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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-219421475-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=219421475&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 219421475,
"ref": "G",
"alt": "T",
"effect": "stop_gained",
"transcript": "NM_001927.4",
"consequences": [
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1159G>T",
"hgvs_p": "p.Glu387*",
"transcript": "NM_001927.4",
"protein_id": "NP_001918.3",
"transcript_support_level": null,
"aa_start": 387,
"aa_end": null,
"aa_length": 470,
"cds_start": 1159,
"cds_end": null,
"cds_length": 1413,
"cdna_start": 1245,
"cdna_end": null,
"cdna_length": 2243,
"mane_select": "ENST00000373960.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001927.4"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1159G>T",
"hgvs_p": "p.Glu387*",
"transcript": "ENST00000373960.4",
"protein_id": "ENSP00000363071.3",
"transcript_support_level": 1,
"aa_start": 387,
"aa_end": null,
"aa_length": 470,
"cds_start": 1159,
"cds_end": null,
"cds_length": 1413,
"cdna_start": 1245,
"cdna_end": null,
"cdna_length": 2243,
"mane_select": "NM_001927.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000373960.4"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1159G>T",
"hgvs_p": "p.Glu387*",
"transcript": "ENST00000942906.1",
"protein_id": "ENSP00000612965.1",
"transcript_support_level": null,
"aa_start": 387,
"aa_end": null,
"aa_length": 511,
"cds_start": 1159,
"cds_end": null,
"cds_length": 1536,
"cdna_start": 1194,
"cdna_end": null,
"cdna_length": 2313,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942906.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1159G>T",
"hgvs_p": "p.Glu387*",
"transcript": "ENST00000942898.1",
"protein_id": "ENSP00000612957.1",
"transcript_support_level": null,
"aa_start": 387,
"aa_end": null,
"aa_length": 508,
"cds_start": 1159,
"cds_end": null,
"cds_length": 1527,
"cdna_start": 1245,
"cdna_end": null,
"cdna_length": 2359,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942898.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1159G>T",
"hgvs_p": "p.Glu387*",
"transcript": "ENST00000869000.1",
"protein_id": "ENSP00000539059.1",
"transcript_support_level": null,
"aa_start": 387,
"aa_end": null,
"aa_length": 506,
"cds_start": 1159,
"cds_end": null,
"cds_length": 1521,
"cdna_start": 1245,
"cdna_end": null,
"cdna_length": 2349,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000869000.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1159G>T",
"hgvs_p": "p.Glu387*",
"transcript": "ENST00000868999.1",
"protein_id": "ENSP00000539058.1",
"transcript_support_level": null,
"aa_start": 387,
"aa_end": null,
"aa_length": 494,
"cds_start": 1159,
"cds_end": null,
"cds_length": 1485,
"cdna_start": 1245,
"cdna_end": null,
"cdna_length": 2315,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868999.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1159G>T",
"hgvs_p": "p.Glu387*",
"transcript": "ENST00000942903.1",
"protein_id": "ENSP00000612962.1",
"transcript_support_level": null,
"aa_start": 387,
"aa_end": null,
"aa_length": 490,
"cds_start": 1159,
"cds_end": null,
"cds_length": 1473,
"cdna_start": 1245,
"cdna_end": null,
"cdna_length": 2301,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942903.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1159G>T",
"hgvs_p": "p.Glu387*",
"transcript": "ENST00000868989.1",
"protein_id": "ENSP00000539048.1",
"transcript_support_level": null,
"aa_start": 387,
"aa_end": null,
"aa_length": 486,
"cds_start": 1159,
"cds_end": null,
"cds_length": 1461,
"cdna_start": 2148,
"cdna_end": null,
"cdna_length": 3194,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868989.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1159G>T",
"hgvs_p": "p.Glu387*",
"transcript": "ENST00000868993.1",
"protein_id": "ENSP00000539052.1",
"transcript_support_level": null,
"aa_start": 387,
"aa_end": null,
"aa_length": 478,
"cds_start": 1159,
"cds_end": null,
"cds_length": 1437,
"cdna_start": 1245,
"cdna_end": null,
"cdna_length": 2272,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868993.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1159G>T",
"hgvs_p": "p.Glu387*",
"transcript": "ENST00000868996.1",
"protein_id": "ENSP00000539055.1",
"transcript_support_level": null,
"aa_start": 387,
"aa_end": null,
"aa_length": 477,
"cds_start": 1159,
"cds_end": null,
"cds_length": 1434,
"cdna_start": 1245,
"cdna_end": null,
"cdna_length": 2266,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868996.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1177G>T",
"hgvs_p": "p.Glu393*",
"transcript": "ENST00000868997.1",
"protein_id": "ENSP00000539056.1",
"transcript_support_level": null,
"aa_start": 393,
"aa_end": null,
"aa_length": 476,
"cds_start": 1177,
"cds_end": null,
"cds_length": 1431,
"cdna_start": 1263,
"cdna_end": null,
"cdna_length": 2261,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868997.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1156G>T",
"hgvs_p": "p.Glu386*",
"transcript": "NM_001382708.1",
"protein_id": "NP_001369637.1",
"transcript_support_level": null,
"aa_start": 386,
"aa_end": null,
"aa_length": 469,
"cds_start": 1156,
"cds_end": null,
"cds_length": 1410,
"cdna_start": 1242,
"cdna_end": null,
"cdna_length": 2240,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001382708.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1156G>T",
"hgvs_p": "p.Glu386*",
"transcript": "ENST00000868992.1",
"protein_id": "ENSP00000539051.1",
"transcript_support_level": null,
"aa_start": 386,
"aa_end": null,
"aa_length": 469,
"cds_start": 1156,
"cds_end": null,
"cds_length": 1410,
"cdna_start": 1242,
"cdna_end": null,
"cdna_length": 2245,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868992.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1147G>T",
"hgvs_p": "p.Glu383*",
"transcript": "ENST00000942892.1",
"protein_id": "ENSP00000612951.1",
"transcript_support_level": null,
"aa_start": 383,
"aa_end": null,
"aa_length": 466,
"cds_start": 1147,
"cds_end": null,
"cds_length": 1401,
"cdna_start": 1235,
"cdna_end": null,
"cdna_length": 2237,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942892.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1159G>T",
"hgvs_p": "p.Glu387*",
"transcript": "ENST00000942901.1",
"protein_id": "ENSP00000612960.1",
"transcript_support_level": null,
"aa_start": 387,
"aa_end": null,
"aa_length": 466,
"cds_start": 1159,
"cds_end": null,
"cds_length": 1401,
"cdna_start": 1245,
"cdna_end": null,
"cdna_length": 2231,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942901.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1159G>T",
"hgvs_p": "p.Glu387*",
"transcript": "NM_001382712.1",
"protein_id": "NP_001369641.1",
"transcript_support_level": null,
"aa_start": 387,
"aa_end": null,
"aa_length": 465,
"cds_start": 1159,
"cds_end": null,
"cds_length": 1398,
"cdna_start": 1245,
"cdna_end": null,
"cdna_length": 1639,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001382712.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1141G>T",
"hgvs_p": "p.Glu381*",
"transcript": "ENST00000868990.1",
"protein_id": "ENSP00000539049.1",
"transcript_support_level": null,
"aa_start": 381,
"aa_end": null,
"aa_length": 464,
"cds_start": 1141,
"cds_end": null,
"cds_length": 1395,
"cdna_start": 1227,
"cdna_end": null,
"cdna_length": 2230,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868990.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1141G>T",
"hgvs_p": "p.Glu381*",
"transcript": "ENST00000942893.1",
"protein_id": "ENSP00000612952.1",
"transcript_support_level": null,
"aa_start": 381,
"aa_end": null,
"aa_length": 464,
"cds_start": 1141,
"cds_end": null,
"cds_length": 1395,
"cdna_start": 1227,
"cdna_end": null,
"cdna_length": 2229,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942893.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1138G>T",
"hgvs_p": "p.Glu380*",
"transcript": "NM_001382711.1",
"protein_id": "NP_001369640.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 463,
"cds_start": 1138,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 1224,
"cdna_end": null,
"cdna_length": 2222,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001382711.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1138G>T",
"hgvs_p": "p.Glu380*",
"transcript": "ENST00000868998.1",
"protein_id": "ENSP00000539057.1",
"transcript_support_level": null,
"aa_start": 380,
"aa_end": null,
"aa_length": 463,
"cds_start": 1138,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 1224,
"cdna_end": null,
"cdna_length": 2222,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000868998.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1159G>T",
"hgvs_p": "p.Glu387*",
"transcript": "ENST00000942891.1",
"protein_id": "ENSP00000612950.1",
"transcript_support_level": null,
"aa_start": 387,
"aa_end": null,
"aa_length": 463,
"cds_start": 1159,
"cds_end": null,
"cds_length": 1392,
"cdna_start": 1280,
"cdna_end": null,
"cdna_length": 2260,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942891.1"
},
{
"aa_ref": "E",
"aa_alt": "*",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"stop_gained"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "DES",
"gene_hgnc_id": 2770,
"hgvs_c": "c.1159G>T",
"hgvs_p": "p.Glu387*",
"transcript": "ENST00000942894.1",
"protein_id": "ENSP00000612953.1",
"transcript_support_level": null,
"aa_start": 387,
"aa_end": null,
"aa_length": 462,
"cds_start": 1159,
"cds_end": null,
"cds_length": 1389,
"cdna_start": 1245,
"cdna_end": null,
"cdna_length": 2222,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000942894.1"
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