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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-169701576-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=169701576&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 169701576,
"ref": "A",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_001008489.4",
"consequences": [
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "NM_001008489.4",
"protein_id": "NP_001008489.1",
"transcript_support_level": null,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000359744.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001008489.4"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "ENST00000359744.8",
"protein_id": "ENSP00000352782.3",
"transcript_support_level": 1,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001008489.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000359744.8"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "NM_001199285.2",
"protein_id": "NP_001186214.1",
"transcript_support_level": null,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001199285.2"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "NM_001199286.2",
"protein_id": "NP_001186215.1",
"transcript_support_level": null,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001199286.2"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "NM_001199287.2",
"protein_id": "NP_001186216.1",
"transcript_support_level": null,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001199287.2"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "NM_001199288.2",
"protein_id": "NP_001186217.1",
"transcript_support_level": null,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001199288.2"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "ENST00000616481.4",
"protein_id": "ENSP00000481680.1",
"transcript_support_level": 3,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000616481.4"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "ENST00000616524.4",
"protein_id": "ENSP00000481046.1",
"transcript_support_level": 3,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000616524.4"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "ENST00000617738.4",
"protein_id": "ENSP00000481857.1",
"transcript_support_level": 2,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000617738.4"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "ENST00000857416.1",
"protein_id": "ENSP00000527475.1",
"transcript_support_level": null,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000857416.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "ENST00000857417.1",
"protein_id": "ENSP00000527476.1",
"transcript_support_level": null,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000857417.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "ENST00000857418.1",
"protein_id": "ENSP00000527477.1",
"transcript_support_level": null,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000857418.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "ENST00000857419.1",
"protein_id": "ENSP00000527478.1",
"transcript_support_level": null,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000857419.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "ENST00000857420.1",
"protein_id": "ENSP00000527479.1",
"transcript_support_level": null,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000857420.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "ENST00000857421.1",
"protein_id": "ENSP00000527480.1",
"transcript_support_level": null,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000857421.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "ENST00000857422.1",
"protein_id": "ENSP00000527481.1",
"transcript_support_level": null,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000857422.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "ENST00000857423.1",
"protein_id": "ENSP00000527482.1",
"transcript_support_level": null,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000857423.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "ENST00000857424.1",
"protein_id": "ENSP00000527483.1",
"transcript_support_level": null,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000857424.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "ENST00000931227.1",
"protein_id": "ENSP00000601286.1",
"transcript_support_level": null,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931227.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "ENST00000931228.1",
"protein_id": "ENSP00000601287.1",
"transcript_support_level": null,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931228.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "ENST00000931229.1",
"protein_id": "ENSP00000601288.1",
"transcript_support_level": null,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000931229.1"
},
{
"aa_ref": "Y",
"aa_alt": "C",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "PHOSPHO2",
"gene_hgnc_id": 28316,
"hgvs_c": "c.605A>G",
"hgvs_p": "p.Tyr202Cys",
"transcript": "ENST00000931230.1",
"protein_id": "ENSP00000601289.1",
"transcript_support_level": null,
"aa_start": 202,
"aa_end": null,
"aa_length": 241,
"cds_start": 605,
"cds_end": null,
"cds_length": 726,
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