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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-241741067-G-A (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=241741067&ref=G&alt=A&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 241741067,
"ref": "G",
"alt": "A",
"effect": "synonymous_variant",
"transcript": "ENST00000321264.9",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "NM_152783.5",
"protein_id": "NP_689996.4",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 521,
"cds_start": 327,
"cds_end": null,
"cds_length": 1566,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 2566,
"mane_select": "ENST00000321264.9",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "ENST00000321264.9",
"protein_id": "ENSP00000315351.4",
"transcript_support_level": 1,
"aa_start": 109,
"aa_end": null,
"aa_length": 521,
"cds_start": 327,
"cds_end": null,
"cds_length": 1566,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 2566,
"mane_select": "NM_152783.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": true,
"consequences": [
"non_coding_transcript_exon_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 12,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "n.327G>A",
"hgvs_p": null,
"transcript": "ENST00000436747.5",
"protein_id": "ENSP00000400212.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4549,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_011511738.4",
"protein_id": "XP_011510040.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 460,
"cds_start": 327,
"cds_end": null,
"cds_length": 1383,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 1685,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_011511739.3",
"protein_id": "XP_011510041.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 460,
"cds_start": 327,
"cds_end": null,
"cds_length": 1383,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 1619,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_011511740.4",
"protein_id": "XP_011510042.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 460,
"cds_start": 327,
"cds_end": null,
"cds_length": 1383,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 1790,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_047445687.1",
"protein_id": "XP_047301643.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 460,
"cds_start": 327,
"cds_end": null,
"cds_length": 1383,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 1877,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_047445692.1",
"protein_id": "XP_047301648.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 454,
"cds_start": 327,
"cds_end": null,
"cds_length": 1365,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 1689,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_017004827.3",
"protein_id": "XP_016860316.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 449,
"cds_start": 327,
"cds_end": null,
"cds_length": 1350,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 1518,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_047445693.1",
"protein_id": "XP_047301649.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 447,
"cds_start": 327,
"cds_end": null,
"cds_length": 1344,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 1599,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_011511741.4",
"protein_id": "XP_011510043.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 441,
"cds_start": 327,
"cds_end": null,
"cds_length": 1326,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 1587,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_011511743.3",
"protein_id": "XP_011510045.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 438,
"cds_start": 327,
"cds_end": null,
"cds_length": 1317,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 1601,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_017004829.3",
"protein_id": "XP_016860318.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 438,
"cds_start": 327,
"cds_end": null,
"cds_length": 1317,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 1536,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_047445694.1",
"protein_id": "XP_047301650.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 438,
"cds_start": 327,
"cds_end": null,
"cds_length": 1317,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 1598,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_047445696.1",
"protein_id": "XP_047301652.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 438,
"cds_start": 327,
"cds_end": null,
"cds_length": 1317,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 1554,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_047445708.1",
"protein_id": "XP_047301664.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 427,
"cds_start": 327,
"cds_end": null,
"cds_length": 1284,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 1480,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 7,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_011511746.4",
"protein_id": "XP_011510048.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 423,
"cds_start": 327,
"cds_end": null,
"cds_length": 1272,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 2724,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 8,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_011511747.4",
"protein_id": "XP_011510049.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 419,
"cds_start": 327,
"cds_end": null,
"cds_length": 1260,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 1521,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_017004830.3",
"protein_id": "XP_016860319.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 418,
"cds_start": 327,
"cds_end": null,
"cds_length": 1257,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 1487,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_047445710.1",
"protein_id": "XP_047301666.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 416,
"cds_start": 327,
"cds_end": null,
"cds_length": 1251,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 1417,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 11,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_047445712.1",
"protein_id": "XP_047301668.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 416,
"cds_start": 327,
"cds_end": null,
"cds_length": 1251,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 1470,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 10,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_011511750.4",
"protein_id": "XP_011510052.1",
"transcript_support_level": null,
"aa_start": 109,
"aa_end": null,
"aa_length": 414,
"cds_start": 327,
"cds_end": null,
"cds_length": 1245,
"cdna_start": 485,
"cdna_end": null,
"cdna_length": 2478,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"synonymous_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 9,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "D2HGDH",
"gene_hgnc_id": 28358,
"hgvs_c": "c.327G>A",
"hgvs_p": "p.Ser109Ser",
"transcript": "XM_047445717.1",
"protein_id": "XP_047301673.1",
"transcript_support_level": null,
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}