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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-179115076-T-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=179115076&ref=T&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "2",
      "pos": 179115076,
      "ref": "T",
      "alt": "C",
      "effect": "missense_variant",
      "transcript": "NM_178123.5",
      "consequences": [
        {
          "aa_ref": "N",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SESTD1",
          "gene_hgnc_id": 18379,
          "hgvs_c": "c.1828A>G",
          "hgvs_p": "p.Asn610Asp",
          "transcript": "NM_178123.5",
          "protein_id": "NP_835224.3",
          "transcript_support_level": null,
          "aa_start": 610,
          "aa_end": null,
          "aa_length": 696,
          "cds_start": 1828,
          "cds_end": null,
          "cds_length": 2091,
          "cdna_start": 2187,
          "cdna_end": null,
          "cdna_length": 10671,
          "mane_select": "ENST00000428443.8",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_178123.5"
        },
        {
          "aa_ref": "N",
          "aa_alt": "D",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SESTD1",
          "gene_hgnc_id": 18379,
          "hgvs_c": "c.1828A>G",
          "hgvs_p": "p.Asn610Asp",
          "transcript": "ENST00000428443.8",
          "protein_id": "ENSP00000415332.2",
          "transcript_support_level": 1,
          "aa_start": 610,
          "aa_end": null,
          "aa_length": 696,
          "cds_start": 1828,
          "cds_end": null,
          "cds_length": 2091,
          "cdna_start": 2187,
          "cdna_end": null,
          "cdna_length": 10671,
          "mane_select": "NM_178123.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000428443.8"
        },
        {
          "aa_ref": "N",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SESTD1",
          "gene_hgnc_id": 18379,
          "hgvs_c": "c.1843A>G",
          "hgvs_p": "p.Asn615Asp",
          "transcript": "ENST00000949563.1",
          "protein_id": "ENSP00000619622.1",
          "transcript_support_level": null,
          "aa_start": 615,
          "aa_end": null,
          "aa_length": 701,
          "cds_start": 1843,
          "cds_end": null,
          "cds_length": 2106,
          "cdna_start": 2167,
          "cdna_end": null,
          "cdna_length": 3029,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000949563.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SESTD1",
          "gene_hgnc_id": 18379,
          "hgvs_c": "c.1828A>G",
          "hgvs_p": "p.Asn610Asp",
          "transcript": "ENST00000854639.1",
          "protein_id": "ENSP00000524698.1",
          "transcript_support_level": null,
          "aa_start": 610,
          "aa_end": null,
          "aa_length": 696,
          "cds_start": 1828,
          "cds_end": null,
          "cds_length": 2091,
          "cdna_start": 2077,
          "cdna_end": null,
          "cdna_length": 2692,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000854639.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SESTD1",
          "gene_hgnc_id": 18379,
          "hgvs_c": "c.1828A>G",
          "hgvs_p": "p.Asn610Asp",
          "transcript": "ENST00000854640.1",
          "protein_id": "ENSP00000524699.1",
          "transcript_support_level": null,
          "aa_start": 610,
          "aa_end": null,
          "aa_length": 696,
          "cds_start": 1828,
          "cds_end": null,
          "cds_length": 2091,
          "cdna_start": 2115,
          "cdna_end": null,
          "cdna_length": 2730,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000854640.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SESTD1",
          "gene_hgnc_id": 18379,
          "hgvs_c": "c.1828A>G",
          "hgvs_p": "p.Asn610Asp",
          "transcript": "ENST00000949562.1",
          "protein_id": "ENSP00000619621.1",
          "transcript_support_level": null,
          "aa_start": 610,
          "aa_end": null,
          "aa_length": 696,
          "cds_start": 1828,
          "cds_end": null,
          "cds_length": 2091,
          "cdna_start": 2176,
          "cdna_end": null,
          "cdna_length": 3536,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000949562.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 19,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SESTD1",
          "gene_hgnc_id": 18379,
          "hgvs_c": "c.1828A>G",
          "hgvs_p": "p.Asn610Asp",
          "transcript": "ENST00000949565.1",
          "protein_id": "ENSP00000619624.1",
          "transcript_support_level": null,
          "aa_start": 610,
          "aa_end": null,
          "aa_length": 696,
          "cds_start": 1828,
          "cds_end": null,
          "cds_length": 2091,
          "cdna_start": 1935,
          "cdna_end": null,
          "cdna_length": 2966,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000949565.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SESTD1",
          "gene_hgnc_id": 18379,
          "hgvs_c": "c.1828A>G",
          "hgvs_p": "p.Asn610Asp",
          "transcript": "ENST00000949566.1",
          "protein_id": "ENSP00000619625.1",
          "transcript_support_level": null,
          "aa_start": 610,
          "aa_end": null,
          "aa_length": 696,
          "cds_start": 1828,
          "cds_end": null,
          "cds_length": 2091,
          "cdna_start": 2267,
          "cdna_end": null,
          "cdna_length": 3125,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000949566.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SESTD1",
          "gene_hgnc_id": 18379,
          "hgvs_c": "c.1828A>G",
          "hgvs_p": "p.Asn610Asp",
          "transcript": "ENST00000949567.1",
          "protein_id": "ENSP00000619626.1",
          "transcript_support_level": null,
          "aa_start": 610,
          "aa_end": null,
          "aa_length": 696,
          "cds_start": 1828,
          "cds_end": null,
          "cds_length": 2091,
          "cdna_start": 2010,
          "cdna_end": null,
          "cdna_length": 3369,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000949567.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "D",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SESTD1",
          "gene_hgnc_id": 18379,
          "hgvs_c": "c.1819A>G",
          "hgvs_p": "p.Asn607Asp",
          "transcript": "ENST00000854636.1",
          "protein_id": "ENSP00000524695.1",
          "transcript_support_level": null,
          "aa_start": 607,
          "aa_end": null,
          "aa_length": 693,
          "cds_start": 1819,
          "cds_end": null,
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          "cdna_start": 2140,
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          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "N",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SESTD1",
          "gene_hgnc_id": 18379,
          "hgvs_c": "c.1717A>G",
          "hgvs_p": "p.Asn573Asp",
          "transcript": "ENST00000949561.1",
          "protein_id": "ENSP00000619620.1",
          "transcript_support_level": null,
          "aa_start": 573,
          "aa_end": null,
          "aa_length": 659,
          "cds_start": 1717,
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          "cds_length": 1980,
          "cdna_start": 2030,
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          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "N",
          "aa_alt": "D",
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          "strand": false,
          "consequences": [
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          "intron_rank": null,
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          "gene_symbol": "SESTD1",
          "gene_hgnc_id": 18379,
          "hgvs_c": "c.1714A>G",
          "hgvs_p": "p.Asn572Asp",
          "transcript": "ENST00000949564.1",
          "protein_id": "ENSP00000619623.1",
          "transcript_support_level": null,
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          "cds_start": 1714,
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          "cdna_start": 2027,
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          "cdna_length": 2884,
          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "N",
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          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
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          "exon_count": 17,
          "intron_rank": null,
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          "gene_symbol": "SESTD1",
          "gene_hgnc_id": 18379,
          "hgvs_c": "c.1705A>G",
          "hgvs_p": "p.Asn569Asp",
          "transcript": "ENST00000854635.1",
          "protein_id": "ENSP00000524694.1",
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          "cds_start": 1705,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000854635.1"
        },
        {
          "aa_ref": "N",
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          "canonical": false,
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          "strand": false,
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          ],
          "exon_rank": 15,
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          "exon_count": 17,
          "intron_rank": null,
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          "gene_symbol": "SESTD1",
          "gene_hgnc_id": 18379,
          "hgvs_c": "c.1636A>G",
          "hgvs_p": "p.Asn546Asp",
          "transcript": "ENST00000854638.1",
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        {
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          "intron_rank": null,
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          "gene_symbol": "SESTD1",
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          "hgvs_c": "c.1594A>G",
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          "transcript": "ENST00000932265.1",
          "protein_id": "ENSP00000602324.1",
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          "cds_start": 1594,
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          "cdna_length": 2549,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000932265.1"
        },
        {
          "aa_ref": "N",
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          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 16,
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          "exon_count": 18,
          "intron_rank": null,
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          "gene_symbol": "SESTD1",
          "gene_hgnc_id": 18379,
          "hgvs_c": "c.1858A>G",
          "hgvs_p": "p.Asn620Asp",
          "transcript": "XM_047446273.1",
          "protein_id": "XP_047302229.1",
          "transcript_support_level": null,
          "aa_start": 620,
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          "cdna_start": 1991,
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        {
          "aa_ref": "N",
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          ],
          "exon_rank": 15,
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          "intron_rank": null,
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          "gene_symbol": "SESTD1",
          "gene_hgnc_id": 18379,
          "hgvs_c": "c.1735A>G",
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          "transcript": "XM_047446274.1",
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        {
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          "intron_rank": null,
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          "gene_symbol": "SESTD1",
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          "hgvs_c": "c.1582A>G",
          "hgvs_p": "p.Asn528Asp",
          "transcript": "XM_011512141.3",
          "protein_id": "XP_011510443.1",
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        },
        {
          "aa_ref": "N",
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          "strand": false,
          "consequences": [
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          ],
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          "intron_rank": null,
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          "gene_symbol": "SESTD1",
          "gene_hgnc_id": 18379,
          "hgvs_c": "c.1369A>G",
          "hgvs_p": "p.Asn457Asp",
          "transcript": "XM_047446275.1",
          "protein_id": "XP_047302231.1",
          "transcript_support_level": null,
          "aa_start": 457,
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          "cds_start": 1369,
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          "cdna_start": 1787,
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          "cdna_length": 10271,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047446275.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": 16,
          "intron_rank_end": null,
          "gene_symbol": "SESTD1",
          "gene_hgnc_id": 18379,
          "hgvs_c": "c.1755+73A>G",
          "hgvs_p": null,
          "transcript": "ENST00000854637.1",
          "protein_id": "ENSP00000524696.1",
          "transcript_support_level": null,
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          "aa_length": 668,
          "cds_start": null,
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          "cdna_start": null,
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          "cdna_length": 2680,
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          "biotype": "protein_coding",
          "feature": "ENST00000854637.1"
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        {
          "aa_ref": null,
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          "protein_coding": false,
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          "consequences": [
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          "exon_count": 10,
          "intron_rank": null,
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          "transcript": "ENST00000335289.5",
          "protein_id": "ENSP00000334183.5",
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          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 1675,
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          "biotype": "nonsense_mediated_decay",
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        {
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          "protein_coding": false,
          "strand": false,
          "consequences": [
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          "exon_count": 8,
          "intron_rank": null,
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          "gene_symbol": "SESTD1",
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          "hgvs_c": "n.*227A>G",
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          "transcript": "ENST00000446758.5",
          "protein_id": "ENSP00000410632.1",
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          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
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          "cdna_length": 1699,
          "mane_select": null,
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          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000446758.5"
        },
        {
          "aa_ref": null,
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          "canonical": false,
          "protein_coding": false,
          "strand": false,
          "consequences": [
            "3_prime_UTR_variant"
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          "exon_rank": 8,
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          "exon_count": 10,
          "intron_rank": null,
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          "gene_symbol": "SESTD1",
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          "hgvs_c": "n.*545A>G",
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          "transcript": "ENST00000335289.5",
          "protein_id": "ENSP00000334183.5",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
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          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
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          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000335289.5"
        },
        {
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          "protein_coding": false,
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          "consequences": [
            "3_prime_UTR_variant"
          ],
          "exon_rank": 6,
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          "exon_count": 8,
          "intron_rank": null,
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          "gene_symbol": "SESTD1",
          "gene_hgnc_id": 18379,
          "hgvs_c": "n.*227A>G",
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          "transcript": "ENST00000446758.5",
          "protein_id": "ENSP00000410632.1",
          "transcript_support_level": 2,
          "aa_start": null,
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          "cds_start": null,
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          "cds_length": null,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 1699,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "nonsense_mediated_decay",
          "feature": "ENST00000446758.5"
        }
      ],
      "gene_symbol": "SESTD1",
      "gene_hgnc_id": 18379,
      "dbsnp": "rs1429981035",
      "frequency_reference_population": 0.000008695318,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 14,
      "gnomad_exomes_af": 0.0000041156,
      "gnomad_genomes_af": 0.0000525638,
      "gnomad_exomes_ac": 6,
      "gnomad_genomes_ac": 8,
      "gnomad_exomes_homalt": 0,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.12268230319023132,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.066,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.0952,
      "alphamissense_prediction": "Benign",
      "bayesdelnoaf_score": -0.63,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 5.422,
      "phylop100way_prediction": "Uncertain_significance",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": -6,
      "acmg_classification": "Likely_benign",
      "acmg_criteria": "BP4_Moderate,BS2",
      "acmg_by_gene": [
        {
          "score": -6,
          "benign_score": 6,
          "pathogenic_score": 0,
          "criteria": [
            "BP4_Moderate",
            "BS2"
          ],
          "verdict": "Likely_benign",
          "transcript": "NM_178123.5",
          "gene_symbol": "SESTD1",
          "hgnc_id": 18379,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AD",
          "hgvs_c": "c.1828A>G",
          "hgvs_p": "p.Asn610Asp"
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.