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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-24658753-A-C (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=24658753&ref=A&alt=C&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 24658753,
"ref": "A",
"alt": "C",
"effect": "missense_variant",
"transcript": "NM_003743.5",
"consequences": [
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "NM_003743.5",
"protein_id": "NP_003734.3",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 1441,
"cds_start": 76,
"cds_end": null,
"cds_length": 4326,
"cdna_start": 820,
"cdna_end": null,
"cdna_length": 7381,
"mane_select": "ENST00000348332.8",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_003743.5"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": true,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "ENST00000348332.8",
"protein_id": "ENSP00000320940.5",
"transcript_support_level": 1,
"aa_start": 26,
"aa_end": null,
"aa_length": 1441,
"cds_start": 76,
"cds_end": null,
"cds_length": 4326,
"cdna_start": 820,
"cdna_end": null,
"cdna_length": 7381,
"mane_select": "NM_003743.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000348332.8"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "ENST00000395856.3",
"protein_id": "ENSP00000379197.3",
"transcript_support_level": 1,
"aa_start": 26,
"aa_end": null,
"aa_length": 1440,
"cds_start": 76,
"cds_end": null,
"cds_length": 4323,
"cdna_start": 270,
"cdna_end": null,
"cdna_length": 6828,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000395856.3"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "ENST00000288599.9",
"protein_id": "ENSP00000288599.5",
"transcript_support_level": 1,
"aa_start": 26,
"aa_end": null,
"aa_length": 1399,
"cds_start": 76,
"cds_end": null,
"cds_length": 4200,
"cdna_start": 334,
"cdna_end": null,
"cdna_length": 6952,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000288599.9"
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"5_prime_UTR_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.-211A>C",
"hgvs_p": null,
"transcript": "ENST00000407230.5",
"protein_id": "ENSP00000385195.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1248,
"cds_start": null,
"cds_end": null,
"cds_length": 3747,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4745,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000407230.5"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "ENST00000406961.5",
"protein_id": "ENSP00000385216.1",
"transcript_support_level": 5,
"aa_start": 26,
"aa_end": null,
"aa_length": 1441,
"cds_start": 76,
"cds_end": null,
"cds_length": 4326,
"cdna_start": 728,
"cdna_end": null,
"cdna_length": 7289,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000406961.5"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 2,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "ENST00000856014.1",
"protein_id": "ENSP00000526073.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 1441,
"cds_start": 76,
"cds_end": null,
"cds_length": 4326,
"cdna_start": 946,
"cdna_end": null,
"cdna_length": 5343,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000856014.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "ENST00000918340.1",
"protein_id": "ENSP00000588399.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 1441,
"cds_start": 76,
"cds_end": null,
"cds_length": 4326,
"cdna_start": 775,
"cdna_end": null,
"cdna_length": 7336,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000918340.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "ENST00000918341.1",
"protein_id": "ENSP00000588400.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 1441,
"cds_start": 76,
"cds_end": null,
"cds_length": 4326,
"cdna_start": 604,
"cdna_end": null,
"cdna_length": 6972,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000918341.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "ENST00000918342.1",
"protein_id": "ENSP00000588401.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 1441,
"cds_start": 76,
"cds_end": null,
"cds_length": 4326,
"cdna_start": 1164,
"cdna_end": null,
"cdna_length": 6412,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000918342.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "ENST00000918343.1",
"protein_id": "ENSP00000588402.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 1441,
"cds_start": 76,
"cds_end": null,
"cds_length": 4326,
"cdna_start": 1047,
"cdna_end": null,
"cdna_length": 5447,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000918343.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "ENST00000950148.1",
"protein_id": "ENSP00000620207.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 1441,
"cds_start": 76,
"cds_end": null,
"cds_length": 4326,
"cdna_start": 1192,
"cdna_end": null,
"cdna_length": 6437,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950148.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "ENST00000950150.1",
"protein_id": "ENSP00000620209.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 1441,
"cds_start": 76,
"cds_end": null,
"cds_length": 4326,
"cdna_start": 738,
"cdna_end": null,
"cdna_length": 5138,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950150.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "ENST00000950152.1",
"protein_id": "ENSP00000620211.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 1441,
"cds_start": 76,
"cds_end": null,
"cds_length": 4326,
"cdna_start": 912,
"cdna_end": null,
"cdna_length": 5287,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950152.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "ENST00000950153.1",
"protein_id": "ENSP00000620212.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 1441,
"cds_start": 76,
"cds_end": null,
"cds_length": 4326,
"cdna_start": 825,
"cdna_end": null,
"cdna_length": 5198,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950153.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 5,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "ENST00000950156.1",
"protein_id": "ENSP00000620215.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 1441,
"cds_start": 76,
"cds_end": null,
"cds_length": 4326,
"cdna_start": 477,
"cdna_end": null,
"cdna_length": 4877,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950156.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 7,
"exon_rank_end": null,
"exon_count": 25,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "ENST00000950157.1",
"protein_id": "ENSP00000620216.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 1441,
"cds_start": 76,
"cds_end": null,
"cds_length": 4326,
"cdna_start": 1340,
"cdna_end": null,
"cdna_length": 5715,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950157.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "ENST00000950158.1",
"protein_id": "ENSP00000620217.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 1441,
"cds_start": 76,
"cds_end": null,
"cds_length": 4326,
"cdna_start": 620,
"cdna_end": null,
"cdna_length": 4992,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950158.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 6,
"exon_rank_end": null,
"exon_count": 24,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "ENST00000950159.1",
"protein_id": "ENSP00000620218.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 1441,
"cds_start": 76,
"cds_end": null,
"cds_length": 4326,
"cdna_start": 724,
"cdna_end": null,
"cdna_length": 5099,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950159.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "NM_147233.2",
"protein_id": "NP_671766.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 1440,
"cds_start": 76,
"cds_end": null,
"cds_length": 4323,
"cdna_start": 334,
"cdna_end": null,
"cdna_length": 6892,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_147233.2"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 3,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "ENST00000950154.1",
"protein_id": "ENSP00000620213.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 1440,
"cds_start": 76,
"cds_end": null,
"cds_length": 4323,
"cdna_start": 584,
"cdna_end": null,
"cdna_length": 4953,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000950154.1"
},
{
"aa_ref": "T",
"aa_alt": "P",
"canonical": false,
"protein_coding": true,
"strand": true,
"consequences": [
"missense_variant"
],
"exon_rank": 4,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "NCOA1",
"gene_hgnc_id": 7668,
"hgvs_c": "c.76A>C",
"hgvs_p": "p.Thr26Pro",
"transcript": "ENST00000950155.1",
"protein_id": "ENSP00000620214.1",
"transcript_support_level": null,
"aa_start": 26,
"aa_end": null,
"aa_length": 1440,
"cds_start": 76,
"cds_end": null,
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