length": 698,
"cds_start": 1501,
"cds_end": null,
"cds_length": 2097,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000935441.1"
},
{
"aa_ref": "S",
"aa_alt": "R",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PPIG",
"gene_hgnc_id": 14650,
"hgvs_c": "c.1444A>C",
"hgvs_p": "p.Ser482Arg",
"transcript": "ENST00000676508.1",
"protein_id": "ENSP00000503889.1",
"transcript_support_level": null,
"aa_start": 482,
"aa_end": null,
"aa_length": 679,
"cds_start": 1444,
"cds_end": null,
"cds_length": 2040,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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{
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}
],
"message": null
}