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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-200389448-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=200389448&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 200389448,
"ref": "A",
"alt": "T",
"effect": "intron_variant",
"transcript": "NM_001100423.2",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPATS2L",
"gene_hgnc_id": 24574,
"hgvs_c": "n.481A>T",
"hgvs_p": null,
"transcript": "ENST00000459656.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1901,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SPATS2L",
"gene_hgnc_id": 24574,
"hgvs_c": "c.39+165A>T",
"hgvs_p": null,
"transcript": "NM_001100423.2",
"protein_id": "NP_001093893.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 558,
"cds_start": -4,
"cds_end": null,
"cds_length": 1677,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6212,
"mane_select": "ENST00000409140.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SPATS2L",
"gene_hgnc_id": 24574,
"hgvs_c": "c.39+165A>T",
"hgvs_p": null,
"transcript": "ENST00000409140.8",
"protein_id": "ENSP00000386730.3",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 558,
"cds_start": -4,
"cds_end": null,
"cds_length": 1677,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6212,
"mane_select": "NM_001100423.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SPATS2L",
"gene_hgnc_id": 24574,
"hgvs_c": "c.39+165A>T",
"hgvs_p": null,
"transcript": "ENST00000358677.9",
"protein_id": "ENSP00000351503.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 558,
"cds_start": -4,
"cds_end": null,
"cds_length": 1677,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6156,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SPATS2L",
"gene_hgnc_id": 24574,
"hgvs_c": "c.39+165A>T",
"hgvs_p": null,
"transcript": "ENST00000360760.9",
"protein_id": "ENSP00000353989.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 489,
"cds_start": -4,
"cds_end": null,
"cds_length": 1470,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2119,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "SPATS2L",
"gene_hgnc_id": 24574,
"hgvs_c": "n.324A>T",
"hgvs_p": null,
"transcript": "ENST00000471601.5",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1730,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SPATS2L",
"gene_hgnc_id": 24574,
"hgvs_c": "c.129+165A>T",
"hgvs_p": null,
"transcript": "NM_001282744.2",
"protein_id": "NP_001269673.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 588,
"cds_start": -4,
"cds_end": null,
"cds_length": 1767,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6123,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SPATS2L",
"gene_hgnc_id": 24574,
"hgvs_c": "c.129+165A>T",
"hgvs_p": null,
"transcript": "ENST00000619961.4",
"protein_id": "ENSP00000482515.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 588,
"cds_start": -4,
"cds_end": null,
"cds_length": 1767,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6115,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SPATS2L",
"gene_hgnc_id": 24574,
"hgvs_c": "c.63+165A>T",
"hgvs_p": null,
"transcript": "ENST00000409151.5",
"protein_id": "ENSP00000386310.1",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 566,
"cds_start": -4,
"cds_end": null,
"cds_length": 1701,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1979,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SPATS2L",
"gene_hgnc_id": 24574,
"hgvs_c": "c.39+165A>T",
"hgvs_p": null,
"transcript": "NM_001100422.1",
"protein_id": "NP_001093892.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 558,
"cds_start": -4,
"cds_end": null,
"cds_length": 1677,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 6321,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SPATS2L",
"gene_hgnc_id": 24574,
"hgvs_c": "c.39+165A>T",
"hgvs_p": null,
"transcript": "NM_001282735.1",
"protein_id": "NP_001269664.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 558,
"cds_start": -4,
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"cdna_start": null,
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"cdna_length": 6393,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SPATS2L",
"gene_hgnc_id": 24574,
"hgvs_c": "c.39+165A>T",
"hgvs_p": null,
"transcript": "NM_015535.3",
"protein_id": "NP_056350.2",
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"aa_start": null,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SPATS2L",
"gene_hgnc_id": 24574,
"hgvs_c": "c.39+165A>T",
"hgvs_p": null,
"transcript": "ENST00000409718.5",
"protein_id": "ENSP00000386336.1",
"transcript_support_level": 2,
"aa_start": null,
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"cds_start": -4,
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"cdna_start": null,
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},
{
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"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 13,
"intron_rank": 3,
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"gene_symbol": "SPATS2L",
"gene_hgnc_id": 24574,
"hgvs_c": "c.39+165A>T",
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"transcript": "ENST00000409988.7",
"protein_id": "ENSP00000386931.3",
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},
{
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],
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"intron_rank": 4,
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"gene_symbol": "SPATS2L",
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"hgvs_c": "c.39+165A>T",
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"transcript": "ENST00000451764.6",
"protein_id": "ENSP00000391467.2",
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"mane_select": null,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 2,
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"gene_symbol": "SPATS2L",
"gene_hgnc_id": 24574,
"hgvs_c": "c.-141-22863A>T",
"hgvs_p": null,
"transcript": "NM_001282743.1",
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},
{
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],
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"intron_rank": 2,
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"gene_symbol": "SPATS2L",
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"hgvs_c": "c.-141-22863A>T",
"hgvs_p": null,
"transcript": "ENST00000409385.5",
"protein_id": "ENSP00000386391.1",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
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],
"exon_rank": null,
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"exon_count": 12,
"intron_rank": 3,
"intron_rank_end": null,
"gene_symbol": "SPATS2L",
"gene_hgnc_id": 24574,
"hgvs_c": "c.39+165A>T",
"hgvs_p": null,
"transcript": "NM_001100424.1",
"protein_id": "NP_001093894.1",
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},
{
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"protein_coding": true,
"strand": true,
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],
"exon_rank": null,
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"exon_count": 10,
"intron_rank": 3,
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"gene_symbol": "SPATS2L",
"gene_hgnc_id": 24574,
"hgvs_c": "c.39+165A>T",
"hgvs_p": null,
"transcript": "ENST00000409397.6",
"protein_id": "ENSP00000386600.2",
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},
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],
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"gene_symbol": "SPATS2L",
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"hgvs_c": "c.39+165A>T",
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},
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],
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"gene_symbol": "SPATS2L",
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},
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"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SPATS2L",
"gene_hgnc_id": 24574,
"hgvs_c": "c.39+165A>T",
"hgvs_p": null,
"transcript": "ENST00000449647.5",
"protein_id": "ENSP00000413142.1",
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"cds_start": -4,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "SPATS2L",
"gene_hgnc_id": 24574,
"hgvs_c": "c.39+165A>T",
"hgvs_p": null,
"transcript": "ENST00000421573.5",
"protein_id": "ENSP00000402559.1",
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"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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