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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-201160539-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=201160539&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 201160539,
"ref": "G",
"alt": "T",
"effect": "stop_gained",
"transcript": "NM_003879.7",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.901G>T",
"hgvs_p": "p.Glu301*",
"transcript": "NM_003879.7",
"protein_id": "NP_003870.4",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 480,
"cds_start": 901,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1356,
"cdna_end": null,
"cdna_length": 14612,
"mane_select": "ENST00000309955.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_003879.7"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.901G>T",
"hgvs_p": "p.Glu301*",
"transcript": "ENST00000309955.8",
"protein_id": "ENSP00000312455.2",
"transcript_support_level": 1,
"aa_start": 301,
"aa_end": null,
"aa_length": 480,
"cds_start": 901,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1356,
"cdna_end": null,
"cdna_length": 14612,
"mane_select": "NM_003879.7",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000309955.8"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.901G>T",
"hgvs_p": "p.Glu301*",
"transcript": "ENST00000423241.6",
"protein_id": "ENSP00000399420.2",
"transcript_support_level": 1,
"aa_start": 301,
"aa_end": null,
"aa_length": 480,
"cds_start": 901,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1449,
"cdna_end": null,
"cdna_length": 2128,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000423241.6"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.901G>T",
"hgvs_p": "p.Glu301*",
"transcript": "ENST00000457277.5",
"protein_id": "ENSP00000411535.1",
"transcript_support_level": 1,
"aa_start": 301,
"aa_end": null,
"aa_length": 462,
"cds_start": 901,
"cds_end": null,
"cds_length": 1389,
"cdna_start": 901,
"cdna_end": null,
"cdna_length": 1868,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000457277.5"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.796G>T",
"hgvs_p": "p.Glu266*",
"transcript": "ENST00000341582.10",
"protein_id": "ENSP00000345807.6",
"transcript_support_level": 1,
"aa_start": 266,
"aa_end": null,
"aa_length": 445,
"cds_start": 796,
"cds_end": null,
"cds_length": 1338,
"cdna_start": 1208,
"cdna_end": null,
"cdna_length": 2056,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000341582.10"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "n.549G>T",
"hgvs_p": null,
"transcript": "ENST00000474842.1",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 1091,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000474842.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.1126G>T",
"hgvs_p": "p.Glu376*",
"transcript": "ENST00000890675.1",
"protein_id": "ENSP00000560734.1",
"transcript_support_level": null,
"aa_start": 376,
"aa_end": null,
"aa_length": 555,
"cds_start": 1126,
"cds_end": null,
"cds_length": 1668,
"cdna_start": 1343,
"cdna_end": null,
"cdna_length": 2205,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890675.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.1126G>T",
"hgvs_p": "p.Glu376*",
"transcript": "ENST00000948379.1",
"protein_id": "ENSP00000618438.1",
"transcript_support_level": null,
"aa_start": 376,
"aa_end": null,
"aa_length": 555,
"cds_start": 1126,
"cds_end": null,
"cds_length": 1668,
"cdna_start": 1374,
"cdna_end": null,
"cdna_length": 2219,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948379.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.994G>T",
"hgvs_p": "p.Glu332*",
"transcript": "ENST00000948374.1",
"protein_id": "ENSP00000618433.1",
"transcript_support_level": null,
"aa_start": 332,
"aa_end": null,
"aa_length": 511,
"cds_start": 994,
"cds_end": null,
"cds_length": 1536,
"cdna_start": 1369,
"cdna_end": null,
"cdna_length": 2214,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948374.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.991G>T",
"hgvs_p": "p.Glu331*",
"transcript": "ENST00000948375.1",
"protein_id": "ENSP00000618434.1",
"transcript_support_level": null,
"aa_start": 331,
"aa_end": null,
"aa_length": 510,
"cds_start": 991,
"cds_end": null,
"cds_length": 1533,
"cdna_start": 1200,
"cdna_end": null,
"cdna_length": 2044,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948375.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.901G>T",
"hgvs_p": "p.Glu301*",
"transcript": "NM_001127183.4",
"protein_id": "NP_001120655.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 480,
"cds_start": 901,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1224,
"cdna_end": null,
"cdna_length": 14480,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001127183.4"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.901G>T",
"hgvs_p": "p.Glu301*",
"transcript": "ENST00000890677.1",
"protein_id": "ENSP00000560736.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 480,
"cds_start": 901,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1160,
"cdna_end": null,
"cdna_length": 2022,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890677.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.901G>T",
"hgvs_p": "p.Glu301*",
"transcript": "ENST00000890678.1",
"protein_id": "ENSP00000560737.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 480,
"cds_start": 901,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1152,
"cdna_end": null,
"cdna_length": 1728,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890678.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.901G>T",
"hgvs_p": "p.Glu301*",
"transcript": "ENST00000890679.1",
"protein_id": "ENSP00000560738.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 480,
"cds_start": 901,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1130,
"cdna_end": null,
"cdna_length": 1815,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890679.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.901G>T",
"hgvs_p": "p.Glu301*",
"transcript": "ENST00000890681.1",
"protein_id": "ENSP00000560740.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 480,
"cds_start": 901,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1144,
"cdna_end": null,
"cdna_length": 2006,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890681.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.901G>T",
"hgvs_p": "p.Glu301*",
"transcript": "ENST00000948373.1",
"protein_id": "ENSP00000618432.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 480,
"cds_start": 901,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1828,
"cdna_end": null,
"cdna_length": 3498,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948373.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.901G>T",
"hgvs_p": "p.Glu301*",
"transcript": "ENST00000948376.1",
"protein_id": "ENSP00000618435.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 480,
"cds_start": 901,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1174,
"cdna_end": null,
"cdna_length": 1845,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948376.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.901G>T",
"hgvs_p": "p.Glu301*",
"transcript": "ENST00000948377.1",
"protein_id": "ENSP00000618436.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 480,
"cds_start": 901,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1176,
"cdna_end": null,
"cdna_length": 2107,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948377.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.901G>T",
"hgvs_p": "p.Glu301*",
"transcript": "ENST00000948380.1",
"protein_id": "ENSP00000618439.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 480,
"cds_start": 901,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1226,
"cdna_end": null,
"cdna_length": 2088,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948380.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.901G>T",
"hgvs_p": "p.Glu301*",
"transcript": "ENST00000948381.1",
"protein_id": "ENSP00000618440.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 480,
"cds_start": 901,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1189,
"cdna_end": null,
"cdna_length": 2066,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948381.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.901G>T",
"hgvs_p": "p.Glu301*",
"transcript": "ENST00000948382.1",
"protein_id": "ENSP00000618441.1",
"transcript_support_level": null,
"aa_start": 301,
"aa_end": null,
"aa_length": 480,
"cds_start": 901,
"cds_end": null,
"cds_length": 1443,
"cdna_start": 1238,
"cdna_end": null,
"cdna_length": 2084,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948382.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 9,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "CFLAR",
"gene_hgnc_id": 1876,
"hgvs_c": "c.898G>T",
"hgvs_p": "p.Glu300*",
"transcript": "ENST00000890673.1",
"protein_id": "ENSP00000560732.1",
"transcript_support_level": null,
"aa_start": 300,
"aa_end": null,
"aa_length": 479,
"cds_start": 898,
"cds_end": null,
"cds_length": 1440,
"cdna_start": 1338,
"cdna_end": null,
"cdna_length": 2200,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000890673.1"
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}
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}