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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-24897217-C-T (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=24897217&ref=C&alt=T&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 24897217,
"ref": "C",
"alt": "T",
"effect": "intron_variant",
"transcript": "ENST00000679454.1",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.675+21096G>A",
"hgvs_p": null,
"transcript": "NM_004036.5",
"protein_id": "NP_004027.2",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1144,
"cds_start": -4,
"cds_end": null,
"cds_length": 3435,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4950,
"mane_select": "ENST00000679454.1",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.675+21096G>A",
"hgvs_p": null,
"transcript": "ENST00000679454.1",
"protein_id": "ENSP00000505261.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1144,
"cds_start": -4,
"cds_end": null,
"cds_length": 3435,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4950,
"mane_select": "NM_004036.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.675+21096G>A",
"hgvs_p": null,
"transcript": "ENST00000405392.6",
"protein_id": "ENSP00000384484.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1145,
"cds_start": -4,
"cds_end": null,
"cds_length": 3438,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4182,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 1,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.675+21096G>A",
"hgvs_p": null,
"transcript": "ENST00000260600.9",
"protein_id": "ENSP00000260600.5",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 1144,
"cds_start": -4,
"cds_end": null,
"cds_length": 3435,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5050,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 23,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.675+21096G>A",
"hgvs_p": null,
"transcript": "NM_001377128.1",
"protein_id": "NP_001364057.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1166,
"cds_start": -4,
"cds_end": null,
"cds_length": 3501,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 5016,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.675+21096G>A",
"hgvs_p": null,
"transcript": "NM_001320613.2",
"protein_id": "NP_001307542.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1145,
"cds_start": -4,
"cds_end": null,
"cds_length": 3438,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4953,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.675+21096G>A",
"hgvs_p": null,
"transcript": "NM_001377132.1",
"protein_id": "NP_001364061.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1144,
"cds_start": -4,
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"cds_length": 3435,
"cdna_start": null,
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"cdna_length": 4507,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 22,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.675+21096G>A",
"hgvs_p": null,
"transcript": "NM_001377129.1",
"protein_id": "NP_001364058.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 1098,
"cds_start": -4,
"cds_end": null,
"cds_length": 3297,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4812,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.675+21096G>A",
"hgvs_p": null,
"transcript": "NM_001377130.1",
"protein_id": "NP_001364059.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 924,
"cds_start": -4,
"cds_end": null,
"cds_length": 2775,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 4466,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 8,
"intron_rank": 2,
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"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.675+21096G>A",
"hgvs_p": null,
"transcript": "ENST00000435135.5",
"protein_id": "ENSP00000389799.1",
"transcript_support_level": 5,
"aa_start": null,
"aa_end": null,
"aa_length": 481,
"cds_start": -4,
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"cdna_start": null,
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"mane_select": null,
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"feature": null
},
{
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"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 23,
"intron_rank": 2,
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"gene_symbol": "ADCY3",
"gene_hgnc_id": 234,
"hgvs_c": "c.675+21096G>A",
"hgvs_p": null,
"transcript": "XM_011532489.2",
"protein_id": "XP_011530791.1",
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},
{
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"consequences": [
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],
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},
{
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"consequences": [
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],
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"transcript": "XM_006711925.2",
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},
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],
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"gene_symbol": "ADCY3",
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],
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},
{
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],
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"intron_rank": 2,
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"gene_symbol": "ADCY3",
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},
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"strand": false,
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],
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"intron_rank": 2,
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"gene_symbol": "ADCY3",
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"hgvs_c": "c.675+21096G>A",
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"transcript": "XM_047443005.1",
"protein_id": "XP_047298961.1",
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},
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],
"exon_rank": null,
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"intron_rank": 2,
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},
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],
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},
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],
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"intron_rank": 2,
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"gene_symbol": "ADCY3",
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"hgvs_c": "c.675+21096G>A",
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"transcript": "XM_047443007.1",
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},
{
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"protein_coding": true,
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"consequences": [
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],
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"exon_count": 23,
"intron_rank": 2,
"intron_rank_end": null,
"gene_symbol": "ADCY3",
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"hgvs_c": "c.675+21096G>A",
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"transcript": "XM_011532494.2",
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}