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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-231294499-T-C (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=231294499&ref=T&alt=C&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "2",
      "pos": 231294499,
      "ref": "T",
      "alt": "C",
      "effect": "intron_variant",
      "transcript": "NM_001271466.4",
      "consequences": [
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": 18,
          "intron_rank_end": null,
          "gene_symbol": "ARMC9",
          "gene_hgnc_id": 20730,
          "hgvs_c": "c.1718-1699T>C",
          "hgvs_p": null,
          "transcript": "NM_001352754.2",
          "protein_id": "NP_001339683.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 818,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2457,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 7879,
          "mane_select": "ENST00000611582.5",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001352754.2"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": 18,
          "intron_rank_end": null,
          "gene_symbol": "ARMC9",
          "gene_hgnc_id": 20730,
          "hgvs_c": "c.1718-1699T>C",
          "hgvs_p": null,
          "transcript": "ENST00000611582.5",
          "protein_id": "ENSP00000484804.1",
          "transcript_support_level": 5,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 818,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2457,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 7879,
          "mane_select": "NM_001352754.2",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000611582.5"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 21,
          "intron_rank": 18,
          "intron_rank_end": null,
          "gene_symbol": "ARMC9",
          "gene_hgnc_id": 20730,
          "hgvs_c": "c.1718-1699T>C",
          "hgvs_p": null,
          "transcript": "ENST00000349938.8",
          "protein_id": "ENSP00000258417.5",
          "transcript_support_level": 1,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 665,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 1998,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 2300,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000349938.8"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": 18,
          "intron_rank_end": null,
          "gene_symbol": "ARMC9",
          "gene_hgnc_id": 20730,
          "hgvs_c": "c.1718-1699T>C",
          "hgvs_p": null,
          "transcript": "ENST00000958134.1",
          "protein_id": "ENSP00000628193.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 856,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2571,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 3330,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000958134.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 26,
          "intron_rank": 18,
          "intron_rank_end": null,
          "gene_symbol": "ARMC9",
          "gene_hgnc_id": 20730,
          "hgvs_c": "c.1718-1699T>C",
          "hgvs_p": null,
          "transcript": "ENST00000958131.1",
          "protein_id": "ENSP00000628190.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 855,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2568,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 5682,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000958131.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": 18,
          "intron_rank_end": null,
          "gene_symbol": "ARMC9",
          "gene_hgnc_id": 20730,
          "hgvs_c": "c.1718-1699T>C",
          "hgvs_p": null,
          "transcript": "NM_001271466.4",
          "protein_id": "NP_001258395.2",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 818,
          "cds_start": null,
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          "cds_length": 2457,
          "cdna_start": null,
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          "cdna_length": 8122,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001271466.4"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": 18,
          "intron_rank_end": null,
          "gene_symbol": "ARMC9",
          "gene_hgnc_id": 20730,
          "hgvs_c": "c.1718-1699T>C",
          "hgvs_p": null,
          "transcript": "ENST00000909244.1",
          "protein_id": "ENSP00000579303.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 818,
          "cds_start": null,
          "cds_end": null,
          "cds_length": 2457,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": 5088,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000909244.1"
        },
        {
          "aa_ref": null,
          "aa_alt": null,
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "intron_variant"
          ],
          "exon_rank": null,
          "exon_rank_end": null,
          "exon_count": 25,
          "intron_rank": 18,
          "intron_rank_end": null,
          "gene_symbol": "ARMC9",
          "gene_hgnc_id": 20730,
          "hgvs_c": "c.1718-1699T>C",
          "hgvs_p": null,
          "transcript": "ENST00000909246.1",
          "protein_id": "ENSP00000579305.1",
          "transcript_support_level": null,
          "aa_start": null,
          "aa_end": null,
          "aa_length": 818,
          "cds_start": null,
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          "cds_length": 2457,
          "cdna_start": null,
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          "cdna_length": 3902,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
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        },
        {
          "aa_ref": null,
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          "canonical": false,
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          "consequences": [
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          "intron_rank": 18,
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          "gene_symbol": "ARMC9",
          "gene_hgnc_id": 20730,
          "hgvs_c": "c.1718-1699T>C",
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          "transcript": "ENST00000958133.1",
          "protein_id": "ENSP00000628192.1",
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          "mane_select": null,
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        {
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          "gene_symbol": "ARMC9",
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        {
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          "transcript": "NM_001291656.2",
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.