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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-224990155-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=224990155&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 224990155,
"ref": "G",
"alt": "A",
"effect": "intron_variant",
"transcript": "ENST00000258390.12",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 56,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DOCK10",
"gene_hgnc_id": 23479,
"hgvs_c": "c.123+52097C>T",
"hgvs_p": null,
"transcript": "NM_014689.3",
"protein_id": "NP_055504.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2186,
"cds_start": -4,
"cds_end": null,
"cds_length": 6561,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7286,
"mane_select": "ENST00000258390.12",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 56,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DOCK10",
"gene_hgnc_id": 23479,
"hgvs_c": "c.123+52097C>T",
"hgvs_p": null,
"transcript": "ENST00000258390.12",
"protein_id": "ENSP00000258390.7",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 2186,
"cds_start": -4,
"cds_end": null,
"cds_length": 6561,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7286,
"mane_select": "NM_014689.3",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DOCK10",
"gene_hgnc_id": 23479,
"hgvs_c": "n.191+52097C>T",
"hgvs_p": null,
"transcript": "ENST00000492369.5",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 3837,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DOCK10",
"gene_hgnc_id": 23479,
"hgvs_c": "n.194+52097C>T",
"hgvs_p": null,
"transcript": "ENST00000435582.1",
"protein_id": null,
"transcript_support_level": 3,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 592,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 2,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DOCK10",
"gene_hgnc_id": 23479,
"hgvs_c": "n.134-6346C>T",
"hgvs_p": null,
"transcript": "ENST00000458608.1",
"protein_id": null,
"transcript_support_level": 4,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 528,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 58,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DOCK10",
"gene_hgnc_id": 23479,
"hgvs_c": "n.123+52097C>T",
"hgvs_p": null,
"transcript": "ENST00000698070.1",
"protein_id": "ENSP00000513542.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7267,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 57,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DOCK10",
"gene_hgnc_id": 23479,
"hgvs_c": "c.123+52097C>T",
"hgvs_p": null,
"transcript": "XM_047444918.1",
"protein_id": "XP_047300874.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2193,
"cds_start": -4,
"cds_end": null,
"cds_length": 6582,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7362,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 57,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DOCK10",
"gene_hgnc_id": 23479,
"hgvs_c": "c.123+52097C>T",
"hgvs_p": null,
"transcript": "XM_047444921.1",
"protein_id": "XP_047300877.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2184,
"cds_start": -4,
"cds_end": null,
"cds_length": 6555,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7335,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 56,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DOCK10",
"gene_hgnc_id": 23479,
"hgvs_c": "c.123+52097C>T",
"hgvs_p": null,
"transcript": "XM_047444922.1",
"protein_id": "XP_047300878.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2177,
"cds_start": -4,
"cds_end": null,
"cds_length": 6534,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7259,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 56,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DOCK10",
"gene_hgnc_id": 23479,
"hgvs_c": "c.123+52097C>T",
"hgvs_p": null,
"transcript": "XM_047444929.1",
"protein_id": "XP_047300885.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2144,
"cds_start": -4,
"cds_end": null,
"cds_length": 6435,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7215,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 55,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "DOCK10",
"gene_hgnc_id": 23479,
"hgvs_c": "c.123+52097C>T",
"hgvs_p": null,
"transcript": "XM_047444930.1",
"protein_id": "XP_047300886.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 2137,
"cds_start": -4,
"cds_end": null,
"cds_length": 6414,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 7139,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
}
],
"gene_symbol": "DOCK10",
"gene_hgnc_id": 23479,
"dbsnp": "rs583608",
"frequency_reference_population": 0.5152639,
"hom_count_reference_population": 22721,
"allele_count_reference_population": 78350,
"gnomad_exomes_af": null,
"gnomad_genomes_af": 0.515264,
"gnomad_exomes_ac": null,
"gnomad_genomes_ac": 78350,
"gnomad_exomes_homalt": null,
"gnomad_genomes_homalt": 22721,
"gnomad_mito_homoplasmic": null,
"gnomad_mito_heteroplasmic": null,
"computational_score_selected": -0.5299999713897705,
"computational_prediction_selected": "Benign",
"computational_source_selected": "BayesDel_noAF",
"splice_score_selected": 0,
"splice_prediction_selected": "Benign",
"splice_source_selected": "max_spliceai",
"revel_score": null,
"revel_prediction": null,
"alphamissense_score": null,
"alphamissense_prediction": null,
"bayesdelnoaf_score": -0.53,
"bayesdelnoaf_prediction": "Benign",
"phylop100way_score": 1.125,
"phylop100way_prediction": "Benign",
"spliceai_max_score": 0,
"spliceai_max_prediction": "Benign",
"dbscsnv_ada_score": null,
"dbscsnv_ada_prediction": null,
"apogee2_score": null,
"apogee2_prediction": null,
"mitotip_score": null,
"mitotip_prediction": null,
"acmg_score": -12,
"acmg_classification": "Benign",
"acmg_criteria": "BP4_Strong,BA1",
"acmg_by_gene": [
{
"score": -12,
"benign_score": 12,
"pathogenic_score": 0,
"criteria": [
"BP4_Strong",
"BA1"
],
"verdict": "Benign",
"transcript": "ENST00000258390.12",
"gene_symbol": "DOCK10",
"hgnc_id": 23479,
"effects": [
"intron_variant"
],
"inheritance_mode": "AR",
"hgvs_c": "c.123+52097C>T",
"hgvs_p": null
}
],
"clinvar_disease": "",
"clinvar_classification": "",
"clinvar_review_status": "",
"clinvar_submissions_summary": "",
"phenotype_combined": null,
"pathogenicity_classification_combined": null,
"custom_annotations": null
}
],
"message": null
}