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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-23971290-G-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=23971290&ref=G&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 23971290,
"ref": "G",
"alt": "T",
"effect": "missense_variant",
"transcript": "NM_181713.4",
"consequences": [
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "NM_181713.4",
"protein_id": "NP_859064.2",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000309033.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_181713.4"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000309033.5",
"protein_id": "ENSP00000312107.4",
"transcript_support_level": 1,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_181713.4",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000309033.5"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "n.518G>T",
"hgvs_p": null,
"transcript": "ENST00000446425.2",
"protein_id": null,
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": null,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "pseudogene",
"feature": "ENST00000446425.2"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000404924.5",
"protein_id": "ENSP00000385525.1",
"transcript_support_level": 2,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000404924.5"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000906993.1",
"protein_id": "ENSP00000577052.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906993.1"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000906994.1",
"protein_id": "ENSP00000577053.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906994.1"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000906995.1",
"protein_id": "ENSP00000577054.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906995.1"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000906996.1",
"protein_id": "ENSP00000577055.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906996.1"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000906997.1",
"protein_id": "ENSP00000577056.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906997.1"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000906999.1",
"protein_id": "ENSP00000577058.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000906999.1"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000907000.1",
"protein_id": "ENSP00000577059.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000907000.1"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000907001.1",
"protein_id": "ENSP00000577060.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000907001.1"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000907002.1",
"protein_id": "ENSP00000577061.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000907002.1"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000907003.1",
"protein_id": "ENSP00000577062.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000907003.1"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000912493.1",
"protein_id": "ENSP00000582552.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912493.1"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000912494.1",
"protein_id": "ENSP00000582553.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912494.1"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000912495.1",
"protein_id": "ENSP00000582554.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912495.1"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000912496.1",
"protein_id": "ENSP00000582555.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912496.1"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000912497.1",
"protein_id": "ENSP00000582556.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912497.1"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000951750.1",
"protein_id": "ENSP00000621809.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951750.1"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000951751.1",
"protein_id": "ENSP00000621810.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951751.1"
},
{
"aa_ref": "G",
"aa_alt": "V",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "UBXN2A",
"gene_hgnc_id": 27265,
"hgvs_c": "c.56G>T",
"hgvs_p": "p.Gly19Val",
"transcript": "ENST00000951752.1",
"protein_id": "ENSP00000621811.1",
"transcript_support_level": null,
"aa_start": 19,
"aa_end": null,
"aa_length": 259,
"cds_start": 56,
"cds_end": null,
"cds_length": 780,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000951752.1"
},
{
"aa_ref": "G",
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