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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-208326375-T-G (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=208326375&ref=T&alt=G&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "2",
      "pos": 208326375,
      "ref": "T",
      "alt": "G",
      "effect": "missense_variant",
      "transcript": "NM_015040.4",
      "consequences": [
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 42,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.3564T>G",
          "hgvs_p": "p.Asn1188Lys",
          "transcript": "NM_015040.4",
          "protein_id": "NP_055855.2",
          "transcript_support_level": null,
          "aa_start": 1188,
          "aa_end": null,
          "aa_length": 2098,
          "cds_start": 3564,
          "cds_end": null,
          "cds_length": 6297,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000264380.9",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_015040.4"
        },
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 42,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.3564T>G",
          "hgvs_p": "p.Asn1188Lys",
          "transcript": "ENST00000264380.9",
          "protein_id": "ENSP00000264380.4",
          "transcript_support_level": 1,
          "aa_start": 1188,
          "aa_end": null,
          "aa_length": 2098,
          "cds_start": 3564,
          "cds_end": null,
          "cds_length": 6297,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_015040.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000264380.9"
        },
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 43,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.3579T>G",
          "hgvs_p": "p.Asn1193Lys",
          "transcript": "ENST00000909798.1",
          "protein_id": "ENSP00000579857.1",
          "transcript_support_level": null,
          "aa_start": 1193,
          "aa_end": null,
          "aa_length": 2103,
          "cds_start": 3579,
          "cds_end": null,
          "cds_length": 6312,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000909798.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 42,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.3546T>G",
          "hgvs_p": "p.Asn1182Lys",
          "transcript": "ENST00000923116.1",
          "protein_id": "ENSP00000593175.1",
          "transcript_support_level": null,
          "aa_start": 1182,
          "aa_end": null,
          "aa_length": 2092,
          "cds_start": 3546,
          "cds_end": null,
          "cds_length": 6279,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000923116.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 41,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.3378T>G",
          "hgvs_p": "p.Asn1126Lys",
          "transcript": "ENST00000923111.1",
          "protein_id": "ENSP00000593170.1",
          "transcript_support_level": null,
          "aa_start": 1126,
          "aa_end": null,
          "aa_length": 2036,
          "cds_start": 3378,
          "cds_end": null,
          "cds_length": 6111,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000923111.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.3273T>G",
          "hgvs_p": "p.Asn1091Lys",
          "transcript": "ENST00000923110.1",
          "protein_id": "ENSP00000593169.1",
          "transcript_support_level": null,
          "aa_start": 1091,
          "aa_end": null,
          "aa_length": 2001,
          "cds_start": 3273,
          "cds_end": null,
          "cds_length": 6006,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000923110.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.3273T>G",
          "hgvs_p": "p.Asn1091Lys",
          "transcript": "ENST00000923112.1",
          "protein_id": "ENSP00000593171.1",
          "transcript_support_level": null,
          "aa_start": 1091,
          "aa_end": null,
          "aa_length": 2001,
          "cds_start": 3273,
          "cds_end": null,
          "cds_length": 6006,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000923112.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.3267T>G",
          "hgvs_p": "p.Asn1089Lys",
          "transcript": "ENST00000923117.1",
          "protein_id": "ENSP00000593176.1",
          "transcript_support_level": null,
          "aa_start": 1089,
          "aa_end": null,
          "aa_length": 1999,
          "cds_start": 3267,
          "cds_end": null,
          "cds_length": 6000,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000923117.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.3255T>G",
          "hgvs_p": "p.Asn1085Lys",
          "transcript": "ENST00000923113.1",
          "protein_id": "ENSP00000593172.1",
          "transcript_support_level": null,
          "aa_start": 1085,
          "aa_end": null,
          "aa_length": 1995,
          "cds_start": 3255,
          "cds_end": null,
          "cds_length": 5988,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000923113.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.3123T>G",
          "hgvs_p": "p.Asn1041Lys",
          "transcript": "ENST00000960156.1",
          "protein_id": "ENSP00000630215.1",
          "transcript_support_level": null,
          "aa_start": 1041,
          "aa_end": null,
          "aa_length": 1951,
          "cds_start": 3123,
          "cds_end": null,
          "cds_length": 5856,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000960156.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 18,
          "exon_rank_end": null,
          "exon_count": 40,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.3123T>G",
          "hgvs_p": "p.Asn1041Lys",
          "transcript": "ENST00000960157.1",
          "protein_id": "ENSP00000630216.1",
          "transcript_support_level": null,
          "aa_start": 1041,
          "aa_end": null,
          "aa_length": 1951,
          "cds_start": 3123,
          "cds_end": null,
          "cds_length": 5856,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000960157.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 39,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.3105T>G",
          "hgvs_p": "p.Asn1035Lys",
          "transcript": "ENST00000923115.1",
          "protein_id": "ENSP00000593174.1",
          "transcript_support_level": null,
          "aa_start": 1035,
          "aa_end": null,
          "aa_length": 1945,
          "cds_start": 3105,
          "cds_end": null,
          "cds_length": 5838,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000923115.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.3123T>G",
          "hgvs_p": "p.Asn1041Lys",
          "transcript": "ENST00000960158.1",
          "protein_id": "ENSP00000630217.1",
          "transcript_support_level": null,
          "aa_start": 1041,
          "aa_end": null,
          "aa_length": 1896,
          "cds_start": 3123,
          "cds_end": null,
          "cds_length": 5691,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000960158.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 38,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.2955T>G",
          "hgvs_p": "p.Asn985Lys",
          "transcript": "ENST00000923114.1",
          "protein_id": "ENSP00000593173.1",
          "transcript_support_level": null,
          "aa_start": 985,
          "aa_end": null,
          "aa_length": 1895,
          "cds_start": 2955,
          "cds_end": null,
          "cds_length": 5688,
          "cdna_start": null,
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          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000923114.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 19,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.3396T>G",
          "hgvs_p": "p.Asn1132Lys",
          "transcript": "ENST00000452564.1",
          "protein_id": "ENSP00000405736.1",
          "transcript_support_level": 2,
          "aa_start": 1132,
          "aa_end": null,
          "aa_length": 1383,
          "cds_start": 3396,
          "cds_end": null,
          "cds_length": 4152,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000452564.1"
        },
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 43,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.3600T>G",
          "hgvs_p": "p.Asn1200Lys",
          "transcript": "XM_011510778.4",
          "protein_id": "XP_011509080.1",
          "transcript_support_level": null,
          "aa_start": 1200,
          "aa_end": null,
          "aa_length": 2110,
          "cds_start": 3600,
          "cds_end": null,
          "cds_length": 6333,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "XM_011510778.4"
        },
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 43,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.3600T>G",
          "hgvs_p": "p.Asn1200Lys",
          "transcript": "XM_011510779.3",
          "protein_id": "XP_011509081.1",
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          "aa_end": null,
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          "cds_start": 3600,
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          "cds_length": 6333,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "XM_011510779.3"
        },
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 43,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.3597T>G",
          "hgvs_p": "p.Asn1199Lys",
          "transcript": "XM_011510780.3",
          "protein_id": "XP_011509082.1",
          "transcript_support_level": null,
          "aa_start": 1199,
          "aa_end": null,
          "aa_length": 2109,
          "cds_start": 3597,
          "cds_end": null,
          "cds_length": 6330,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011510780.3"
        },
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 21,
          "exon_rank_end": null,
          "exon_count": 43,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.3582T>G",
          "hgvs_p": "p.Asn1194Lys",
          "transcript": "XM_011510781.4",
          "protein_id": "XP_011509083.1",
          "transcript_support_level": null,
          "aa_start": 1194,
          "aa_end": null,
          "aa_length": 2104,
          "cds_start": 3582,
          "cds_end": null,
          "cds_length": 6315,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_011510781.4"
        },
        {
          "aa_ref": "N",
          "aa_alt": "K",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 20,
          "exon_rank_end": null,
          "exon_count": 42,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "PIKFYVE",
          "gene_hgnc_id": 23785,
          "hgvs_c": "c.3564T>G",
          "hgvs_p": "p.Asn1188Lys",
          "transcript": "XM_047443667.1",
          "protein_id": "XP_047299623.1",
          "transcript_support_level": null,
          "aa_start": 1188,
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      "clinvar_disease": "",
      "clinvar_classification": "",
      "clinvar_review_status": "",
      "clinvar_submissions_summary": "",
      "phenotype_combined": null,
      "pathogenicity_classification_combined": null,
      "custom_annotations": null
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  "message": null
}