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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-178542948-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=178542948&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "2",
      "pos": 178542948,
      "ref": "C",
      "alt": "T",
      "effect": "splice_region_variant,synonymous_variant",
      "transcript": "NM_001267550.2",
      "consequences": [
        {
          "aa_ref": "V",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "synonymous_variant"
          ],
          "exon_rank": 348,
          "exon_rank_end": null,
          "exon_count": 363,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTN",
          "gene_hgnc_id": 12403,
          "hgvs_c": "c.96906G>A",
          "hgvs_p": "p.Val32302Val",
          "transcript": "NM_001267550.2",
          "protein_id": "NP_001254479.2",
          "transcript_support_level": null,
          "aa_start": 32302,
          "aa_end": null,
          "aa_length": 35991,
          "cds_start": 96906,
          "cds_end": null,
          "cds_length": 107976,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000589042.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001267550.2"
        },
        {
          "aa_ref": "V",
          "aa_alt": "V",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "synonymous_variant"
          ],
          "exon_rank": 348,
          "exon_rank_end": null,
          "exon_count": 363,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTN",
          "gene_hgnc_id": 12403,
          "hgvs_c": "c.96906G>A",
          "hgvs_p": "p.Val32302Val",
          "transcript": "ENST00000589042.5",
          "protein_id": "ENSP00000467141.1",
          "transcript_support_level": 5,
          "aa_start": 32302,
          "aa_end": null,
          "aa_length": 35991,
          "cds_start": 96906,
          "cds_end": null,
          "cds_length": 107976,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_001267550.2",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000589042.5"
        },
        {
          "aa_ref": "V",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "synonymous_variant"
          ],
          "exon_rank": 346,
          "exon_rank_end": null,
          "exon_count": 361,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTN",
          "gene_hgnc_id": 12403,
          "hgvs_c": "c.96750G>A",
          "hgvs_p": "p.Val32250Val",
          "transcript": "ENST00000446966.2",
          "protein_id": "ENSP00000408004.2",
          "transcript_support_level": 1,
          "aa_start": 32250,
          "aa_end": null,
          "aa_length": 35939,
          "cds_start": 96750,
          "cds_end": null,
          "cds_length": 107820,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000446966.2"
        },
        {
          "aa_ref": "V",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "synonymous_variant"
          ],
          "exon_rank": 346,
          "exon_rank_end": null,
          "exon_count": 361,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTN",
          "gene_hgnc_id": 12403,
          "hgvs_c": "c.96630G>A",
          "hgvs_p": "p.Val32210Val",
          "transcript": "ENST00000436599.2",
          "protein_id": "ENSP00000405517.2",
          "transcript_support_level": 1,
          "aa_start": 32210,
          "aa_end": null,
          "aa_length": 35899,
          "cds_start": 96630,
          "cds_end": null,
          "cds_length": 107700,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000436599.2"
        },
        {
          "aa_ref": "V",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "synonymous_variant"
          ],
          "exon_rank": 341,
          "exon_rank_end": null,
          "exon_count": 356,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTN",
          "gene_hgnc_id": 12403,
          "hgvs_c": "c.96348G>A",
          "hgvs_p": "p.Val32116Val",
          "transcript": "ENST00000426232.6",
          "protein_id": "ENSP00000392336.2",
          "transcript_support_level": 1,
          "aa_start": 32116,
          "aa_end": null,
          "aa_length": 35805,
          "cds_start": 96348,
          "cds_end": null,
          "cds_length": 107418,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000426232.6"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": false,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": 7,
          "intron_rank_end": null,
          "gene_symbol": "TTN-AS1",
          "gene_hgnc_id": 44124,
          "hgvs_c": "n.2043+587C>T",
          "hgvs_p": null,
          "transcript": "ENST00000419746.5",
          "protein_id": null,
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": null,
          "cds_start": null,
          "cds_end": null,
          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "pseudogene",
          "feature": "ENST00000419746.5"
        },
        {
          "aa_ref": "V",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "synonymous_variant"
          ],
          "exon_rank": 350,
          "exon_rank_end": null,
          "exon_count": 365,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTN",
          "gene_hgnc_id": 12403,
          "hgvs_c": "c.96906G>A",
          "hgvs_p": "p.Val32302Val",
          "transcript": "ENST00000412264.2",
          "protein_id": "ENSP00000394672.2",
          "transcript_support_level": 3,
          "aa_start": 32302,
          "aa_end": null,
          "aa_length": 35991,
          "cds_start": 96906,
          "cds_end": null,
          "cds_length": 107976,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000412264.2"
        },
        {
          "aa_ref": "V",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "synonymous_variant"
          ],
          "exon_rank": 347,
          "exon_rank_end": null,
          "exon_count": 362,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTN",
          "gene_hgnc_id": 12403,
          "hgvs_c": "c.96822G>A",
          "hgvs_p": "p.Val32274Val",
          "transcript": "ENST00000425332.3",
          "protein_id": "ENSP00000396805.3",
          "transcript_support_level": 5,
          "aa_start": 32274,
          "aa_end": null,
          "aa_length": 35963,
          "cds_start": 96822,
          "cds_end": null,
          "cds_length": 107892,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000425332.3"
        },
        {
          "aa_ref": "V",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "synonymous_variant"
          ],
          "exon_rank": 345,
          "exon_rank_end": null,
          "exon_count": 360,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTN",
          "gene_hgnc_id": 12403,
          "hgvs_c": "c.96492G>A",
          "hgvs_p": "p.Val32164Val",
          "transcript": "ENST00000715174.1",
          "protein_id": "ENSP00000520370.1",
          "transcript_support_level": null,
          "aa_start": 32164,
          "aa_end": null,
          "aa_length": 35853,
          "cds_start": 96492,
          "cds_end": null,
          "cds_length": 107562,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000715174.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "synonymous_variant"
          ],
          "exon_rank": 298,
          "exon_rank_end": null,
          "exon_count": 313,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTN",
          "gene_hgnc_id": 12403,
          "hgvs_c": "c.91983G>A",
          "hgvs_p": "p.Val30661Val",
          "transcript": "NM_001256850.1",
          "protein_id": "NP_001243779.1",
          "transcript_support_level": null,
          "aa_start": 30661,
          "aa_end": null,
          "aa_length": 34350,
          "cds_start": 91983,
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          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001256850.1"
        },
        {
          "aa_ref": "V",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "synonymous_variant"
          ],
          "exon_rank": 298,
          "exon_rank_end": null,
          "exon_count": 313,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTN",
          "gene_hgnc_id": 12403,
          "hgvs_c": "c.91983G>A",
          "hgvs_p": "p.Val30661Val",
          "transcript": "ENST00000591111.5",
          "protein_id": "ENSP00000465570.1",
          "transcript_support_level": 5,
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          "aa_end": null,
          "aa_length": 34350,
          "cds_start": 91983,
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          "cdna_start": null,
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        },
        {
          "aa_ref": "V",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "synonymous_variant"
          ],
          "exon_rank": 297,
          "exon_rank_end": null,
          "exon_count": 312,
          "intron_rank": null,
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          "gene_symbol": "TTN",
          "gene_hgnc_id": 12403,
          "hgvs_c": "c.89202G>A",
          "hgvs_p": "p.Val29734Val",
          "transcript": "NM_133378.4",
          "protein_id": "NP_596869.4",
          "transcript_support_level": null,
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          "aa_length": 33423,
          "cds_start": 89202,
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          "cdna_start": null,
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          "biotype": "protein_coding",
          "feature": "NM_133378.4"
        },
        {
          "aa_ref": "V",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "synonymous_variant"
          ],
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          "exon_rank_end": null,
          "exon_count": 312,
          "intron_rank": null,
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          "gene_symbol": "TTN",
          "gene_hgnc_id": 12403,
          "hgvs_c": "c.89202G>A",
          "hgvs_p": "p.Val29734Val",
          "transcript": "ENST00000342992.11",
          "protein_id": "ENSP00000343764.6",
          "transcript_support_level": 5,
          "aa_start": 29734,
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          "aa_length": 33423,
          "cds_start": 89202,
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          "biotype": "protein_coding",
          "feature": "ENST00000342992.11"
        },
        {
          "aa_ref": "V",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
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            "splice_region_variant",
            "synonymous_variant"
          ],
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          "exon_rank_end": null,
          "exon_count": 192,
          "intron_rank": null,
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          "gene_symbol": "TTN",
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          "hgvs_p": "p.Val23429Val",
          "transcript": "NM_133437.4",
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        },
        {
          "aa_ref": "V",
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          ],
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          "intron_rank": null,
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          "gene_symbol": "TTN",
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          "hgvs_c": "c.70287G>A",
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          "transcript": "ENST00000342175.12",
          "protein_id": "ENSP00000340554.6",
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        },
        {
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          "consequences": [
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          "exon_count": 192,
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          "gene_symbol": "TTN",
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          "hgvs_c": "c.70086G>A",
          "hgvs_p": "p.Val23362Val",
          "transcript": "NM_133432.3",
          "protein_id": "NP_597676.3",
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          "biotype": "protein_coding",
          "feature": "NM_133432.3"
        },
        {
          "aa_ref": "V",
          "aa_alt": "V",
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          "protein_coding": true,
          "strand": false,
          "consequences": [
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        {
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          "intron_rank": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "V",
          "aa_alt": "V",
          "canonical": false,
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          "consequences": [
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            "synonymous_variant"
          ],
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          "exon_rank_end": null,
          "exon_count": 191,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "TTN",
          "gene_hgnc_id": 12403,
          "hgvs_c": "c.69711G>A",
          "hgvs_p": "p.Val23237Val",
          "transcript": "ENST00000460472.6",
          "protein_id": "ENSP00000434586.1",
          "transcript_support_level": 5,
          "aa_start": 23237,
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          "aa_length": 26926,
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          "biotype": "protein_coding",
          "feature": "ENST00000460472.6"
        },
        {
          "aa_ref": "V",
          "aa_alt": "V",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "splice_region_variant",
            "synonymous_variant"
          ],
          "exon_rank": 344,
          "exon_rank_end": null,
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      "computational_score_selected": -0.5899999737739563,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "BayesDel_noAF",
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      "splice_prediction_selected": "Benign",
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      "alphamissense_score": null,
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      "bayesdelnoaf_score": -0.59,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": -0.021,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0.03,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": 0.000151442643207669,
      "dbscsnv_ada_prediction": "Benign",
      "apogee2_score": null,
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      "mitotip_score": null,
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      "acmg_score": -13,
      "acmg_classification": "Benign",
      "acmg_criteria": "BP4_Strong,BP6_Very_Strong,BP7",
      "acmg_by_gene": [
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          "pathogenic_score": 0,
          "criteria": [
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            "BP6_Very_Strong",
            "BP7"
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          "verdict": "Benign",
          "transcript": "NM_001267550.2",
          "gene_symbol": "TTN",
          "hgnc_id": 12403,
          "effects": [
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            "synonymous_variant"
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          "inheritance_mode": "AD,AR",
          "hgvs_c": "c.96906G>A",
          "hgvs_p": "p.Val32302Val"
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        {
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          "benign_score": 12,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Strong",
            "BP6_Very_Strong"
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          "verdict": "Benign",
          "transcript": "ENST00000590040.5",
          "gene_symbol": "TTN-AS1",
          "hgnc_id": 44124,
          "effects": [
            "non_coding_transcript_exon_variant"
          ],
          "inheritance_mode": "",
          "hgvs_c": "n.618C>T",
          "hgvs_p": null
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      ],
      "clinvar_disease": "Autosomal recessive limb-girdle muscular dystrophy type 2J,Cardiovascular phenotype,Dilated cardiomyopathy 1G",
      "clinvar_classification": "Likely benign",
      "clinvar_review_status": "criteria provided, multiple submitters, no conflicts",
      "clinvar_submissions_summary": "LB:2",
      "phenotype_combined": "Autosomal recessive limb-girdle muscular dystrophy type 2J;Dilated cardiomyopathy 1G|Cardiovascular phenotype",
      "pathogenicity_classification_combined": "Likely benign",
      "custom_annotations": null
    }
  ],
  "message": null
}
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