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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-233760973-C-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=233760973&ref=C&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 233760973,
"ref": "C",
"alt": "A",
"effect": "missense_variant",
"transcript": "NM_000463.3",
"consequences": [
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UGT1A1",
"gene_hgnc_id": 12530,
"hgvs_c": "c.686C>A",
"hgvs_p": "p.Pro229Gln",
"transcript": "NM_000463.3",
"protein_id": "NP_000454.1",
"transcript_support_level": null,
"aa_start": 229,
"aa_end": null,
"aa_length": 533,
"cds_start": 686,
"cds_end": null,
"cds_length": 1602,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000305208.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_000463.3"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UGT1A1",
"gene_hgnc_id": 12530,
"hgvs_c": "c.686C>A",
"hgvs_p": "p.Pro229Gln",
"transcript": "ENST00000305208.10",
"protein_id": "ENSP00000304845.5",
"transcript_support_level": 1,
"aa_start": 229,
"aa_end": null,
"aa_length": 533,
"cds_start": 686,
"cds_end": null,
"cds_length": 1602,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_000463.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000305208.10"
},
{
"aa_ref": "P",
"aa_alt": "Q",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 1,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UGT1A1",
"gene_hgnc_id": 12530,
"hgvs_c": "c.686C>A",
"hgvs_p": "p.Pro229Gln",
"transcript": "ENST00000360418.4",
"protein_id": "ENSP00000353593.3",
"transcript_support_level": 1,
"aa_start": 229,
"aa_end": null,
"aa_length": 444,
"cds_start": 686,
"cds_end": null,
"cds_length": 1335,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000360418.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UGT1A4",
"gene_hgnc_id": 12536,
"hgvs_c": "c.868-6061C>A",
"hgvs_p": null,
"transcript": "NM_007120.3",
"protein_id": "NP_009051.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 534,
"cds_start": null,
"cds_end": null,
"cds_length": 1605,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000373409.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_007120.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UGT1A5",
"gene_hgnc_id": 12537,
"hgvs_c": "c.868-6061C>A",
"hgvs_p": null,
"transcript": "NM_019078.2",
"protein_id": "NP_061951.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 534,
"cds_start": null,
"cds_end": null,
"cds_length": 1605,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000373414.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_019078.2"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UGT1A3",
"gene_hgnc_id": 12535,
"hgvs_c": "c.868-6061C>A",
"hgvs_p": null,
"transcript": "NM_019093.4",
"protein_id": "NP_061966.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 534,
"cds_start": null,
"cds_end": null,
"cds_length": 1605,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000482026.6",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_019093.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UGT1A4",
"gene_hgnc_id": 12536,
"hgvs_c": "c.868-6061C>A",
"hgvs_p": null,
"transcript": "ENST00000373409.8",
"protein_id": "ENSP00000362508.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 534,
"cds_start": null,
"cds_end": null,
"cds_length": 1605,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_007120.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000373409.8"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UGT1A5",
"gene_hgnc_id": 12537,
"hgvs_c": "c.868-6061C>A",
"hgvs_p": null,
"transcript": "ENST00000373414.4",
"protein_id": "ENSP00000362513.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 534,
"cds_start": null,
"cds_end": null,
"cds_length": 1605,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_019078.2",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000373414.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UGT1A3",
"gene_hgnc_id": 12535,
"hgvs_c": "c.868-6061C>A",
"hgvs_p": null,
"transcript": "ENST00000482026.6",
"protein_id": "ENSP00000418532.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 534,
"cds_start": null,
"cds_end": null,
"cds_length": 1605,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_019093.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000482026.6"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UGT1A6",
"gene_hgnc_id": 12538,
"hgvs_c": "c.862-6061C>A",
"hgvs_p": null,
"transcript": "NM_001072.4",
"protein_id": "NP_001063.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 532,
"cds_start": null,
"cds_end": null,
"cds_length": 1599,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000305139.11",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001072.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UGT1A6",
"gene_hgnc_id": 12538,
"hgvs_c": "c.862-6061C>A",
"hgvs_p": null,
"transcript": "ENST00000305139.11",
"protein_id": "ENSP00000303174.6",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 532,
"cds_start": null,
"cds_end": null,
"cds_length": 1599,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_001072.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000305139.11"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UGT1A10",
"gene_hgnc_id": 12531,
"hgvs_c": "c.856-6061C>A",
"hgvs_p": null,
"transcript": "NM_019075.4",
"protein_id": "NP_061948.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 530,
"cds_start": null,
"cds_end": null,
"cds_length": 1593,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000344644.10",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_019075.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UGT1A8",
"gene_hgnc_id": 12540,
"hgvs_c": "c.856-6061C>A",
"hgvs_p": null,
"transcript": "NM_019076.5",
"protein_id": "NP_061949.3",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 530,
"cds_start": null,
"cds_end": null,
"cds_length": 1593,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000373450.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_019076.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UGT1A7",
"gene_hgnc_id": 12539,
"hgvs_c": "c.856-6061C>A",
"hgvs_p": null,
"transcript": "NM_019077.3",
"protein_id": "NP_061950.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 530,
"cds_start": null,
"cds_end": null,
"cds_length": 1593,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000373426.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_019077.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UGT1A9",
"gene_hgnc_id": 12541,
"hgvs_c": "c.856-6061C>A",
"hgvs_p": null,
"transcript": "NM_021027.3",
"protein_id": "NP_066307.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 530,
"cds_start": null,
"cds_end": null,
"cds_length": 1593,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000354728.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_021027.3"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UGT1A10",
"gene_hgnc_id": 12531,
"hgvs_c": "c.856-6061C>A",
"hgvs_p": null,
"transcript": "ENST00000344644.10",
"protein_id": "ENSP00000343838.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 530,
"cds_start": null,
"cds_end": null,
"cds_length": 1593,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_019075.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000344644.10"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UGT1A9",
"gene_hgnc_id": 12541,
"hgvs_c": "c.856-6061C>A",
"hgvs_p": null,
"transcript": "ENST00000354728.5",
"protein_id": "ENSP00000346768.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 530,
"cds_start": null,
"cds_end": null,
"cds_length": 1593,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_021027.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000354728.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UGT1A7",
"gene_hgnc_id": 12539,
"hgvs_c": "c.856-6061C>A",
"hgvs_p": null,
"transcript": "ENST00000373426.4",
"protein_id": "ENSP00000362525.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 530,
"cds_start": null,
"cds_end": null,
"cds_length": 1593,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_019077.3",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000373426.4"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UGT1A8",
"gene_hgnc_id": 12540,
"hgvs_c": "c.856-6061C>A",
"hgvs_p": null,
"transcript": "ENST00000373450.5",
"protein_id": "ENSP00000362549.4",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 530,
"cds_start": null,
"cds_end": null,
"cds_length": 1593,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_019076.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000373450.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UGT1A10",
"gene_hgnc_id": 12531,
"hgvs_c": "c.856-6061C>A",
"hgvs_p": null,
"transcript": "ENST00000373445.1",
"protein_id": "ENSP00000362544.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 441,
"cds_start": null,
"cds_end": null,
"cds_length": 1326,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000373445.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 5,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UGT1A6",
"gene_hgnc_id": 12538,
"hgvs_c": "c.61-6061C>A",
"hgvs_p": null,
"transcript": "ENST00000406651.1",
"protein_id": "ENSP00000386107.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 176,
"cds_start": null,
"cds_end": null,
"cds_length": 531,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000406651.1"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 6,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "UGT1A4",
"gene_hgnc_id": 12536,
"hgvs_c": "n.868-6061C>A",
"hgvs_p": null,
"transcript": "ENST00000450233.1",
"protein_id": "ENSP00000408608.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
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"bayesdelnoaf_score": -0.16,
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"phylop100way_score": 0.857,
"phylop100way_prediction": "Benign",
"spliceai_max_score": 0.02,
"spliceai_max_prediction": "Benign",
"dbscsnv_ada_score": null,
"dbscsnv_ada_prediction": null,
"apogee2_score": null,
"apogee2_prediction": null,
"mitotip_score": null,
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"acmg_score": -6,
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"acmg_criteria": "PM5,PP2,BP4_Strong,BS1_Supporting,BS2",
"acmg_by_gene": [
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"BP4_Strong",
"BS1_Supporting",
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"verdict": "Likely_benign",
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{
"score": -9,
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{
"score": -9,
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"BS2"
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"verdict": "Benign",
"transcript": "NM_019078.2",
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{
"score": -9,
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"BS2"
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"verdict": "Benign",
"transcript": "NM_019093.4",
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{
"score": -9,
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"BS2"
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"verdict": "Benign",
"transcript": "NM_001072.4",
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"effects": [
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"inheritance_mode": "",
"hgvs_c": "c.862-6061C>A",
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},
{
"score": -9,
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"criteria": [
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"BS1_Supporting",
"BS2"
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"verdict": "Benign",
"transcript": "NM_019075.4",
"gene_symbol": "UGT1A10",
"hgnc_id": 12531,
"effects": [
"intron_variant"
],
"inheritance_mode": "",
"hgvs_c": "c.856-6061C>A",
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},
{
"score": -9,
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"criteria": [
"BP4_Strong",
"BS1_Supporting",
"BS2"
],
"verdict": "Benign",
"transcript": "NM_019076.5",
"gene_symbol": "UGT1A8",
"hgnc_id": 12540,
"effects": [
"intron_variant"
],
"inheritance_mode": "",
"hgvs_c": "c.856-6061C>A",
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},
{
"score": -9,
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"criteria": [
"BP4_Strong",
"BS1_Supporting",
"BS2"
],
"verdict": "Benign",
"transcript": "NM_019077.3",
"gene_symbol": "UGT1A7",
"hgnc_id": 12539,
"effects": [
"intron_variant"
],
"inheritance_mode": "",
"hgvs_c": "c.856-6061C>A",
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},
{
"score": -9,
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"criteria": [
"BP4_Strong",
"BS1_Supporting",
"BS2"
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"verdict": "Benign",
"transcript": "NM_021027.3",
"gene_symbol": "UGT1A9",
"hgnc_id": 12541,
"effects": [
"intron_variant"
],
"inheritance_mode": "",
"hgvs_c": "c.856-6061C>A",
"hgvs_p": null
},
{
"score": -9,
"benign_score": 9,
"pathogenic_score": 0,
"criteria": [
"BP4_Strong",
"BS1_Supporting",
"BS2"
],
"verdict": "Benign",
"transcript": "",
"gene_symbol": "UGT1A",
"hgnc_id": 12529,
"effects": [
"intragenic_variant"
],
"inheritance_mode": "",
"hgvs_c": "n.233760973C>A",
"hgvs_p": null
}
],
"clinvar_disease": " QUANTITATIVE TRAIT LOCUS 1, SERUM LEVEL OF, type II,BILIRUBIN,Crigler-Najjar syndrome,Crigler-Najjar syndrome type 1,Gilbert syndrome,Lucey-Driscoll syndrome,UGT1A1-related disorder,not provided,not specified",
"clinvar_classification": " other,Conflicting classifications of pathogenicity",
"clinvar_review_status": "criteria provided, conflicting classifications",
"clinvar_submissions_summary": "P:3 US:4 B:1 O:1",
"phenotype_combined": "Gilbert syndrome|Crigler-Najjar syndrome, type II|not specified|not provided|UGT1A1-related disorder|Crigler-Najjar syndrome, type II;Lucey-Driscoll syndrome;Crigler-Najjar syndrome type 1;Gilbert syndrome;BILIRUBIN, SERUM LEVEL OF, QUANTITATIVE TRAIT LOCUS 1|Crigler-Najjar syndrome, type II;Lucey-Driscoll syndrome;Crigler-Najjar syndrome type 1;Gilbert syndrome",
"pathogenicity_classification_combined": "Conflicting classifications of pathogenicity; other",
"custom_annotations": null
}
],
"message": null
}