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GeneBe API Showcase
This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.
API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.
Documentation & Advanced Usage
• Complete API documentation:docs.genebe.net/docs/api/overview/
• Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/
• Python client for pandas:pypi.org/project/genebe/
• Java CLI for VCF files:github.com/pstawinski/genebe-cli
• All tools documented at:docs.genebe.net
API Request Examples for Variant: 2-25432577-T-G (hg38)
Bash / cURL Example
bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=25432577&ref=T&alt=G&genome=hg38&allGenes=true"API Response
json
{
"variants": [
{
"chr": "2",
"pos": 25432577,
"ref": "T",
"alt": "G",
"effect": "intron_variant",
"transcript": "ENST00000406818.8",
"consequences": [
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "DTNB",
"gene_hgnc_id": 3058,
"hgvs_c": "c.1457+309A>C",
"hgvs_p": null,
"transcript": "NM_021907.5",
"protein_id": "NP_068707.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 627,
"cds_start": -4,
"cds_end": null,
"cds_length": 1884,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2417,
"mane_select": "ENST00000406818.8",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": true,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 21,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "DTNB",
"gene_hgnc_id": 3058,
"hgvs_c": "c.1457+309A>C",
"hgvs_p": null,
"transcript": "ENST00000406818.8",
"protein_id": "ENSP00000384084.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 627,
"cds_start": -4,
"cds_end": null,
"cds_length": 1884,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2417,
"mane_select": "NM_021907.5",
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "DTNB",
"gene_hgnc_id": 3058,
"hgvs_c": "c.1457+309A>C",
"hgvs_p": null,
"transcript": "ENST00000407661.7",
"protein_id": "ENSP00000385193.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 609,
"cds_start": -4,
"cds_end": null,
"cds_length": 1830,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2420,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "DTNB",
"gene_hgnc_id": 3058,
"hgvs_c": "c.1367+309A>C",
"hgvs_p": null,
"transcript": "ENST00000407038.7",
"protein_id": "ENSP00000384767.3",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 567,
"cds_start": -4,
"cds_end": null,
"cds_length": 1704,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2294,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "DTNB",
"gene_hgnc_id": 3058,
"hgvs_c": "c.1367+309A>C",
"hgvs_p": null,
"transcript": "ENST00000405222.5",
"protein_id": "ENSP00000384787.1",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": 560,
"cds_start": -4,
"cds_end": null,
"cds_length": 1683,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2273,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": false,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 18,
"intron_rank": 13,
"intron_rank_end": null,
"gene_symbol": "DTNB",
"gene_hgnc_id": 3058,
"hgvs_c": "n.*852+309A>C",
"hgvs_p": null,
"transcript": "ENST00000398951.6",
"protein_id": "ENSP00000381924.2",
"transcript_support_level": 1,
"aa_start": null,
"aa_end": null,
"aa_length": null,
"cds_start": -4,
"cds_end": null,
"cds_length": null,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2160,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 19,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "DTNB",
"gene_hgnc_id": 3058,
"hgvs_c": "c.1457+309A>C",
"hgvs_p": null,
"transcript": "NM_001320936.2",
"protein_id": "NP_001307865.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 625,
"cds_start": -4,
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"cds_length": 1878,
"cdna_start": null,
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"cdna_length": 2808,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "DTNB",
"gene_hgnc_id": 3058,
"hgvs_c": "c.1457+309A>C",
"hgvs_p": null,
"transcript": "NM_001256303.2",
"protein_id": "NP_001243232.1",
"transcript_support_level": null,
"aa_start": null,
"aa_end": null,
"aa_length": 620,
"cds_start": -4,
"cds_end": null,
"cds_length": 1863,
"cdna_start": null,
"cdna_end": null,
"cdna_length": 2396,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
"aa_ref": null,
"aa_alt": null,
"canonical": false,
"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
"exon_rank_end": null,
"exon_count": 20,
"intron_rank": 14,
"intron_rank_end": null,
"gene_symbol": "DTNB",
"gene_hgnc_id": 3058,
"hgvs_c": "c.1457+309A>C",
"hgvs_p": null,
"transcript": "ENST00000288642.12",
"protein_id": "ENSP00000288642.9",
"transcript_support_level": 2,
"aa_start": null,
"aa_end": null,
"aa_length": 620,
"cds_start": -4,
"cds_end": null,
"cds_length": 1863,
"cdna_start": null,
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"cdna_length": 2464,
"mane_select": null,
"mane_plus": null,
"biotype": null,
"feature": null
},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 18,
"intron_rank": 14,
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"gene_symbol": "DTNB",
"gene_hgnc_id": 3058,
"hgvs_c": "c.1457+309A>C",
"hgvs_p": null,
"transcript": "NM_001351394.2",
"protein_id": "NP_001338323.1",
"transcript_support_level": null,
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"cds_start": -4,
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"mane_select": null,
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},
{
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"protein_coding": true,
"strand": false,
"consequences": [
"intron_variant"
],
"exon_rank": null,
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"exon_count": 20,
"intron_rank": 14,
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"gene_symbol": "DTNB",
"gene_hgnc_id": 3058,
"hgvs_c": "c.1457+309A>C",
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"transcript": "NM_183360.3",
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{
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],
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},
{
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],
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"gene_symbol": "DTNB",
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"hgvs_c": "c.1367+309A>C",
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},
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],
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"gene_symbol": "DTNB",
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"transcript": "NM_033147.4",
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],
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},
{
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],
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"gene_symbol": "DTNB",
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},
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],
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"transcript": "NM_001351391.2",
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],
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"gene_symbol": "DTNB",
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"hgvs_c": "c.1367+309A>C",
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],
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"transcript": "NM_001351385.2",
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},
{
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"consequences": [
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],
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"intron_rank": 13,
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"gene_symbol": "DTNB",
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}
],
"message": null
}