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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-205763907-A-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=205763907&ref=A&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 205763907,
"ref": "A",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_201266.2",
"consequences": [
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "c.2278A>T",
"hgvs_p": "p.Ile760Phe",
"transcript": "NM_003872.3",
"protein_id": "NP_003863.2",
"transcript_support_level": null,
"aa_start": 760,
"aa_end": null,
"aa_length": 926,
"cds_start": 2278,
"cds_end": null,
"cds_length": 2781,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000357785.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_003872.3"
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "c.2278A>T",
"hgvs_p": "p.Ile760Phe",
"transcript": "ENST00000357785.10",
"protein_id": "ENSP00000350432.5",
"transcript_support_level": 1,
"aa_start": 760,
"aa_end": null,
"aa_length": 926,
"cds_start": 2278,
"cds_end": null,
"cds_length": 2781,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_003872.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000357785.10"
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "c.2278A>T",
"hgvs_p": "p.Ile760Phe",
"transcript": "ENST00000360409.7",
"protein_id": "ENSP00000353582.3",
"transcript_support_level": 1,
"aa_start": 760,
"aa_end": null,
"aa_length": 931,
"cds_start": 2278,
"cds_end": null,
"cds_length": 2796,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000360409.7"
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "c.2278A>T",
"hgvs_p": "p.Ile760Phe",
"transcript": "ENST00000412873.2",
"protein_id": "ENSP00000407626.2",
"transcript_support_level": 1,
"aa_start": 760,
"aa_end": null,
"aa_length": 909,
"cds_start": 2278,
"cds_end": null,
"cds_length": 2730,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000412873.2"
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "c.2278A>T",
"hgvs_p": "p.Ile760Phe",
"transcript": "ENST00000272849.7",
"protein_id": "ENSP00000272849.3",
"transcript_support_level": 1,
"aa_start": 760,
"aa_end": null,
"aa_length": 906,
"cds_start": 2278,
"cds_end": null,
"cds_length": 2721,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000272849.7"
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "c.2278A>T",
"hgvs_p": "p.Ile760Phe",
"transcript": "ENST00000357118.8",
"protein_id": "ENSP00000349632.4",
"transcript_support_level": 1,
"aa_start": 760,
"aa_end": null,
"aa_length": 901,
"cds_start": 2278,
"cds_end": null,
"cds_length": 2706,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000357118.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 4,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "n.173A>T",
"hgvs_p": null,
"transcript": "ENST00000485684.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000485684.5"
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "c.2278A>T",
"hgvs_p": "p.Ile760Phe",
"transcript": "NM_201266.2",
"protein_id": "NP_957718.1",
"transcript_support_level": null,
"aa_start": 760,
"aa_end": null,
"aa_length": 931,
"cds_start": 2278,
"cds_end": null,
"cds_length": 2796,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_201266.2"
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "c.2278A>T",
"hgvs_p": "p.Ile760Phe",
"transcript": "NM_201279.2",
"protein_id": "NP_958436.1",
"transcript_support_level": null,
"aa_start": 760,
"aa_end": null,
"aa_length": 909,
"cds_start": 2278,
"cds_end": null,
"cds_length": 2730,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_201279.2"
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "c.2278A>T",
"hgvs_p": "p.Ile760Phe",
"transcript": "NM_018534.4",
"protein_id": "NP_061004.3",
"transcript_support_level": null,
"aa_start": 760,
"aa_end": null,
"aa_length": 906,
"cds_start": 2278,
"cds_end": null,
"cds_length": 2721,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_018534.4"
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "c.2278A>T",
"hgvs_p": "p.Ile760Phe",
"transcript": "NM_201267.2",
"protein_id": "NP_957719.1",
"transcript_support_level": null,
"aa_start": 760,
"aa_end": null,
"aa_length": 901,
"cds_start": 2278,
"cds_end": null,
"cds_length": 2706,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_201267.2"
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "c.2278A>T",
"hgvs_p": "p.Ile760Phe",
"transcript": "XM_047446170.1",
"protein_id": "XP_047302126.1",
"transcript_support_level": null,
"aa_start": 760,
"aa_end": null,
"aa_length": 931,
"cds_start": 2278,
"cds_end": null,
"cds_length": 2796,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047446170.1"
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "c.2278A>T",
"hgvs_p": "p.Ile760Phe",
"transcript": "XM_047446171.1",
"protein_id": "XP_047302127.1",
"transcript_support_level": null,
"aa_start": 760,
"aa_end": null,
"aa_length": 931,
"cds_start": 2278,
"cds_end": null,
"cds_length": 2796,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047446171.1"
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "c.2278A>T",
"hgvs_p": "p.Ile760Phe",
"transcript": "XM_047446172.1",
"protein_id": "XP_047302128.1",
"transcript_support_level": null,
"aa_start": 760,
"aa_end": null,
"aa_length": 926,
"cds_start": 2278,
"cds_end": null,
"cds_length": 2781,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047446172.1"
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "c.2278A>T",
"hgvs_p": "p.Ile760Phe",
"transcript": "XM_047446173.1",
"protein_id": "XP_047302129.1",
"transcript_support_level": null,
"aa_start": 760,
"aa_end": null,
"aa_length": 926,
"cds_start": 2278,
"cds_end": null,
"cds_length": 2781,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047446173.1"
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "c.2278A>T",
"hgvs_p": "p.Ile760Phe",
"transcript": "XM_047446174.1",
"protein_id": "XP_047302130.1",
"transcript_support_level": null,
"aa_start": 760,
"aa_end": null,
"aa_length": 906,
"cds_start": 2278,
"cds_end": null,
"cds_length": 2721,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047446174.1"
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "c.2278A>T",
"hgvs_p": "p.Ile760Phe",
"transcript": "XM_047446175.1",
"protein_id": "XP_047302131.1",
"transcript_support_level": null,
"aa_start": 760,
"aa_end": null,
"aa_length": 901,
"cds_start": 2278,
"cds_end": null,
"cds_length": 2706,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047446175.1"
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "c.2278A>T",
"hgvs_p": "p.Ile760Phe",
"transcript": "XM_047446176.1",
"protein_id": "XP_047302132.1",
"transcript_support_level": null,
"aa_start": 760,
"aa_end": null,
"aa_length": 901,
"cds_start": 2278,
"cds_end": null,
"cds_length": 2706,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_047446176.1"
},
{
"aa_ref": "I",
"aa_alt": "F",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "c.2278A>T",
"hgvs_p": "p.Ile760Phe",
"transcript": "XM_017005188.3",
"protein_id": "XP_016860677.1",
"transcript_support_level": null,
"aa_start": 760,
"aa_end": null,
"aa_length": 848,
"cds_start": 2278,
"cds_end": null,
"cds_length": 2547,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "XM_017005188.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2-AS1",
"gene_hgnc_id": 40415,
"hgvs_c": "n.100T>A",
"hgvs_p": null,
"transcript": "ENST00000423425.3",
"protein_id": null,
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000423425.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2",
"gene_hgnc_id": 8005,
"hgvs_c": "n.107A>T",
"hgvs_p": null,
"transcript": "ENST00000472299.5",
"protein_id": null,
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "retained_intron",
"feature": "ENST00000472299.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 3,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NRP2-AS1",
"gene_hgnc_id": 40415,
"hgvs_c": "n.47T>A",
"hgvs_p": null,
"transcript": "ENST00000596616.3",
"protein_id": null,
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
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}
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}