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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-27025682-C-T (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=27025682&ref=C&alt=T&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "2",
      "pos": 27025682,
      "ref": "C",
      "alt": "T",
      "effect": "missense_variant",
      "transcript": "NM_012326.4",
      "consequences": [
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.569C>T",
          "hgvs_p": "p.Ser190Leu",
          "transcript": "NM_012326.4",
          "protein_id": "NP_036458.2",
          "transcript_support_level": null,
          "aa_start": 190,
          "aa_end": null,
          "aa_length": 281,
          "cds_start": 569,
          "cds_end": null,
          "cds_length": 846,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "ENST00000233121.7",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_012326.4"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": true,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.569C>T",
          "hgvs_p": "p.Ser190Leu",
          "transcript": "ENST00000233121.7",
          "protein_id": "ENSP00000233121.2",
          "transcript_support_level": 1,
          "aa_start": 190,
          "aa_end": null,
          "aa_length": 281,
          "cds_start": 569,
          "cds_end": null,
          "cds_length": 846,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": "NM_012326.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000233121.7"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.569C>T",
          "hgvs_p": "p.Ser190Leu",
          "transcript": "ENST00000879840.1",
          "protein_id": "ENSP00000549899.1",
          "transcript_support_level": null,
          "aa_start": 190,
          "aa_end": null,
          "aa_length": 282,
          "cds_start": 569,
          "cds_end": null,
          "cds_length": 849,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879840.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.569C>T",
          "hgvs_p": "p.Ser190Leu",
          "transcript": "NM_001303050.2",
          "protein_id": "NP_001289979.1",
          "transcript_support_level": null,
          "aa_start": 190,
          "aa_end": null,
          "aa_length": 281,
          "cds_start": 569,
          "cds_end": null,
          "cds_length": 846,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001303050.2"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.569C>T",
          "hgvs_p": "p.Ser190Leu",
          "transcript": "ENST00000879843.1",
          "protein_id": "ENSP00000549902.1",
          "transcript_support_level": null,
          "aa_start": 190,
          "aa_end": null,
          "aa_length": 281,
          "cds_start": 569,
          "cds_end": null,
          "cds_length": 846,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879843.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.569C>T",
          "hgvs_p": "p.Ser190Leu",
          "transcript": "ENST00000879845.1",
          "protein_id": "ENSP00000549904.1",
          "transcript_support_level": null,
          "aa_start": 190,
          "aa_end": null,
          "aa_length": 281,
          "cds_start": 569,
          "cds_end": null,
          "cds_length": 846,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879845.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.569C>T",
          "hgvs_p": "p.Ser190Leu",
          "transcript": "ENST00000969424.1",
          "protein_id": "ENSP00000639483.1",
          "transcript_support_level": null,
          "aa_start": 190,
          "aa_end": null,
          "aa_length": 281,
          "cds_start": 569,
          "cds_end": null,
          "cds_length": 846,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000969424.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.569C>T",
          "hgvs_p": "p.Ser190Leu",
          "transcript": "ENST00000969425.1",
          "protein_id": "ENSP00000639484.1",
          "transcript_support_level": null,
          "aa_start": 190,
          "aa_end": null,
          "aa_length": 281,
          "cds_start": 569,
          "cds_end": null,
          "cds_length": 846,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000969425.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.530C>T",
          "hgvs_p": "p.Ser177Leu",
          "transcript": "ENST00000969423.1",
          "protein_id": "ENSP00000639482.1",
          "transcript_support_level": null,
          "aa_start": 177,
          "aa_end": null,
          "aa_length": 269,
          "cds_start": 530,
          "cds_end": null,
          "cds_length": 810,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000969423.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.530C>T",
          "hgvs_p": "p.Ser177Leu",
          "transcript": "ENST00000879842.1",
          "protein_id": "ENSP00000549901.1",
          "transcript_support_level": null,
          "aa_start": 177,
          "aa_end": null,
          "aa_length": 268,
          "cds_start": 530,
          "cds_end": null,
          "cds_length": 807,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879842.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.524C>T",
          "hgvs_p": "p.Ser175Leu",
          "transcript": "ENST00000879838.1",
          "protein_id": "ENSP00000549897.1",
          "transcript_support_level": null,
          "aa_start": 175,
          "aa_end": null,
          "aa_length": 267,
          "cds_start": 524,
          "cds_end": null,
          "cds_length": 804,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879838.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.524C>T",
          "hgvs_p": "p.Ser175Leu",
          "transcript": "NM_001410716.1",
          "protein_id": "NP_001397645.1",
          "transcript_support_level": null,
          "aa_start": 175,
          "aa_end": null,
          "aa_length": 266,
          "cds_start": 524,
          "cds_end": null,
          "cds_length": 801,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_001410716.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.524C>T",
          "hgvs_p": "p.Ser175Leu",
          "transcript": "ENST00000402218.1",
          "protein_id": "ENSP00000385715.1",
          "transcript_support_level": 5,
          "aa_start": 175,
          "aa_end": null,
          "aa_length": 266,
          "cds_start": 524,
          "cds_end": null,
          "cds_length": 801,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000402218.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.524C>T",
          "hgvs_p": "p.Ser175Leu",
          "transcript": "ENST00000405074.7",
          "protein_id": "ENSP00000383915.3",
          "transcript_support_level": 3,
          "aa_start": 175,
          "aa_end": null,
          "aa_length": 266,
          "cds_start": 524,
          "cds_end": null,
          "cds_length": 801,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000405074.7"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 6,
          "exon_rank_end": null,
          "exon_count": 8,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.524C>T",
          "hgvs_p": "p.Ser175Leu",
          "transcript": "ENST00000648289.1",
          "protein_id": "ENSP00000497057.1",
          "transcript_support_level": null,
          "aa_start": 175,
          "aa_end": null,
          "aa_length": 266,
          "cds_start": 524,
          "cds_end": null,
          "cds_length": 801,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000648289.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.524C>T",
          "hgvs_p": "p.Ser175Leu",
          "transcript": "ENST00000879844.1",
          "protein_id": "ENSP00000549903.1",
          "transcript_support_level": null,
          "aa_start": 175,
          "aa_end": null,
          "aa_length": 266,
          "cds_start": 524,
          "cds_end": null,
          "cds_length": 801,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879844.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.524C>T",
          "hgvs_p": "p.Ser175Leu",
          "transcript": "ENST00000879846.1",
          "protein_id": "ENSP00000549905.1",
          "transcript_support_level": null,
          "aa_start": 175,
          "aa_end": null,
          "aa_length": 266,
          "cds_start": 524,
          "cds_end": null,
          "cds_length": 801,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 4,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.524C>T",
          "hgvs_p": "p.Ser175Leu",
          "transcript": "ENST00000879847.1",
          "protein_id": "ENSP00000549906.1",
          "transcript_support_level": null,
          "aa_start": 175,
          "aa_end": null,
          "aa_length": 266,
          "cds_start": 524,
          "cds_end": null,
          "cds_length": 801,
          "cdna_start": null,
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          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000879847.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
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          ],
          "exon_rank": 5,
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          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.524C>T",
          "hgvs_p": "p.Ser175Leu",
          "transcript": "ENST00000928331.1",
          "protein_id": "ENSP00000598390.1",
          "transcript_support_level": null,
          "aa_start": 175,
          "aa_end": null,
          "aa_length": 266,
          "cds_start": 524,
          "cds_end": null,
          "cds_length": 801,
          "cdna_start": null,
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          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000928331.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.485C>T",
          "hgvs_p": "p.Ser162Leu",
          "transcript": "ENST00000879841.1",
          "protein_id": "ENSP00000549900.1",
          "transcript_support_level": null,
          "aa_start": 162,
          "aa_end": null,
          "aa_length": 253,
          "cds_start": 485,
          "cds_end": null,
          "cds_length": 762,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879841.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.470C>T",
          "hgvs_p": "p.Ser157Leu",
          "transcript": "ENST00000879839.1",
          "protein_id": "ENSP00000549898.1",
          "transcript_support_level": null,
          "aa_start": 157,
          "aa_end": null,
          "aa_length": 248,
          "cds_start": 470,
          "cds_end": null,
          "cds_length": 747,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000879839.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.443C>T",
          "hgvs_p": "p.Ser148Leu",
          "transcript": "ENST00000969422.1",
          "protein_id": "ENSP00000639481.1",
          "transcript_support_level": null,
          "aa_start": 148,
          "aa_end": null,
          "aa_length": 239,
          "cds_start": 443,
          "cds_end": null,
          "cds_length": 720,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000969422.1"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 6,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.569C>T",
          "hgvs_p": "p.Ser190Leu",
          "transcript": "ENST00000458529.5",
          "protein_id": "ENSP00000391705.1",
          "transcript_support_level": 5,
          "aa_start": 190,
          "aa_end": null,
          "aa_length": 217,
          "cds_start": 569,
          "cds_end": null,
          "cds_length": 654,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000458529.5"
        },
        {
          "aa_ref": "S",
          "aa_alt": "L",
          "canonical": false,
          "protein_coding": true,
          "strand": true,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 5,
          "exon_rank_end": null,
          "exon_count": 7,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "MAPRE3",
          "gene_hgnc_id": 6892,
          "hgvs_c": "c.569C>T",
          "hgvs_p": "p.Ser190Leu",
          "transcript": "XM_047443728.1",
          "protein_id": "XP_047299684.1",
          "transcript_support_level": null,
          "aa_start": 190,
          "aa_end": null,
          "aa_length": 281,
          "cds_start": 569,
          "cds_end": null,
          "cds_length": 846,
          "cdna_start": null,
          "cdna_end": null,
          "cdna_length": null,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "XM_047443728.1"
        }
      ],
      "gene_symbol": "MAPRE3",
      "gene_hgnc_id": 6892,
      "dbsnp": "rs1043008915",
      "frequency_reference_population": 0.000026274649,
      "hom_count_reference_population": 0,
      "allele_count_reference_population": 4,
      "gnomad_exomes_af": null,
      "gnomad_genomes_af": 0.0000262746,
      "gnomad_exomes_ac": null,
      "gnomad_genomes_ac": 4,
      "gnomad_exomes_homalt": null,
      "gnomad_genomes_homalt": 0,
      "gnomad_mito_homoplasmic": null,
      "gnomad_mito_heteroplasmic": null,
      "computational_score_selected": 0.12352663278579712,
      "computational_prediction_selected": "Benign",
      "computational_source_selected": "MetaRNN",
      "splice_score_selected": 0,
      "splice_prediction_selected": "Benign",
      "splice_source_selected": "max_spliceai",
      "revel_score": 0.042,
      "revel_prediction": "Benign",
      "alphamissense_score": 0.063,
      "alphamissense_prediction": null,
      "bayesdelnoaf_score": -0.6,
      "bayesdelnoaf_prediction": "Benign",
      "phylop100way_score": 3.227,
      "phylop100way_prediction": "Benign",
      "spliceai_max_score": 0,
      "spliceai_max_prediction": "Benign",
      "dbscsnv_ada_score": null,
      "dbscsnv_ada_prediction": null,
      "apogee2_score": null,
      "apogee2_prediction": null,
      "mitotip_score": null,
      "mitotip_prediction": null,
      "acmg_score": 0,
      "acmg_classification": "Uncertain_significance",
      "acmg_criteria": "PM2,BP4_Moderate",
      "acmg_by_gene": [
        {
          "score": 0,
          "benign_score": 2,
          "pathogenic_score": 2,
          "criteria": [
            "PM2",
            "BP4_Moderate"
          ],
          "verdict": "Uncertain_significance",
          "transcript": "NM_012326.4",
          "gene_symbol": "MAPRE3",
          "hgnc_id": 6892,
          "effects": [
            "missense_variant"
          ],
          "inheritance_mode": "AD",
          "hgvs_c": "c.569C>T",
          "hgvs_p": "p.Ser190Leu"
        }
      ],
      "clinvar_disease": "not specified",
      "clinvar_classification": "Uncertain significance",
      "clinvar_review_status": "criteria provided, single submitter",
      "clinvar_submissions_summary": "US:1",
      "phenotype_combined": "not specified",
      "pathogenicity_classification_combined": "Uncertain significance",
      "custom_annotations": null
    }
  ],
  "message": null
}