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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-178609299-TCG-CAA (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=178609299&ref=TCG&alt=CAA&genome=hg38&allGenes=true"

API Response

json
{
  "message": null,
  "variants": [
    {
      "acmg_by_gene": [
        {
          "benign_score": 0,
          "criteria": [],
          "effects": [
            "missense_variant"
          ],
          "gene_symbol": "TTN",
          "hgnc_id": 12403,
          "hgvs_c": "c.52009_52011delCGAinsTTG",
          "hgvs_p": "p.Arg17337Leu",
          "inheritance_mode": "AD,AR",
          "pathogenic_score": 0,
          "score": 0,
          "transcript": "NM_001267550.2",
          "verdict": "Uncertain_significance"
        },
        {
          "benign_score": 0,
          "criteria": [],
          "effects": [
            "intron_variant"
          ],
          "gene_symbol": "TTN-AS1",
          "hgnc_id": 44124,
          "hgvs_c": "n.749+1033_749+1035delTCGinsCAA",
          "hgvs_p": null,
          "inheritance_mode": "",
          "pathogenic_score": 0,
          "score": 0,
          "transcript": "ENST00000456053.5",
          "verdict": "Uncertain_significance"
        }
      ],
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "",
      "acmg_score": 0,
      "allele_count_reference_population": 0,
      "alphamissense_prediction": null,
      "alphamissense_score": null,
      "alt": "CAA",
      "apogee2_prediction": null,
      "apogee2_score": null,
      "bayesdelnoaf_prediction": null,
      "bayesdelnoaf_score": null,
      "chr": "2",
      "clinvar_classification": "",
      "clinvar_disease": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "computational_prediction_selected": null,
      "computational_score_selected": null,
      "computational_source_selected": null,
      "consequences": [
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 35991,
          "aa_ref": "R",
          "aa_start": 17337,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 109224,
          "cdna_start": 52236,
          "cds_end": null,
          "cds_length": 107976,
          "cds_start": 52009,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 363,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001267550.2",
          "gene_hgnc_id": 12403,
          "gene_symbol": "TTN",
          "hgvs_c": "c.52009_52011delCGAinsTTG",
          "hgvs_p": "p.Arg17337Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "ENST00000589042.5",
          "protein_coding": true,
          "protein_id": "NP_001254479.2",
          "strand": false,
          "transcript": "NM_001267550.2",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 35991,
          "aa_ref": "R",
          "aa_start": 17337,
          "biotype": "protein_coding",
          "canonical": true,
          "cdna_end": null,
          "cdna_length": 109224,
          "cdna_start": 52236,
          "cds_end": null,
          "cds_length": 107976,
          "cds_start": 52009,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 363,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000589042.5",
          "gene_hgnc_id": 12403,
          "gene_symbol": "TTN",
          "hgvs_c": "c.52009_52011delCGAinsTTG",
          "hgvs_p": "p.Arg17337Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": "NM_001267550.2",
          "protein_coding": true,
          "protein_id": "ENSP00000467141.1",
          "strand": false,
          "transcript": "ENST00000589042.5",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 35939,
          "aa_ref": "R",
          "aa_start": 17285,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 109068,
          "cdna_start": 52080,
          "cds_end": null,
          "cds_length": 107820,
          "cds_start": 51853,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 361,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000446966.2",
          "gene_hgnc_id": 12403,
          "gene_symbol": "TTN",
          "hgvs_c": "c.51853_51855delCGAinsTTG",
          "hgvs_p": "p.Arg17285Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000408004.2",
          "strand": false,
          "transcript": "ENST00000446966.2",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 35899,
          "aa_ref": "R",
          "aa_start": 17245,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 108948,
          "cdna_start": 51960,
          "cds_end": null,
          "cds_length": 107700,
          "cds_start": 51733,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 361,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000436599.2",
          "gene_hgnc_id": 12403,
          "gene_symbol": "TTN",
          "hgvs_c": "c.51733_51735delCGAinsTTG",
          "hgvs_p": "p.Arg17245Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000405517.2",
          "strand": false,
          "transcript": "ENST00000436599.2",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 35805,
          "aa_ref": "R",
          "aa_start": 17151,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 108666,
          "cdna_start": 51678,
          "cds_end": null,
          "cds_length": 107418,
          "cds_start": 51451,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 356,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000426232.6",
          "gene_hgnc_id": 12403,
          "gene_symbol": "TTN",
          "hgvs_c": "c.51451_51453delCGAinsTTG",
          "hgvs_p": "p.Arg17151Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000392336.2",
          "strand": false,
          "transcript": "ENST00000426232.6",
          "transcript_support_level": 1
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 35991,
          "aa_ref": "R",
          "aa_start": 17337,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 109488,
          "cdna_start": 52500,
          "cds_end": null,
          "cds_length": 107976,
          "cds_start": 52009,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 365,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000412264.2",
          "gene_hgnc_id": 12403,
          "gene_symbol": "TTN",
          "hgvs_c": "c.52009_52011delCGAinsTTG",
          "hgvs_p": "p.Arg17337Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000394672.2",
          "strand": false,
          "transcript": "ENST00000412264.2",
          "transcript_support_level": 3
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 35963,
          "aa_ref": "R",
          "aa_start": 17309,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 109140,
          "cdna_start": 52152,
          "cds_end": null,
          "cds_length": 107892,
          "cds_start": 51925,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 362,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000425332.3",
          "gene_hgnc_id": 12403,
          "gene_symbol": "TTN",
          "hgvs_c": "c.51925_51927delCGAinsTTG",
          "hgvs_p": "p.Arg17309Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000396805.3",
          "strand": false,
          "transcript": "ENST00000425332.3",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 35853,
          "aa_ref": "R",
          "aa_start": 17199,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 108810,
          "cdna_start": 51822,
          "cds_end": null,
          "cds_length": 107562,
          "cds_start": 51595,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 360,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000715174.1",
          "gene_hgnc_id": 12403,
          "gene_symbol": "TTN",
          "hgvs_c": "c.51595_51597delCGAinsTTG",
          "hgvs_p": "p.Arg17199Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000520370.1",
          "strand": false,
          "transcript": "ENST00000715174.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 34350,
          "aa_ref": "R",
          "aa_start": 15696,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 104301,
          "cdna_start": 47313,
          "cds_end": null,
          "cds_length": 103053,
          "cds_start": 47086,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 313,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_001256850.1",
          "gene_hgnc_id": 12403,
          "gene_symbol": "TTN",
          "hgvs_c": "c.47086_47088delCGAinsTTG",
          "hgvs_p": "p.Arg15696Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_001243779.1",
          "strand": false,
          "transcript": "NM_001256850.1",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 34350,
          "aa_ref": "R",
          "aa_start": 15696,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 104301,
          "cdna_start": 47313,
          "cds_end": null,
          "cds_length": 103053,
          "cds_start": 47086,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 313,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000591111.5",
          "gene_hgnc_id": 12403,
          "gene_symbol": "TTN",
          "hgvs_c": "c.47086_47088delCGAinsTTG",
          "hgvs_p": "p.Arg15696Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000465570.1",
          "strand": false,
          "transcript": "ENST00000591111.5",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 33423,
          "aa_ref": "R",
          "aa_start": 14769,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 101520,
          "cdna_start": 44532,
          "cds_end": null,
          "cds_length": 100272,
          "cds_start": 44305,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 312,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_133378.4",
          "gene_hgnc_id": 12403,
          "gene_symbol": "TTN",
          "hgvs_c": "c.44305_44307delCGAinsTTG",
          "hgvs_p": "p.Arg14769Leu",
          "intron_rank": null,
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          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_596869.4",
          "strand": false,
          "transcript": "NM_133378.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
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          "aa_length": 33423,
          "aa_ref": "R",
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          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 101520,
          "cdna_start": 44532,
          "cds_end": null,
          "cds_length": 100272,
          "cds_start": 44305,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 312,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000342992.11",
          "gene_hgnc_id": 12403,
          "gene_symbol": "TTN",
          "hgvs_c": "c.44305_44307delCGAinsTTG",
          "hgvs_p": "p.Arg14769Leu",
          "intron_rank": null,
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          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000343764.6",
          "strand": false,
          "transcript": "ENST00000342992.11",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "L",
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          "aa_length": 27118,
          "aa_ref": "R",
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          "biotype": "protein_coding",
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          "cdna_start": 25617,
          "cds_end": null,
          "cds_length": 81357,
          "cds_start": 25390,
          "consequences": [
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          ],
          "exon_count": 192,
          "exon_rank": null,
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          "feature": "NM_133437.4",
          "gene_hgnc_id": 12403,
          "gene_symbol": "TTN",
          "hgvs_c": "c.25390_25392delCGAinsTTG",
          "hgvs_p": "p.Arg8464Leu",
          "intron_rank": null,
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          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_597681.4",
          "strand": false,
          "transcript": "NM_133437.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 27118,
          "aa_ref": "R",
          "aa_start": 8464,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 82380,
          "cdna_start": 25392,
          "cds_end": null,
          "cds_length": 81357,
          "cds_start": 25390,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 191,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000342175.12",
          "gene_hgnc_id": 12403,
          "gene_symbol": "TTN",
          "hgvs_c": "c.25390_25392delCGAinsTTG",
          "hgvs_p": "p.Arg8464Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000340554.6",
          "strand": false,
          "transcript": "ENST00000342175.12",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 27051,
          "aa_ref": "R",
          "aa_start": 8397,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 82404,
          "cdna_start": 25416,
          "cds_end": null,
          "cds_length": 81156,
          "cds_start": 25189,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 192,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_133432.3",
          "gene_hgnc_id": 12403,
          "gene_symbol": "TTN",
          "hgvs_c": "c.25189_25191delCGAinsTTG",
          "hgvs_p": "p.Arg8397Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_597676.3",
          "strand": false,
          "transcript": "NM_133432.3",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
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          "aa_length": 27051,
          "aa_ref": "R",
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          "biotype": "protein_coding",
          "canonical": false,
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          "cdna_length": 82179,
          "cdna_start": 25191,
          "cds_end": null,
          "cds_length": 81156,
          "cds_start": 25189,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 191,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000359218.11",
          "gene_hgnc_id": 12403,
          "gene_symbol": "TTN",
          "hgvs_c": "c.25189_25191delCGAinsTTG",
          "hgvs_p": "p.Arg8397Leu",
          "intron_rank": null,
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          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000352154.5",
          "strand": false,
          "transcript": "ENST00000359218.11",
          "transcript_support_level": 5
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 26926,
          "aa_ref": "R",
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          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 82029,
          "cdna_start": 25041,
          "cds_end": null,
          "cds_length": 80781,
          "cds_start": 24814,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 191,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "NM_003319.4",
          "gene_hgnc_id": 12403,
          "gene_symbol": "TTN",
          "hgvs_c": "c.24814_24816delCGAinsTTG",
          "hgvs_p": "p.Arg8272Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "NP_003310.4",
          "strand": false,
          "transcript": "NM_003319.4",
          "transcript_support_level": null
        },
        {
          "aa_alt": "L",
          "aa_end": null,
          "aa_length": 26926,
          "aa_ref": "R",
          "aa_start": 8272,
          "biotype": "protein_coding",
          "canonical": false,
          "cdna_end": null,
          "cdna_length": 82029,
          "cdna_start": 25041,
          "cds_end": null,
          "cds_length": 80781,
          "cds_start": 24814,
          "consequences": [
            "missense_variant"
          ],
          "exon_count": 191,
          "exon_rank": null,
          "exon_rank_end": null,
          "feature": "ENST00000460472.6",
          "gene_hgnc_id": 12403,
          "gene_symbol": "TTN",
          "hgvs_c": "c.24814_24816delCGAinsTTG",
          "hgvs_p": "p.Arg8272Leu",
          "intron_rank": null,
          "intron_rank_end": null,
          "mane_plus": null,
          "mane_select": null,
          "protein_coding": true,
          "protein_id": "ENSP00000434586.1",
          "strand": false,
          "transcript": "ENST00000460472.6",
          "transcript_support_level": 5
        },
        {
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For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.