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GeneBe API Showcase

This page demonstrates how to use the GeneBe API to query variant information. The API provides programmatic access to genomic annotations and variant data.

API presented here should be used for checking single variants. If you want to check many variants at once, please use other API endpoints that you will find in the documentation.

Documentation & Advanced Usage

Complete API documentation:docs.genebe.net/docs/api/overview/

Interactive endpoint tester:api.genebe.net/cloud/gb-api-doc/swagger-ui/

Python client for pandas:pypi.org/project/genebe/

Java CLI for VCF files:github.com/pstawinski/genebe-cli

All tools documented at:docs.genebe.net

API Request Examples for Variant: 2-27201024-G-A (hg38)

Bash / cURL Example

bash
curl "https://api.genebe.net/cloud/api-public/v1/variant?chr=2&pos=27201024&ref=G&alt=A&genome=hg38&allGenes=true"

API Response

json
{
  "variants": [
    {
      "chr": "2",
      "pos": 27201024,
      "ref": "G",
      "alt": "A",
      "effect": "missense_variant",
      "transcript": "NM_021095.4",
      "consequences": [
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC5A6",
          "gene_hgnc_id": 11041,
          "hgvs_c": "c.1738C>T",
          "hgvs_p": "p.Arg580Trp",
          "transcript": "NM_021095.4",
          "protein_id": "NP_066918.2",
          "transcript_support_level": null,
          "aa_start": 580,
          "aa_end": null,
          "aa_length": 635,
          "cds_start": 1738,
          "cds_end": null,
          "cds_length": 1908,
          "cdna_start": 2194,
          "cdna_end": null,
          "cdna_length": 3213,
          "mane_select": "ENST00000310574.8",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "NM_021095.4"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": true,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC5A6",
          "gene_hgnc_id": 11041,
          "hgvs_c": "c.1738C>T",
          "hgvs_p": "p.Arg580Trp",
          "transcript": "ENST00000310574.8",
          "protein_id": "ENSP00000310208.3",
          "transcript_support_level": 1,
          "aa_start": 580,
          "aa_end": null,
          "aa_length": 635,
          "cds_start": 1738,
          "cds_end": null,
          "cds_length": 1908,
          "cdna_start": 2194,
          "cdna_end": null,
          "cdna_length": 3213,
          "mane_select": "NM_021095.4",
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000310574.8"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC5A6",
          "gene_hgnc_id": 11041,
          "hgvs_c": "c.1738C>T",
          "hgvs_p": "p.Arg580Trp",
          "transcript": "ENST00000408041.5",
          "protein_id": "ENSP00000384853.1",
          "transcript_support_level": 1,
          "aa_start": 580,
          "aa_end": null,
          "aa_length": 635,
          "cds_start": 1738,
          "cds_end": null,
          "cds_length": 1908,
          "cdna_start": 2060,
          "cdna_end": null,
          "cdna_length": 2230,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000408041.5"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC5A6",
          "gene_hgnc_id": 11041,
          "hgvs_c": "c.1771C>T",
          "hgvs_p": "p.Arg591Trp",
          "transcript": "ENST00000892752.1",
          "protein_id": "ENSP00000562811.1",
          "transcript_support_level": null,
          "aa_start": 591,
          "aa_end": null,
          "aa_length": 646,
          "cds_start": 1771,
          "cds_end": null,
          "cds_length": 1941,
          "cdna_start": 2222,
          "cdna_end": null,
          "cdna_length": 3241,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000892752.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC5A6",
          "gene_hgnc_id": 11041,
          "hgvs_c": "c.1738C>T",
          "hgvs_p": "p.Arg580Trp",
          "transcript": "ENST00000892748.1",
          "protein_id": "ENSP00000562807.1",
          "transcript_support_level": null,
          "aa_start": 580,
          "aa_end": null,
          "aa_length": 635,
          "cds_start": 1738,
          "cds_end": null,
          "cds_length": 1908,
          "cdna_start": 2130,
          "cdna_end": null,
          "cdna_length": 3149,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000892748.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC5A6",
          "gene_hgnc_id": 11041,
          "hgvs_c": "c.1738C>T",
          "hgvs_p": "p.Arg580Trp",
          "transcript": "ENST00000892751.1",
          "protein_id": "ENSP00000562810.1",
          "transcript_support_level": null,
          "aa_start": 580,
          "aa_end": null,
          "aa_length": 635,
          "cds_start": 1738,
          "cds_end": null,
          "cds_length": 1908,
          "cdna_start": 2262,
          "cdna_end": null,
          "cdna_length": 3281,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000892751.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC5A6",
          "gene_hgnc_id": 11041,
          "hgvs_c": "c.1738C>T",
          "hgvs_p": "p.Arg580Trp",
          "transcript": "ENST00000892753.1",
          "protein_id": "ENSP00000562812.1",
          "transcript_support_level": null,
          "aa_start": 580,
          "aa_end": null,
          "aa_length": 635,
          "cds_start": 1738,
          "cds_end": null,
          "cds_length": 1908,
          "cdna_start": 2147,
          "cdna_end": null,
          "cdna_length": 3163,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000892753.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC5A6",
          "gene_hgnc_id": 11041,
          "hgvs_c": "c.1738C>T",
          "hgvs_p": "p.Arg580Trp",
          "transcript": "ENST00000892754.1",
          "protein_id": "ENSP00000562813.1",
          "transcript_support_level": null,
          "aa_start": 580,
          "aa_end": null,
          "aa_length": 635,
          "cds_start": 1738,
          "cds_end": null,
          "cds_length": 1908,
          "cdna_start": 2019,
          "cdna_end": null,
          "cdna_length": 3033,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000892754.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC5A6",
          "gene_hgnc_id": 11041,
          "hgvs_c": "c.1738C>T",
          "hgvs_p": "p.Arg580Trp",
          "transcript": "ENST00000892755.1",
          "protein_id": "ENSP00000562814.1",
          "transcript_support_level": null,
          "aa_start": 580,
          "aa_end": null,
          "aa_length": 635,
          "cds_start": 1738,
          "cds_end": null,
          "cds_length": 1908,
          "cdna_start": 2064,
          "cdna_end": null,
          "cdna_length": 3083,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000892755.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC5A6",
          "gene_hgnc_id": 11041,
          "hgvs_c": "c.1738C>T",
          "hgvs_p": "p.Arg580Trp",
          "transcript": "ENST00000892756.1",
          "protein_id": "ENSP00000562815.1",
          "transcript_support_level": null,
          "aa_start": 580,
          "aa_end": null,
          "aa_length": 635,
          "cds_start": 1738,
          "cds_end": null,
          "cds_length": 1908,
          "cdna_start": 2045,
          "cdna_end": null,
          "cdna_length": 3064,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000892756.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 14,
          "exon_rank_end": null,
          "exon_count": 15,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC5A6",
          "gene_hgnc_id": 11041,
          "hgvs_c": "c.1738C>T",
          "hgvs_p": "p.Arg580Trp",
          "transcript": "ENST00000892757.1",
          "protein_id": "ENSP00000562816.1",
          "transcript_support_level": null,
          "aa_start": 580,
          "aa_end": null,
          "aa_length": 635,
          "cds_start": 1738,
          "cds_end": null,
          "cds_length": 1908,
          "cdna_start": 2401,
          "cdna_end": null,
          "cdna_length": 3417,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000892757.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
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          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC5A6",
          "gene_hgnc_id": 11041,
          "hgvs_c": "c.1738C>T",
          "hgvs_p": "p.Arg580Trp",
          "transcript": "ENST00000926531.1",
          "protein_id": "ENSP00000596590.1",
          "transcript_support_level": null,
          "aa_start": 580,
          "aa_end": null,
          "aa_length": 635,
          "cds_start": 1738,
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          "cdna_start": 2009,
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          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "R",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC5A6",
          "gene_hgnc_id": 11041,
          "hgvs_c": "c.1738C>T",
          "hgvs_p": "p.Arg580Trp",
          "transcript": "ENST00000926534.1",
          "protein_id": "ENSP00000596593.1",
          "transcript_support_level": null,
          "aa_start": 580,
          "aa_end": null,
          "aa_length": 635,
          "cds_start": 1738,
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          "cdna_start": 2166,
          "cdna_end": null,
          "cdna_length": 3185,
          "mane_select": null,
          "mane_plus": null,
          "biotype": "protein_coding",
          "feature": "ENST00000926534.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 15,
          "exon_rank_end": null,
          "exon_count": 16,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC5A6",
          "gene_hgnc_id": 11041,
          "hgvs_c": "c.1738C>T",
          "hgvs_p": "p.Arg580Trp",
          "transcript": "ENST00000926537.1",
          "protein_id": "ENSP00000596596.1",
          "transcript_support_level": null,
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          "mane_select": null,
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        },
        {
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          "consequences": [
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          ],
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          "intron_rank": null,
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          "gene_symbol": "SLC5A6",
          "gene_hgnc_id": 11041,
          "hgvs_c": "c.1738C>T",
          "hgvs_p": "p.Arg580Trp",
          "transcript": "ENST00000962472.1",
          "protein_id": "ENSP00000632531.1",
          "transcript_support_level": null,
          "aa_start": 580,
          "aa_end": null,
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          "cds_start": 1738,
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          "cds_length": 1908,
          "cdna_start": 2398,
          "cdna_end": null,
          "cdna_length": 3415,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000962472.1"
        },
        {
          "aa_ref": "R",
          "aa_alt": "W",
          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
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          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
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          "gene_symbol": "SLC5A6",
          "gene_hgnc_id": 11041,
          "hgvs_c": "c.1738C>T",
          "hgvs_p": "p.Arg580Trp",
          "transcript": "ENST00000962473.1",
          "protein_id": "ENSP00000632532.1",
          "transcript_support_level": null,
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          "cdna_start": 2180,
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          "cdna_length": 3195,
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          "biotype": "protein_coding",
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        },
        {
          "aa_ref": "R",
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          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 17,
          "exon_rank_end": null,
          "exon_count": 18,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC5A6",
          "gene_hgnc_id": 11041,
          "hgvs_c": "c.1738C>T",
          "hgvs_p": "p.Arg580Trp",
          "transcript": "ENST00000962474.1",
          "protein_id": "ENSP00000632533.1",
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        {
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          "exon_count": 18,
          "intron_rank": null,
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          "gene_symbol": "SLC5A6",
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          "hgvs_c": "c.1738C>T",
          "hgvs_p": "p.Arg580Trp",
          "transcript": "ENST00000962475.1",
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          "mane_select": null,
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          "biotype": "protein_coding",
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        },
        {
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          "intron_rank": null,
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          "gene_symbol": "SLC5A6",
          "gene_hgnc_id": 11041,
          "hgvs_c": "c.1735C>T",
          "hgvs_p": "p.Arg579Trp",
          "transcript": "ENST00000926529.1",
          "protein_id": "ENSP00000596588.1",
          "transcript_support_level": null,
          "aa_start": 579,
          "aa_end": null,
          "aa_length": 634,
          "cds_start": 1735,
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          "cds_length": 1905,
          "cdna_start": 2187,
          "cdna_end": null,
          "cdna_length": 3206,
          "mane_select": null,
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          "biotype": "protein_coding",
          "feature": "ENST00000926529.1"
        },
        {
          "aa_ref": "R",
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          "canonical": false,
          "protein_coding": true,
          "strand": false,
          "consequences": [
            "missense_variant"
          ],
          "exon_rank": 16,
          "exon_rank_end": null,
          "exon_count": 17,
          "intron_rank": null,
          "intron_rank_end": null,
          "gene_symbol": "SLC5A6",
          "gene_hgnc_id": 11041,
          "hgvs_c": "c.1648C>T",
          "hgvs_p": "p.Arg550Trp",
          "transcript": "ENST00000892750.1",
          "protein_id": "ENSP00000562809.1",
          "transcript_support_level": null,
          "aa_start": 550,
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}
For research and educational, non-commercial use only. Not for clinical or diagnostic use. GeneBe does not provide medical advice. Data use for AI modeling is prohibited: if used, the cost is $0.001 per byte of downloaded uncompressed data.