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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-173358836-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=173358836&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "2",
      "pos": 173358836,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant,splice_region_variant",
      "transcript": "NM_031942.5",
      "consequences": [
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "c.146C>T",
          "hgvs_p": "p.Thr49Met",
          "transcript": "NM_031942.5",
          "protein_id": "NP_114148.3",
          "transcript_support_level": null,
          "aa_start": 49,
          "aa_end": null,
          "aa_length": 450,
          "cds_start": 146,
          "cds_end": null,
          "cds_length": 1353,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000306721.8",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_031942.5"
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "c.146C>T",
          "hgvs_p": "p.Thr49Met",
          "transcript": "ENST00000306721.8",
          "protein_id": "ENSP00000306968.3",
          "transcript_support_level": 2,
          "aa_start": 49,
          "aa_end": null,
          "aa_length": 450,
          "cds_start": 146,
          "cds_end": null,
          "cds_length": 1353,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_031942.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000306721.8"
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "c.146C>T",
          "hgvs_p": "p.Thr49Met",
          "transcript": "ENST00000347703.7",
          "protein_id": "ENSP00000272789.4",
          "transcript_support_level": 1,
          "aa_start": 49,
          "aa_end": null,
          "aa_length": 371,
          "cds_start": 146,
          "cds_end": null,
          "cds_length": 1116,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000347703.7"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "n.217C>T",
          "hgvs_p": null,
          "transcript": "ENST00000467411.5",
          "protein_id": null,
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000467411.5"
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "c.146C>T",
          "hgvs_p": "p.Thr49Met",
          "transcript": "ENST00000911359.1",
          "protein_id": "ENSP00000581418.1",
          "transcript_support_level": null,
          "aa_start": 49,
          "aa_end": null,
          "aa_length": 451,
          "cds_start": 146,
          "cds_end": null,
          "cds_length": 1356,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000911359.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "c.143C>T",
          "hgvs_p": "p.Thr48Met",
          "transcript": "ENST00000695912.1",
          "protein_id": "ENSP00000512263.1",
          "transcript_support_level": null,
          "aa_start": 48,
          "aa_end": null,
          "aa_length": 449,
          "cds_start": 143,
          "cds_end": null,
          "cds_length": 1350,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000695912.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "c.146C>T",
          "hgvs_p": "p.Thr49Met",
          "transcript": "ENST00000911364.1",
          "protein_id": "ENSP00000581423.1",
          "transcript_support_level": null,
          "aa_start": 49,
          "aa_end": null,
          "aa_length": 441,
          "cds_start": 146,
          "cds_end": null,
          "cds_length": 1326,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000911364.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 10,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "c.146C>T",
          "hgvs_p": "p.Thr49Met",
          "transcript": "ENST00000410101.7",
          "protein_id": "ENSP00000386656.3",
          "transcript_support_level": 2,
          "aa_start": 49,
          "aa_end": null,
          "aa_length": 406,
          "cds_start": 146,
          "cds_end": null,
          "cds_length": 1221,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000410101.7"
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "c.146C>T",
          "hgvs_p": "p.Thr49Met",
          "transcript": "ENST00000858243.1",
          "protein_id": "ENSP00000528302.1",
          "transcript_support_level": null,
          "aa_start": 49,
          "aa_end": null,
          "aa_length": 400,
          "cds_start": 146,
          "cds_end": null,
          "cds_length": 1203,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000858243.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "c.146C>T",
          "hgvs_p": "p.Thr49Met",
          "transcript": "ENST00000911358.1",
          "protein_id": "ENSP00000581417.1",
          "transcript_support_level": null,
          "aa_start": 49,
          "aa_end": null,
          "aa_length": 385,
          "cds_start": 146,
          "cds_end": null,
          "cds_length": 1158,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000911358.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "c.146C>T",
          "hgvs_p": "p.Thr49Met",
          "transcript": "ENST00000858244.1",
          "protein_id": "ENSP00000528303.1",
          "transcript_support_level": null,
          "aa_start": 49,
          "aa_end": null,
          "aa_length": 372,
          "cds_start": 146,
          "cds_end": null,
          "cds_length": 1119,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000858244.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "c.146C>T",
          "hgvs_p": "p.Thr49Met",
          "transcript": "NM_145810.3",
          "protein_id": "NP_665809.1",
          "transcript_support_level": null,
          "aa_start": 49,
          "aa_end": null,
          "aa_length": 371,
          "cds_start": 146,
          "cds_end": null,
          "cds_length": 1116,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_145810.3"
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "c.143C>T",
          "hgvs_p": "p.Thr48Met",
          "transcript": "ENST00000695914.1",
          "protein_id": "ENSP00000512265.1",
          "transcript_support_level": null,
          "aa_start": 48,
          "aa_end": null,
          "aa_length": 370,
          "cds_start": 143,
          "cds_end": null,
          "cds_length": 1113,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000695914.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 9,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "c.146C>T",
          "hgvs_p": "p.Thr49Met",
          "transcript": "ENST00000911362.1",
          "protein_id": "ENSP00000581421.1",
          "transcript_support_level": null,
          "aa_start": 49,
          "aa_end": null,
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          "cds_start": 146,
          "cds_end": null,
          "cds_length": 1107,
          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000911362.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "c.146C>T",
          "hgvs_p": "p.Thr49Met",
          "transcript": "ENST00000695901.1",
          "protein_id": "ENSP00000512251.1",
          "transcript_support_level": null,
          "aa_start": 49,
          "aa_end": null,
          "aa_length": 321,
          "cds_start": 146,
          "cds_end": null,
          "cds_length": 966,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000695901.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "c.146C>T",
          "hgvs_p": "p.Thr49Met",
          "transcript": "ENST00000911360.1",
          "protein_id": "ENSP00000581419.1",
          "transcript_support_level": null,
          "aa_start": 49,
          "aa_end": null,
          "aa_length": 306,
          "cds_start": 146,
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          "cds_length": 921,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000911360.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "c.146C>T",
          "hgvs_p": "p.Thr49Met",
          "transcript": "ENST00000911361.1",
          "protein_id": "ENSP00000581420.1",
          "transcript_support_level": null,
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          "aa_length": 266,
          "cds_start": 146,
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          "cds_length": 801,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000911361.1"
        },
        {
          "aa_ref": "T",
          "aa_alt": "M",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant",
            "splice_region_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "c.146C>T",
          "hgvs_p": "p.Thr49Met",
          "transcript": "XM_047445957.1",
          "protein_id": "XP_047301913.1",
          "transcript_support_level": null,
          "aa_start": 49,
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          "cds_start": 146,
          "cds_end": null,
          "cds_length": 732,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047445957.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "c.21+3852C>T",
          "hgvs_p": null,
          "transcript": "ENST00000410019.3",
          "protein_id": "ENSP00000386833.3",
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 329,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 990,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000410019.3"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": 1,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "c.21+3852C>T",
          "hgvs_p": null,
          "transcript": "ENST00000911363.1",
          "protein_id": "ENSP00000581422.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 279,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 840,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000911363.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "n.146C>T",
          "hgvs_p": null,
          "transcript": "ENST00000435616.5",
          "protein_id": "ENSP00000390470.1",
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000435616.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 1,
          "exon_rank_end": null,
          "exon_count": 5,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "n.330C>T",
          "hgvs_p": null,
          "transcript": "ENST00000468359.1",
          "protein_id": null,
          "transcript_support_level": 3,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000468359.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "n.238C>T",
          "hgvs_p": null,
          "transcript": "ENST00000496441.5",
          "protein_id": null,
          "transcript_support_level": 2,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "retained_intron",
          "feature": "ENST00000496441.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "splice_region_variant",
            "non_coding_transcript_exon_variant"
          ],
          "exon_rank": 2,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "CDCA7",
          "gene_hgnc_id": 14628,
          "hgvs_c": "n.146C>T",
          "hgvs_p": null,
          "transcript": "ENST00000695913.1",
          "protein_id": "ENSP00000512264.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000695913.1"
        }
      ],
      "gene_symbol": "CDCA7",
      "gene_hgnc_id": 14628,
      "dbsnp": "rs758866134",
      "frequency_reference_population": 0.000017810122,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 26,
      "gnomad_exomes_af": 0.0000178101,
      "gnomad_genomes_af": null,
      "gnomad_exomes_ac": 26,
      "gnomad_genomes_ac": null,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": null,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.30175936222076416,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0.8140000104904175,
      "splice_prediction_selected": "Pathogenic",
      "splice_source_selected": "dbscSNV1_RF",
      "revel_score": 0.379,
      "revel_prediction": "Uncertain_significance",
      "alphamissense_score": 0.1562,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.21,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 7.12,
      "phylop100way_prediction": "Uncertain_significance",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": 0.995612331766151,
      "dbscsnv_ada_prediction": "Pathogenic",
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 1,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PP3",
      "acmg_by_gene": [
        {
          "score": 1,
          "benign_score": 0,
          "pathogenic_score": 1,
          "criteria": [
            "PP3"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_031942.5",
          "gene_symbol": "CDCA7",
          "hgnc_id": 14628,
          "effects": [
            "missense_variant",
            "splice_region_variant"
          ],
          "inheritance_mode": "AR",
          "hgvs_c": "c.146C>T",
          "hgvs_p": "p.Thr49Met"
        }
      ],
      "clinvar_disease": "not provided",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not provided",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}