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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-24823221-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=24823221&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 24823221,
"ref": "T",
"alt": "G",
"effect": "synonymous_variant",
"transcript": "NM_001377128.1",
"consequences": [
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2871A>C",
"hgvs_p": "p.Ser957Ser",
"transcript": "NM_004036.5",
"protein_id": "NP_004027.2",
"transcript_support_level": null,
"aa_start": 957,
"aa_end": null,
"aa_length": 1144,
"cds_start": 2871,
"cds_end": null,
"cds_length": 3435,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "ENST00000679454.1",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_004036.5"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2871A>C",
"hgvs_p": "p.Ser957Ser",
"transcript": "ENST00000679454.1",
"protein_id": "ENSP00000505261.1",
"transcript_support_level": null,
"aa_start": 957,
"aa_end": null,
"aa_length": 1144,
"cds_start": 2871,
"cds_end": null,
"cds_length": 3435,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": "NM_004036.5",
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000679454.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2874A>C",
"hgvs_p": "p.Ser958Ser",
"transcript": "ENST00000405392.6",
"protein_id": "ENSP00000384484.2",
"transcript_support_level": 1,
"aa_start": 958,
"aa_end": null,
"aa_length": 1145,
"cds_start": 2874,
"cds_end": null,
"cds_length": 3438,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000405392.6"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2871A>C",
"hgvs_p": "p.Ser957Ser",
"transcript": "ENST00000260600.9",
"protein_id": "ENSP00000260600.5",
"transcript_support_level": 1,
"aa_start": 957,
"aa_end": null,
"aa_length": 1144,
"cds_start": 2871,
"cds_end": null,
"cds_length": 3435,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000260600.9"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2952A>C",
"hgvs_p": "p.Ser984Ser",
"transcript": "ENST00000912214.1",
"protein_id": "ENSP00000582273.1",
"transcript_support_level": null,
"aa_start": 984,
"aa_end": null,
"aa_length": 1171,
"cds_start": 2952,
"cds_end": null,
"cds_length": 3516,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912214.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2937A>C",
"hgvs_p": "p.Ser979Ser",
"transcript": "NM_001377128.1",
"protein_id": "NP_001364057.1",
"transcript_support_level": null,
"aa_start": 979,
"aa_end": null,
"aa_length": 1166,
"cds_start": 2937,
"cds_end": null,
"cds_length": 3501,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377128.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 19,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2937A>C",
"hgvs_p": "p.Ser979Ser",
"transcript": "ENST00000867857.1",
"protein_id": "ENSP00000537916.1",
"transcript_support_level": null,
"aa_start": 979,
"aa_end": null,
"aa_length": 1166,
"cds_start": 2937,
"cds_end": null,
"cds_length": 3501,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867857.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2931A>C",
"hgvs_p": "p.Ser977Ser",
"transcript": "ENST00000948883.1",
"protein_id": "ENSP00000618942.1",
"transcript_support_level": null,
"aa_start": 977,
"aa_end": null,
"aa_length": 1164,
"cds_start": 2931,
"cds_end": null,
"cds_length": 3495,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948883.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2928A>C",
"hgvs_p": "p.Ser976Ser",
"transcript": "ENST00000912212.1",
"protein_id": "ENSP00000582271.1",
"transcript_support_level": null,
"aa_start": 976,
"aa_end": null,
"aa_length": 1163,
"cds_start": 2928,
"cds_end": null,
"cds_length": 3492,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912212.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2889A>C",
"hgvs_p": "p.Ser963Ser",
"transcript": "ENST00000948874.1",
"protein_id": "ENSP00000618933.1",
"transcript_support_level": null,
"aa_start": 963,
"aa_end": null,
"aa_length": 1150,
"cds_start": 2889,
"cds_end": null,
"cds_length": 3453,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948874.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2886A>C",
"hgvs_p": "p.Ser962Ser",
"transcript": "ENST00000948876.1",
"protein_id": "ENSP00000618935.1",
"transcript_support_level": null,
"aa_start": 962,
"aa_end": null,
"aa_length": 1149,
"cds_start": 2886,
"cds_end": null,
"cds_length": 3450,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948876.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2874A>C",
"hgvs_p": "p.Ser958Ser",
"transcript": "NM_001320613.2",
"protein_id": "NP_001307542.1",
"transcript_support_level": null,
"aa_start": 958,
"aa_end": null,
"aa_length": 1145,
"cds_start": 2874,
"cds_end": null,
"cds_length": 3438,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001320613.2"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2871A>C",
"hgvs_p": "p.Ser957Ser",
"transcript": "NM_001377132.1",
"protein_id": "NP_001364061.1",
"transcript_support_level": null,
"aa_start": 957,
"aa_end": null,
"aa_length": 1144,
"cds_start": 2871,
"cds_end": null,
"cds_length": 3435,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "NM_001377132.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2871A>C",
"hgvs_p": "p.Ser957Ser",
"transcript": "ENST00000948882.1",
"protein_id": "ENSP00000618941.1",
"transcript_support_level": null,
"aa_start": 957,
"aa_end": null,
"aa_length": 1144,
"cds_start": 2871,
"cds_end": null,
"cds_length": 3435,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948882.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2868A>C",
"hgvs_p": "p.Ser956Ser",
"transcript": "ENST00000912211.1",
"protein_id": "ENSP00000582270.1",
"transcript_support_level": null,
"aa_start": 956,
"aa_end": null,
"aa_length": 1143,
"cds_start": 2868,
"cds_end": null,
"cds_length": 3432,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912211.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2868A>C",
"hgvs_p": "p.Ser956Ser",
"transcript": "ENST00000948879.1",
"protein_id": "ENSP00000618938.1",
"transcript_support_level": null,
"aa_start": 956,
"aa_end": null,
"aa_length": 1143,
"cds_start": 2868,
"cds_end": null,
"cds_length": 3432,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948879.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2820A>C",
"hgvs_p": "p.Ser940Ser",
"transcript": "ENST00000948878.1",
"protein_id": "ENSP00000618937.1",
"transcript_support_level": null,
"aa_start": 940,
"aa_end": null,
"aa_length": 1127,
"cds_start": 2820,
"cds_end": null,
"cds_length": 3384,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948878.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 16,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2808A>C",
"hgvs_p": "p.Ser936Ser",
"transcript": "ENST00000912215.1",
"protein_id": "ENSP00000582274.1",
"transcript_support_level": null,
"aa_start": 936,
"aa_end": null,
"aa_length": 1123,
"cds_start": 2808,
"cds_end": null,
"cds_length": 3372,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000912215.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 17,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2790A>C",
"hgvs_p": "p.Ser930Ser",
"transcript": "ENST00000867860.1",
"protein_id": "ENSP00000537919.1",
"transcript_support_level": null,
"aa_start": 930,
"aa_end": null,
"aa_length": 1117,
"cds_start": 2790,
"cds_end": null,
"cds_length": 3354,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000867860.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2748A>C",
"hgvs_p": "p.Ser916Ser",
"transcript": "ENST00000948884.1",
"protein_id": "ENSP00000618943.1",
"transcript_support_level": null,
"aa_start": 916,
"aa_end": null,
"aa_length": 1103,
"cds_start": 2748,
"cds_end": null,
"cds_length": 3312,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948884.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2736A>C",
"hgvs_p": "p.Ser912Ser",
"transcript": "ENST00000948875.1",
"protein_id": "ENSP00000618934.1",
"transcript_support_level": null,
"aa_start": 912,
"aa_end": null,
"aa_length": 1099,
"cds_start": 2736,
"cds_end": null,
"cds_length": 3300,
"cdna_start": null,
"cdna_end": null,
"cdna_length": null,
"mane_select": null,
"mane_plus": null,
"biotype": "protein_coding",
"feature": "ENST00000948875.1"
},
{
"aa_ref": "S",
"aa_alt": "S",
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"synonymous_variant"
],
"exon_rank": 18,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": null,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.2736A>C",
"hgvs_p": "p.Ser912Ser",
"transcript": "ENST00000948886.1",
"protein_id": "ENSP00000618945.1",
"transcript_support_level": null,
"aa_start": 912,
"aa_end": null,
"aa_length": 1099,
"cds_start": 2736,
"cds_end": null,
"cds_length": 3300,
"cdna_start": null,
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}