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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-237764060-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=237764060&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 237764060,
"ref": "C",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000308482.14",
"consequences": [
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2347C>T",
"hgvs_p": "p.His783Tyr",
"transcript": "ENST00000392000.4",
"protein_id": "ENSP00000375857.4",
"transcript_support_level": 1,
"aa_start": 783,
"aa_end": null,
"aa_length": 808,
"cds_start": 2347,
"cds_end": null,
"cds_length": 2427,
"cdna_start": 2464,
"cdna_end": null,
"cdna_length": 3365,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2275C>T",
"hgvs_p": "p.His759Tyr",
"transcript": "ENST00000244815.9",
"protein_id": "ENSP00000244815.5",
"transcript_support_level": 1,
"aa_start": 759,
"aa_end": null,
"aa_length": 784,
"cds_start": 2275,
"cds_end": null,
"cds_length": 2355,
"cdna_start": 2515,
"cdna_end": null,
"cdna_length": 4370,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2179C>T",
"hgvs_p": "p.His727Tyr",
"transcript": "ENST00000289175.10",
"protein_id": "ENSP00000289175.6",
"transcript_support_level": 1,
"aa_start": 727,
"aa_end": null,
"aa_length": 752,
"cds_start": 2179,
"cds_end": null,
"cds_length": 2259,
"cdna_start": 2490,
"cdna_end": null,
"cdna_length": 3709,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.1459+3855C>T",
"hgvs_p": null,
"transcript": "NM_001137550.2",
"protein_id": "NP_001131022.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 640,
"cds_start": -4,
"cds_end": null,
"cds_length": 1923,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4092,
"mane_select": "ENST00000308482.14",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": 19,
"intron_rank_end": null,
"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.1459+3855C>T",
"hgvs_p": null,
"transcript": "ENST00000308482.14",
"protein_id": "ENSP00000310109.9",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 640,
"cds_start": -4,
"cds_end": null,
"cds_length": 1923,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4092,
"mane_select": "NM_001137550.2",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2347C>T",
"hgvs_p": "p.His783Tyr",
"transcript": "NM_001137552.2",
"protein_id": "NP_001131024.1",
"transcript_support_level": null,
"aa_start": 783,
"aa_end": null,
"aa_length": 808,
"cds_start": 2347,
"cds_end": null,
"cds_length": 2427,
"cdna_start": 2598,
"cdna_end": null,
"cdna_length": 4453,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 10,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2275C>T",
"hgvs_p": "p.His759Tyr",
"transcript": "NM_004735.4",
"protein_id": "NP_004726.2",
"transcript_support_level": null,
"aa_start": 759,
"aa_end": null,
"aa_length": 784,
"cds_start": 2275,
"cds_end": null,
"cds_length": 2355,
"cdna_start": 2526,
"cdna_end": null,
"cdna_length": 4381,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 8,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2179C>T",
"hgvs_p": "p.His727Tyr",
"transcript": "NM_001137553.2",
"protein_id": "NP_001131025.1",
"transcript_support_level": null,
"aa_start": 727,
"aa_end": null,
"aa_length": 752,
"cds_start": 2179,
"cds_end": null,
"cds_length": 2259,
"cdna_start": 2430,
"cdna_end": null,
"cdna_length": 4285,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 20,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2917C>T",
"hgvs_p": "p.His973Tyr",
"transcript": "XM_047446293.1",
"protein_id": "XP_047302249.1",
"transcript_support_level": null,
"aa_start": 973,
"aa_end": null,
"aa_length": 998,
"cds_start": 2917,
"cds_end": null,
"cds_length": 2997,
"cdna_start": 2975,
"cdna_end": null,
"cdna_length": 4830,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2878C>T",
"hgvs_p": "p.His960Tyr",
"transcript": "XM_047446294.1",
"protein_id": "XP_047302250.1",
"transcript_support_level": null,
"aa_start": 960,
"aa_end": null,
"aa_length": 985,
"cds_start": 2878,
"cds_end": null,
"cds_length": 2958,
"cdna_start": 2936,
"cdna_end": null,
"cdna_length": 4791,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 17,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2728C>T",
"hgvs_p": "p.His910Tyr",
"transcript": "XM_047446295.1",
"protein_id": "XP_047302251.1",
"transcript_support_level": null,
"aa_start": 910,
"aa_end": null,
"aa_length": 935,
"cds_start": 2728,
"cds_end": null,
"cds_length": 2808,
"cdna_start": 2786,
"cdna_end": null,
"cdna_length": 4641,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2689C>T",
"hgvs_p": "p.His897Tyr",
"transcript": "XM_047446296.1",
"protein_id": "XP_047302252.1",
"transcript_support_level": null,
"aa_start": 897,
"aa_end": null,
"aa_length": 922,
"cds_start": 2689,
"cds_end": null,
"cds_length": 2769,
"cdna_start": 2747,
"cdna_end": null,
"cdna_length": 4602,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 16,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2656C>T",
"hgvs_p": "p.His886Tyr",
"transcript": "XM_047446297.1",
"protein_id": "XP_047302253.1",
"transcript_support_level": null,
"aa_start": 886,
"aa_end": null,
"aa_length": 911,
"cds_start": 2656,
"cds_end": null,
"cds_length": 2736,
"cdna_start": 2714,
"cdna_end": null,
"cdna_length": 4569,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
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"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2629C>T",
"hgvs_p": "p.His877Tyr",
"transcript": "XM_047446298.1",
"protein_id": "XP_047302254.1",
"transcript_support_level": null,
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"cds_start": 2629,
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"cdna_start": 2687,
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},
{
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"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2617C>T",
"hgvs_p": "p.His873Tyr",
"transcript": "XM_047446299.1",
"protein_id": "XP_047302255.1",
"transcript_support_level": null,
"aa_start": 873,
"aa_end": null,
"aa_length": 898,
"cds_start": 2617,
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"cdna_start": 2675,
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"cdna_length": 4530,
"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
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"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2593C>T",
"hgvs_p": "p.His865Tyr",
"transcript": "XM_047446300.1",
"protein_id": "XP_047302256.1",
"transcript_support_level": null,
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"mane_select": null,
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"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
"exon_rank_end": null,
"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2563C>T",
"hgvs_p": "p.His855Tyr",
"transcript": "XM_047446301.1",
"protein_id": "XP_047302257.1",
"transcript_support_level": null,
"aa_start": 855,
"aa_end": null,
"aa_length": 880,
"cds_start": 2563,
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"cdna_start": 2621,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
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"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2557C>T",
"hgvs_p": "p.His853Tyr",
"transcript": "XM_047446302.1",
"protein_id": "XP_047302258.1",
"transcript_support_level": null,
"aa_start": 853,
"aa_end": null,
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"cds_start": 2557,
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"cdna_start": 2615,
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 15,
"exon_rank_end": null,
"exon_count": 15,
"intron_rank": null,
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"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2542C>T",
"hgvs_p": "p.His848Tyr",
"transcript": "XM_047446303.1",
"protein_id": "XP_047302259.1",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 13,
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"exon_count": 13,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2533C>T",
"hgvs_p": "p.His845Tyr",
"transcript": "XM_047446304.1",
"protein_id": "XP_047302260.1",
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},
{
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"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
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"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2527C>T",
"hgvs_p": "p.His843Tyr",
"transcript": "XM_047446305.1",
"protein_id": "XP_047302261.1",
"transcript_support_level": null,
"aa_start": 843,
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"mane_select": null,
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"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 14,
"exon_rank_end": null,
"exon_count": 14,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "LRRFIP1",
"gene_hgnc_id": 6702,
"hgvs_c": "c.2470C>T",
"hgvs_p": "p.His824Tyr",
"transcript": "XM_047446306.1",
"protein_id": "XP_047302262.1",
"transcript_support_level": null,
"aa_start": 824,
"aa_end": null,
"aa_length": 849,
"cds_start": 2470,
"cds_end": null,
"cds_length": 2550,
"cdna_start": 2528,
"cdna_end": null,
"cdna_length": 4383,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "H",
"aa_alt": "Y",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 11,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
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