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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-187380718-A-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=187380718&ref=A&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 187380718,
"ref": "A",
"alt": "G",
"effect": "missense_variant",
"transcript": "NM_005795.6",
"consequences": [
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "NM_005795.6",
"protein_id": "NP_005786.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 760,
"cdna_end": null,
"cdna_length": 6112,
"mane_select": "ENST00000392370.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_005795.6"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "ENST00000392370.8",
"protein_id": "ENSP00000376177.3",
"transcript_support_level": 1,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 760,
"cdna_end": null,
"cdna_length": 6112,
"mane_select": "NM_005795.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000392370.8"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "NM_001271751.2",
"protein_id": "NP_001258680.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 595,
"cdna_end": null,
"cdna_length": 5947,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001271751.2"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "NM_001369434.1",
"protein_id": "NP_001356363.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 828,
"cdna_end": null,
"cdna_length": 6180,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001369434.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "NM_001369435.1",
"protein_id": "NP_001356364.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 722,
"cdna_end": null,
"cdna_length": 6074,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001369435.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "ENST00000409998.5",
"protein_id": "ENSP00000386972.1",
"transcript_support_level": 5,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 1036,
"cdna_end": null,
"cdna_length": 5223,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000409998.5"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "ENST00000410068.5",
"protein_id": "ENSP00000387190.1",
"transcript_support_level": 2,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 595,
"cdna_end": null,
"cdna_length": 1984,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000410068.5"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "ENST00000897822.1",
"protein_id": "ENSP00000567881.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 2466,
"cdna_end": null,
"cdna_length": 7822,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897822.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "ENST00000897823.1",
"protein_id": "ENSP00000567882.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 899,
"cdna_end": null,
"cdna_length": 4922,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897823.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "ENST00000897824.1",
"protein_id": "ENSP00000567883.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 675,
"cdna_end": null,
"cdna_length": 4697,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897824.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "ENST00000897825.1",
"protein_id": "ENSP00000567884.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 804,
"cdna_end": null,
"cdna_length": 4824,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897825.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "ENST00000897826.1",
"protein_id": "ENSP00000567885.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 1039,
"cdna_end": null,
"cdna_length": 4394,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897826.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "ENST00000897827.1",
"protein_id": "ENSP00000567886.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 851,
"cdna_end": null,
"cdna_length": 4204,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897827.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "ENST00000897828.1",
"protein_id": "ENSP00000567887.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 975,
"cdna_end": null,
"cdna_length": 4327,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897828.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "ENST00000897830.1",
"protein_id": "ENSP00000567889.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 859,
"cdna_end": null,
"cdna_length": 3629,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897830.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "ENST00000897831.1",
"protein_id": "ENSP00000567890.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 754,
"cdna_end": null,
"cdna_length": 2964,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897831.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "ENST00000897832.1",
"protein_id": "ENSP00000567891.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 838,
"cdna_end": null,
"cdna_length": 3048,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897832.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "ENST00000897833.1",
"protein_id": "ENSP00000567892.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 897,
"cdna_end": null,
"cdna_length": 3035,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897833.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "ENST00000897834.1",
"protein_id": "ENSP00000567893.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 935,
"cdna_end": null,
"cdna_length": 2288,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897834.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "ENST00000897835.1",
"protein_id": "ENSP00000567894.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 727,
"cdna_end": null,
"cdna_length": 3298,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897835.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "ENST00000897836.1",
"protein_id": "ENSP00000567895.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 857,
"cdna_end": null,
"cdna_length": 3069,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000897836.1"
},
{
"aa_ref": "M",
"aa_alt": "T",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CALCRL",
"gene_hgnc_id": 16709,
"hgvs_c": "c.254T>C",
"hgvs_p": "p.Met85Thr",
"transcript": "ENST00000969621.1",
"protein_id": "ENSP00000639680.1",
"transcript_support_level": null,
"aa_start": 85,
"aa_end": null,
"aa_length": 461,
"cds_start": 254,
"cds_end": null,
"cds_length": 1386,
"cdna_start": 754,
"cdna_end": null,
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"phenotype_combined": "not specified",
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}
],
"message": null
}